دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Development of sulfonamide AKT PH domain inhibitors

Keywords: AKT; protein kinase B; β-ARK; β-adrenergic receptor kinase; CREB; cAMP response element-binding; DMEM; Dulbecco's modified Eagle medium; DPIEL; deoxyphosphatidylinositol ether lipid; ELISA; enzyme-linked immunosorbent assay; ESI; electrospray ionizati

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress, insulin signaling, and diabetes

Keywords: AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons

Keywords: CGNs; cerebellar granule neurons; S/K; serum potassium deprivation; CDK; cyclin-dependent kinase; JNK; c-Jun N-terminal kinase; GSK3β; glycogen synthase kinase 3β; PI3K; phosphatidylinositol-3 kinase; IGF-1; insulin-like growth factor-I; CDK5/p25; LY294

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

Keywords: Arrestins; GPCR; Signaling; Chemotaxis; MAPK; PI3K; PDE4; Ubiquitin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling

Keywords: ACTH; adrenocorticotropic hormone; cAMP; cyclic 3′,5′-adenosine monophosphate; AGRP; agouti-related protein; CTX; cholera toxin; ER; endoplasmic reticulum; ERK-1/2; extracellular signal-regulated kinases; FSK; forskolin; GPCR; G protein-coupled recept

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export

Keywords: CAT; chloramphenicol acetyltransferase; CPE; cytopathic effect; KKT; Ko-Ken Tang; pfu; plaque forming unit; PI3K; phosphatidylinositol 3-kinase; moi; multiplicity of infection; pi; post viral infection; RdRp; RNA-dependent RNA polymerase; RNP; ribonucleop

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Tumor necrosis factor-α increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes

Keywords: TNF-α; tumor necrosis factor-α; IRE; insulin response element; FBE; Fox binging element; Foxo1; forkhead box o1; C/EBP; CCAAT/enhancer binding protein; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; RACE; rapid amplification of cDNA ends; shRNA; short

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Several agents and pathways regulate lipolysis in adipocytes

Keywords: Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Moving to tolerance: Clinical application of T regulatory cells

Keywords: APC; antigen presenting cell; ATG; anti thymocyte globulin; aTreg; adaptive T regulatory cell; AZT; 3′-azido-3′-deoxythymidine; CNI; calcineurin inhibitor; CyA; cyclosporin A; DC; dendiric cell; DST; donor specific transfusion; GVHD; graft versus host

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleGlycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis

Keywords: Cirrhosis; Alcohol; Innate immunity; Lipopolysaccharides; AKT; Glycogen synthase kinase 3; TLR4; Toll-like receptor 4; LPS; lipopolysaccharides; TNF-α; tumor necrosis factor-α; IL; interleukin; GSK3; glycogen synthase kinase 3; PI3K; phosphatidylinosito

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans

Keywords: Pa-EE; ethanol extract of Phaseolus angularis; LPS; lipopolysaccharide; NO; nitric oxide; PG; prostaglandin; iNOS; inducible NO synthase; COX; cyclooxy-genase; IL; interleukin; IKK; I (B) kinase; Akt; protein kinase B; PDK; phosphoinositide-dependent kina

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers

Keywords: Cdc42; cell division cycle 42; GEF; Guanine nucleotide exchange factor; GPCR; G-protein coupled receptor; LFA-1; Leukocyte function-associated antigen-1; LTB4; leukotriene B4; PAF; platelet activating factor; PI3K; Phosphatidylinositol 3-kinase; PIP2; pho

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the development and treatment of uterine cancer

Keywords: Endometrial cancer; Uterine cancer; PI3K; mTOR; PTEN; AKT

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

TH17 cytokines induce human airway smooth muscle cell migration

Keywords: Asthma; airway remodeling; TH17; airway smooth muscle cells; migration; ASM; Airway smooth muscle; ASMC; Airway smooth muscle cell; IκBα; Nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, α; MAPK; Mitogen-activated protein kina

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways

Keywords: Alternate-day fasting; Heart; Hypertrophy; PI3K; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart

Keywords: AC; adenylyl cyclase; ATP; adenosine triphosphate; βAR; β-adrenergic receptor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; DNA; deoxyribonucleic acid; DTT; dithiothreitol; ET-1; endothelin 1; ERK; extracellular signal-regulated kinase; GPCR; G

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway

Keywords: ADAM; a disintegrin and metalloproteinase; BSA; bovine serum albumin; CHO-TNFΔ[1-12]; Chinese Hamster Ovary cells transfected with TNFΔ[1-12]; DKO MEF; mouse embryonic fibroblasts from TNFR1-/-/TNFR2-/- mice; EEA1; early endosomal antigen 1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling

Keywords: Akt; Cyclin; GAIP; PI3K; RGS19

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Dual blockade of phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer

Keywords: Paclitaxel; PI3K; MAPK; p70S6 Kinase; Colorectal cancerPI3K, phosphatidylinositol 3′-kinase; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; PTEN, phosphatase and tensin homologue; 5-FU, 5-fluoropyrimidine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

Keywords: 4E-BP1; 4E binding protein 1; 5′UTR; 5′ untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5′-AMP-activated protein kinase; AMPK α1−/−; AMPK α1 subunit knockout; AMPKα1−/−α2−/−; A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway

Keywords: AMPA; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CCK-8; Cell Counting Kit-8; CREB; cAMP response element binding protein; DTNB; 5,5′-dithio-bis (2-nitrobenzoic acid); ERK; extracellular signal-regulated kinases; JNK; c-Jun N-terminal protein

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer

Keywords: Ovarian carcinoma; genetics; epigenetic; targeted therapeutics; BRCA1; EGFR; PI3K

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

Keywords: reeler; synapse; hippocampus; NMDA receptor; PTEN; ApoER2; apolipoprotein E receptor 2; CA1; cornu ammonis area 1; CoIP; co-immunoprecipitation; ECL; enhanced chemiluminescence; HEPES; 4-(2-hydroxyethyl)-piperazine-1-ethanesulphonic acid; IgG; immunoglobu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3-kinase signaling pathway

Keywords: collagen VI; neuroprotection; UV; Akt/PI3K; NeurotoxQ; DAPI; 4′-6-diamidino-2-phenylindole; ECM; extracellular matrix; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GFAP; glial fibrillary acidic protein; JNK; jun N-terminal kinase; MAP-2; microtubule

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors

Keywords: (S)-3-Aminopyrrolidine; Abl; PI3K; K562; Dual kinase inhibitor

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Fluorescent adducts formed by reaction of oxidized unsaturated fatty acids with amines increase macrophage viability

Keywords: HHE; 4-hydroxyhexenal; HNE; 4-hydroxynonenal; AA; arachidonic acid; AOP-LDL; arachidonate oxidation product-modified LDL; apo; apolipoprotein; BHT; butylated hydroxytoluene; ESI; electrospray ionization; FBS; fetal bovine serum; isoLG; isolevuglandin; LA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

Keywords: Pancreatic cancer; PP2A; JNK; PI3K; Akt; PKC;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Activation of STAT1 is required for interferon-alpha-mediated cell death

Keywords: Interferon; Apoptosis; STAT; Deguelin; PI3K; Rapamycin; mTOR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Keywords: AMPK; AMP-activated protein kinase; HEK293; human embryo kidney 293 cells; IIS; insulin/insulin-like signaling; IRS; insulin receptor substrate; MAPK; mitogen activated protein kinase; PGC-1α; PPARγ general co-activator 1α; PI3K; phosphoinositide 3-kin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis

Keywords: Bax; Bcl-2-associated X protein; BCC; Basal cell carcinoma; Bcl-2; B cell lymphoma; Bcl-xL; B-cell lymphoma-extra large; BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; CMM; Cutaneous malignant melanoma; CBP; cyclic-AMP response element

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells

Keywords: Prostate cancer stem cell; PI3K; AKT; PTEN;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Rab GTPases implicated in inherited and acquired disorders

Keywords: ER; endoplasmic reticulum; EEA; early endosome antigen; GDP; guanosine diphosphate; GDI; GDP dissociation inhibitor; GEF; guanine exchange factor; GAP; GTPase activating protein; GLUT4; glucose transporter 4; GTP; guanosine triphosphate; MAPK; mitogen act

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

Keywords: AEN; aminoethyl nitrate; ALDH; aldehyde dehydrogenase; ALDH1A1; cytosolic aldehyde dehydrogenase; ALDH2; mitochondrial low-Km aldehyde dehydrogenase 2; CYP2E1; ethanol-inducible cytochrome P450 2E1 isozyme; DIGE; fluorescence 2-D difference in gel electro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST)

Keywords: Gastrointestinal stromal tumor (GIST); KIT; Platelet derived growth factor receptor alpha (PDGFRA); BRAF; PI3K; PIK3CA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

PKCθ activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades

Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; GI; gastrointestinal; CCK-JMV; CCK-JMV-180; IP; immunoprecipitation; Co-IP; co-immunoprecipitation; PKD; protein kinase D; GPCR; G protein-coupled receptor; PYK2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature

Keywords: bHLH; basic helix-loop-helix; BSA; bovine serum albumin; CMV; cytomegalovirus; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; FBS; foetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HS; horse serum; IGF-1; Insulin-li

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting autophagy during cancer therapy to improve clinical outcomes

Keywords: AMPK; AMP activated protein kinase; ATG; autophagy-related genes; Bif-1; endophilin B1; BNIP3; Bcl-2/adenovirus E1B 19 kDa-interacting protein; CML; chronic myeloid leukemia; CQ; chloroquine; DAP1; death-associated protein 1; HCQ; hydroxychloroquine; HDA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

The multiple roles of amphiregulin in human cancer

Keywords: AREG; amphiregulin; TACE; tumor-necrosis factor-alpha converting enzyme; ADAM; a disintegrin and metalloproteinase; CTF; carboxy-terminal fragment; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFR-TKI; epidermal growth factor rec

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Annexin A6-Linking Ca2+ signaling with cholesterol transport

Keywords: AA; arachidonic acid; AnxA; annexin group A; BCC; breast cancer cells; cav-1; caveolin-1; cPLA2; cytoplasmic phospholipase A2; CHO; Chinese Hamster Ovary; DRM; detergent resistant membranes; EGFR; epidermal growth factor receptor; eNOS; endothelial nitric

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

The emergence of designed multiple ligands for neurodegenerative disorders

Keywords: ACh; acetylcholine; A2A; adenosine receptor subtype two-A; Aβ; amyloid-beta; ACE; angiotensin converting enzyme; BDNF; brain derived neurotrophic factor; GDNF; glial derived neurotrophic factors; MAO-B; monoamine oxidase B; AChE; acetylcholinesterase; AP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

DARPP-32 Increases Interactions Between Epidermal Growth Factor Receptor and ERBB3 to Promote Tumor Resistance to Gefitinib

Keywords: Stomach Cancer; Treatment; PI3K; AKT; Drug Resistance; PPP1R1B; Dopamine Signaling; DARPP-32; dopamine and adenosine 3′, 5′-cyclic monophosphate-regulated phosphoprotein, Mr 32000; EGFR; epidermal growth factor receptor; GSK; glyocogen synthase kina

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells

Keywords: ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain

Keywords: insulin-like growth factor-1; intranasal administration; LPS; oligodendrocyte; apoptotic cell death; inflammatory cytokine; APC-CC1; adenomatous polysis coli (clone CC1); BBB; blood brain barrier; FB; front brain; IGF-1; insulin-like growth factor-1; IL-1

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

PI3K/mTOR signaling regulates prostatic branching morphogenesis

Keywords: Prostate; Branching morphogenesis; PI3K; mTOR; Migration

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

Keywords: Steatosis; Cell Death; Pancreatitis; Hepatitis Virus; AT; α1-antitrypsin; Atg; autophagy-related gene; ATP; adenosine triphosphate; CMA; chaperone-mediated autophagy; ER; endoplasmic reticulum; HBx; hepatitis B virus protein X; LAMP-2; lysosome-associate

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Signal-transduction networks and the regulation of muscle protein degradation

Keywords: 15(S)-HETE; 15(S)-hydroxyeicosatetraenoic acid; ACh; acetylcholine; Akt; protein kinase B; CNTF; ciliary neurotrophic factor; EGF; epidermal growth factor; FGF; fibroblast growth factor; FOXO; forkhead transcription factor; Grb2; growth factor receptor bo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2

Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AC; adenylate cyclase; AGC; cAMP-dependent protein kinase A/protein kinase G/protein kinase C; BMM; bone marrow-derived macrophages; CAPE; caffeic acid phenethyl ester; COX; cyclooxygenase; cPLA2; cytosolic pho

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways

Keywords: CREB; cAMP-response element-binding protein; DA; dopamine; DAT; dopamine transporter; DOPAC; 3,4-dihydroxyphenylacetic acid; ERK; extracellular signal-regulated kinase; GPER1; G protein-coupled estrogen receptor 1; GSK3β; glycogen synthase kinase 3β; HV

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics

Keywords: IL-2; interleukin-2; SILAC; stable isotope labeling of amino acids in cell culture; IP; immunoprecipitation; pTyr; phosphotyrosine; PTK; protein tyrosine kinase; JAK; Janus Kinase; MAPK; mitogen-activated protein kinase, SHP-2, SH2-containing phosphatase;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه