دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Deregulated signalling networks in human brain tumours

Keywords: GBM; glioblastoma multiforme; RTK; receptor tyrosine kinase; EGF(R); epidermal growth factor (receptor); PDGF(R); platelet-derived growth factor (receptor); VEGF(R); vascular endothelial growth factor (receptor); ERBB2; v-erb-b2 erythroblastic leukemia vi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences

Keywords: PH; Pleckstrin Homology; PI3K; Phosphatidyl 3OH Kinase; PtdIns(3,4,5)P3; Phosphatidylinositol-(3,4,5)-trisphosphate; PtdIns(3,4)P2; Phosphatidylinositol-(3,4)-bisphosphate; GAP; GTPase Activating Protein; SAM; Sterile Alpha Motif; SHIP2; SH2-containing in

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons

Keywords: Olfactory signal transduction; Phosphoinositides; PLC; PI3K; ORNs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Somatic mutations in PI3Kα: Structural basis for enzyme activation and drug design

Keywords: PI3K; p110/p85; Somatic mutation; Gain of function; H1047R mutant;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium

Keywords: MSCs; mesenchymal stem cells; PI3K; phosphoinositide-3-kinase; PIK3-C2α; phosphoinositide-3-kinase class 2 alpha; Cardiac regeneration; Lentivirus; Mesenchymal stem cells; Phosphoinositide-3-kinase class II alpha; Survival;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: Effect on myotube fusion

Keywords: Myoblast; PI3K; Akt; MAPK; Fusion; Muscular dystrophies

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Transcriptional regulation of the insulin signaling pathway genes by starvation and 20-hydroxyecdysone in the Bombyx fat body

Keywords: InR; IRS; PI3K; PTEN; PDK; Akt; Transcriptional regulation; Starvation; 20-Hydroxyecdysone; Fat body; Bombyx mori

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of transition metals in synaptic damage induced by amyloid beta peptide

Keywords: iron; copper; synaptosomes; Akt; ERK1/2; Aβ peptide; AD; Alzheimer's disease; ADDLs; amyloid-beta derived diffusible ligands; Aβ; amyloid-beta peptide; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EM; electron microscopy; ERK1/2; ext

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

NGF-induced moesin phosphorylation is mediated by the PI3K, Rac1 and Akt and required for neurite formation in PC12 cells

Keywords: Moesin; NGF; Akt; PI3K; Rac1; Neurite outgrowth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Liver cancer: From molecular pathogenesis to new therapies

Keywords: DEB; drug-eluting bead; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; hTERT; human telomerase reverse transcriptase; PDGF; platelet derived growth factor; FAK; focal adhesion kinase; Pyk2; proline-rich tyrosine kinase 2; M

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity

Keywords: Parkinson's disease; GDNF; Dopaminergic neurons; Microglia; Nitric oxide; PI3K

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticlePhosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

Keywords: CPT-2-Me-cAMP; 4-(4-chloro-phenylthio)-2'-O-methyladenosine-3′-5′-cyclic monophosphate; JNK; c-Jun N-terminal kinase; GCDC; glycochenodeoxycholate; GPCR; G protein-coupled receptors; PtIns; phosphatidylinositides; PI3K; phosphatidylinositol 3-kinase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance

Keywords: PLC; phospholipase C; PI(4,5)P2; phosphatidylinositol 4,5-bisphosphate; PI(3,4,5)P2; phosphatidylinositol 3,4,5-bisphosphate; Ins(1,4,5)P3; inositol 1,4,5-trisphosphate; DAG; diacylglycerol; PKC; protein kinase C; PI3K; phosphatidylinositol 3-kinase; PDGF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways

Keywords: ChIP; chromatin immunoprecipitation; CYP; cytochrome P450; Elk1; member of ETS oncogene family; FOXO1; forkhead box protein O1; IL-4; interleukin-4; IL-4R; interleukin-4 receptor; IRS; insulin receptor substrate; JAK; janus protein kinase; MAPK; mitogen-a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis

Keywords: AEBP1; AE-binding protein 1; C/EBP; CCAAT/enhancer-binding protein; CS; citrate synthase; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FABP4; fatty acid-binding protein 4; FBS; foetal bovi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats

Keywords: MIF; macrophage migration inhibitory factor; NMDAR; NMDA receptor; CSF; cerebrospinal fluid; rMIF; recombinant rat MIF; MAPK; mitogen-activated protein kinase; p-p38 MAPK; phosphorylated p38 MAPK; ERK; extracellular signal regulated kinase; PI3K; phosphoi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Neuroprotective effects of (−)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition

Keywords: Apoptosis; EGCG; GSK-3β; Nitric oxide; PI3K; Quinolinic acid

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity

Keywords: βAR, β-adrenergic receptor; CaMKII, Ca(2+)/calmodulin-dependent protein kinase II; DM, diabetes mellitus; HF, heart failure; HW/T, heart weight-to-tibia length ratio; ISO, isoproterenol; LV, left ventricle; PDK-1, phosphoinositide dependent kinase 1; PI3K

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Osteopontin is required for unloading-induced osteoclast recruitment and modulation of RANKL expression during tooth drift-associated bone remodeling, but not for super-eruption

Keywords: Osteopontin; RANKL; PI3K; ERK; Bone remodeling; Mechanical stress

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of phosphatidylinositol-3-kinase/Akt and modulation of extracellular signal-regulated kinase 1/2 activation in PC12 cells and neurons

Keywords: chronic ethanol; mesenchymal stem cells conditioned medium; antioxidant action; signal transduction pathways; PC12 cells; primary cortical neurons; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; DMEM; Dulbecco's modified

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

α9β1 integrin engagement inhibits neutrophil spontaneous apoptosis: Involvement of Bcl-2 family members

Keywords: ADAM; a disintegrin and metalloprotease; ECM; extracellular matrix; Erk; extracellular signal-regulated kinase; FAK; focal adhesion kinase; JNK; c-Jun kinase; NF-κB; nuclear factor-κB; PI3K; phosphatidylinositol-3-kinase; PMN; polymorphonuclear leukocyt

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy

Keywords: PI3K; Phosphoinositide; PH domain; Confocal microscopy; Fluorescence; Colorectal cancer

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells

Keywords: Nestin; Neural progenitor cells; Proliferation; PI3K; siRNA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Lysophosphatidic acid induces upregulation of Mcl-1 and protects apoptosis in a PTX-dependent manner in H19-7 cells

Keywords: LPA; lysophosphatidic acid; NPC; neuronal progenitor cell; Mcl; myeloid cell leukemia; GSK-3; glycogen synthase kinase 3; PTX; pertussis toxin; FGF; fibroblast growth factor; S1P; sphingosine 1-phosphate; GPCR; G-protein coupled receptor; E; embryonic day

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

Keywords: Gal-1; galectin-1; TLR; TOLL-like receptors; LPS; endotoxin lipopolysaccharide; WT; wild-type; TS; T. cruzi trans-sialidase; TS∆Asp98-Glu; the catalytically inactive mutant TS; MAL-2; sialyl α-2,3-specific Maackia amurensis lectin; SNA; sialyl α-2,6-s

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells

Keywords: lipid rafts; haloperidol; antipsychotic drug; insulin; cholesterol biosynthesis; signal transduction; BCA; bicinchoninic acid; CtxB; cholera toxin B; DiI; 1,1′-dioctadecyl-3,3,3,3′-tetramethylindocarbocyanineperchlorate; FBS; fetal bovine serum; GC/MS

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells

Keywords: Akt; Cobra venom; Cardiotoxin; JAK2; MDA-MB-231 cells; PI3K; STAT3

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Hepatitis C Virus Regulates Transforming Growth Factor β1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor κB-Dependent Manner

Keywords: Hepatitis C Virus; Reactive Oxygen Species; Nuclear Factor κB; Transforming Growth Factor β1; AQ; 6-amino-4-(4-phenoxyphenylethylamino) quinazoline; DMSO; dimethyl sulfoxide; DPI; diphenyliodonium; ECL; electrochemiluminescence; ERK; extracellular signa

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Keywords: β1 integrin; PI3K; p110α; Cell spreading; Akt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K)

Keywords: Influenza A virus; Reverse genetics; NS1; Apoptosis; PI3K;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

Keywords: Lysophosphatidic acid; Transactivation; Brown adipocytes; Erk1/2; EGF receptor; PI3K

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Oncogenic KRAS Desensitizes Colorectal Tumor Cells to Epidermal Growth Factor Receptor Inhibition and Activation

Keywords: EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; MEK; MAPK/ERK kinase; PI3K; phosphatidylinositol-3-kinase;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model

Keywords: ErbB2; epidermal growth factor receptor B2; Erk2; extracellular signal-regulated kinase 2; HIF-a; hypoxia factor 1-α; iNOS; inducible nitric oxide sintetase; IL-; Interleukin; MAPKs; mitogen-activated protein kinases; MIP-2; macrophage inflammatory prote

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

3-Methyladenine blocks Toxoplasma gondii division prior to centrosome replication

Keywords: 3-MA; 3-methyladenine; GFP; green fluorescent protein; HFF; human foreskin fibroblasts; IMC; inner membrane complex; NST; nuclear sugar transporter; PI3K; phosphatidylinositol 3-kinase; PDTC; pyrrolidone dithiocarbamate; S+T-Red; S+TACP-HcRed; YFP; yellow

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation

Keywords: chronic pain; microglial memory; MAPK; opioids; paw incision; glia; ERK; extracellular receptor kinase; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium adaptor-binding protein 1; JNK; c-Jun N-terminal kinase; MAPK; mitogen activated protein k

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Differentiation of Pancreatic Acinar Cells to Hepatocytes Requires an Intermediate Cell Type

Keywords: Pancreas; Metaplasia; Transdifferentiation; Plasticity; ABCG2; ATP-binding cassette sub-family G member 2; AMY; amylase; bp; base pair; C/EBPβ; CCAAT enhancer binding protein β; CPA; carboxypeptidase A; CYP; cytochrome P450; CYP3A1; cytochrome p450 3A1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity

Keywords: 17 β-TBOH; trenbolone; 17 α-TBOH; epitrenbolone; 17β-E2; estradiol; AR; androgen receptor; Akt; serine/threonine-specific kinase family; ACTH; adrenocorticotropic hormone; BMD; bone mineral density; Ca2+; calcium; CSA; cross-sectional area; DHT; dihydr

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension

Keywords: DHEA; Pulmonary arterial hypertension; Smooth muscle cell; K+ channel; Mitochondria; PI3K; HIF-1 and NFAT[Ca2+i], intracellular free calcium concentration; CH, chronic hypoxia; DHEA, dehydroepiandrosterone; DHEA-S, dehydroepiandrosterone sulfate ester; IP

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

Keywords: APC; adenomatous polyposis coli gene; CAC; colitis-associated cancer; CRC; colorectal cancer; HD; high dose; LD; low dose; P-β-catenin; Akt-phosphorylated β-catenin; PI3K; phosphoinositide-3 kinase; PPARγ; peroxisome proliferator-activated receptor γ;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma

Keywords: AKT; v-akt murine thymoma viral oncogene homolog; ANOVA; analysis of variance; ATCC; American Type Culture Collection; BRAF; v-raf murine sarcoma viral oncogene homolog B1; BRAFm; BRAF mutation; CKIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Invasive Glioblastoma Cells Acquire Stemness and Increased Akt Activation

Keywords: GBM; glioblastoma multiforme; Erk; extracellular signal-regulated kinase; PI3K; phosphatidylinositol 3-OH kinase; ECM; extracellular matrix; GFP; green fluorescent protein; PHLPP; PH domain leucine-rich repeat protein phosphatase;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking

Keywords: EEA1; Early endosomal autoantigen 1; FRAP; Fluorescence recovery after photobleaching; GAP; GTPase activating protein; GDI; Guanine nucleotide dissociation inhibitor; GEF; Guanine nucleotide exchange factor; MAPK; Mitogen-activated protein kinase; p85α;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Angiogenesis and Current Antiangiogenic Strategies for the Treatment of Cancer

Keywords: bFGF; basic fibroblast growth factor; DLL4; Notch ligand delta-like 4; ERK; extracellular signal-regulated kinase; FDA; Food and Drug Administration; HIF; hypoxia-inducible factor; MAPK; mitogen-activated protein kinase; MMP; matrix metalloproteinase; m

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

Corticotropin-Releasing Hormone Family of Peptides Regulates Intestinal Angiogenesis

Keywords: Neuropeptide; Inflammatory Bowel Disease; PI3K; HIMECs; CRH; corticotropin-releasing hormone; CRHR; CRH receptor; DSS; dextran sodium sulfate; EC; endothelial cell; HIMECs; human intestinal microvascular endothelial cells; IBD; inflammatory bowel disease;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats

Keywords: mTOR; rapamycin; signal transduction pathway; locomotor functional recovery; spine; nervous system injury; Akt; protein kinase B; BBB; Basso-Beattie-Bresnahan; BSA; bovine serum albumin; CNS; central nervous system; DAB; 3,3-diaminobenzidine; GAPDH; g

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: Focus on Pi3K/AKT/eNOS pathway

Keywords: Endothelial progenitor cell; eNOS; Akt; Pi3K

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ

Keywords: Inflammatory Bowel Diseases; Innate Immunity; PI3-Kinase; Enteric Microbiota; BMM; bone marrow-derived macrophage; ELISA; enzyme-linked immunosorbent assay; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GF; germ-free; hpf; high-power field; IFN; inte

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

Keywords: Apoptosis; Brain-derived neurotrophic factor (BDNF); Glycogen synthase kinase 3 (GSK-3); Lithium; Neurodegenerative diseases; Neuroprotection; 3-NP; 3-nitropropionic acid; Aβ; β-amyloid; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AP-1;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2010 سفارش ترجمه

Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism

Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2010 سفارش ترجمه

Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR

Keywords: Mammalian target of rapamycin; mTOR; Kinase inhibitors; Phosphatidylinositol 3-kinase; PI3K

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه