دانلود مقالات ISI درباره PI 3-کیناز + ترجمه فارسی

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1

Keywords: PI 3-کیناز; Histone acetylation; Insulin signalling; HDACi; Sodium butyrate; L6 myotubes; FFAs; free fatty acids; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACi; histone deacetylase inhibitor; HK2; hexokinase 2; NaBut; sodium butyrate; PI 3-kinase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Phosphatidylinositol 4-phosphate 5-kinase α contributes to Toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid

Keywords: PI 3-کیناز; GFP; green fluorescent protein; IκB; inhibitor of κB; IL; interleukin; iNOS; inducible nitric oxide synthase; JNK; c-Jun N-terminal kinase; KD; knockdown; KO; knockout; LPS; lipopolysaccharide; LTA; lipoteichoic acid; MAPK; mitogen-activated protein kin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Sn- and Ge- triorganometallics exert different cytotoxicity and modulation of migration in triple-negative breast cancer cell line MDA-MB-231

Keywords: PI 3-کیناز; APL; acute promyelocytic leukemia; BSA; bovine serum albumin; DHA; docosahexaenoic acid; DMSO; dimethylsulfoxide; ER; estrogen receptor; FDA; fluorescein diacetate; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; HER-2; human epidermal growth fac

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Keywords: PI 3-کیناز; Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

PTEN inhibitors: An evaluation of current compounds

Keywords: PI 3-کیناز; Phosphatase; Enzyme; Inhibitor; Drug; PI 3-Kinase; PTEN; Phosphoinositide;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Signaling specificity in the Akt pathway in biology and disease

Keywords: PI 3-کیناز; Akt; PI 3-Kinase; Signaling; Cancer; Nucleus; Protein kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Keywords: PI 3-کیناز; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt substrate of 160 kDa; GAP; GTPase-activating protein; GLUT; glucose transporter; PAS; phospho-Akt substrate; PI 3-kinase; phosphoinositide 3-kinas

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

Keywords: PI 3-کیناز; Anticancer; Antitumor; PI 3-kinase; Synthesis; ZSTK474;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function

Keywords: PI 3-کیناز; CK2; PI 3-kinase; Akt; Thromboxane; Platelet

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells

Keywords: PI 3-کیناز; corneal endothelial cells; endothelial mesenchymal transformation; retrocorneal fibrous membrane; FGF-2; PI 3-kinase; IL-1β; Rho kinases; type I collagen; p27

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells

Keywords: PI 3-کیناز; BSA; bovine serum albumin; cAMP; cyclic AMP; ChIP; chromatin immunoprecipitation; C/EBPβ; CCAAT/enhancer-binding-protein-beta; CM; conditioned medium; COX-2; cyclooxygenase-2; CREB; cAMP response element binding protein; EP; prostaglandin E receptor; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway

Keywords: PI 3-کیناز; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; IGF; insulin-like growth factor; IGF-IR; type 1 IGF receptor; IR; insulin receptor; IRS; insulin receptor substrate; PI 3-kinase; phosphatidylinositol

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma

Keywords: PI 3-کیناز; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; EMT; epithelial-mesenchymal transition; T790M; threonine-to-methionine mutation at codon 790 of EGFR; p-MET; phosphorylation of MET; p-Akt; phosphorylation of Akt; IHC; immunohistoc

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Shooting the messenger: Targeting signal transduction pathways in leukemia and related disorders

Keywords: PI 3-کیناز; Leukemia; Myeloproliferative disorders; Signaling pathways; Therapeutics; BCR-ABL; JAK2; STAT5; PI 3-kinase; HDAC

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

Keywords: PI 3-کیناز; Leptin; Synaptic transmission; NMDA receptor; Synaptic plasticity; PI 3-kinase; MAPK

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

Keywords: PI 3-کیناز; Cannabinoids; Cannabinoid receptors; Food intake; Obesity; Insulin secretion; Islets of Langerhans; β-cells; AC; adenylate cyclase; ACEA; N-(2-chloroethyl)5,8,11,14-eicosaetraenamide; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; AM251

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells

Keywords: PI 3-کیناز; Akt; IL-6; Lyn; Myeloma; PI 3-kinase; Proliferation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate

Keywords: PI 3-کیناز; IGF-I; insulin-like growth factor I; siRNA; small interfering RNA; IGF-IR; IGF-I receptor; PI 3-kinase; phosphatidylinositol 3-kinase; PIP3; phosphatidylinositol 3,4,5-triphosphate; F-actin; actin filament; CLIP; cytoplasmic linker protein; CLAPS; CLIP-as

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Activation of PI 3-kinase/Akt/NF-κB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis

Keywords: PI 3-کیناز; Avian reovirus S1333; Pro-inflammatory cytokine; Apoptosis; PI 3-kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of autophagy by phosphatidylinositol 3-phosphate

Keywords: PI 3-کیناز; Autophagy; Phosphoinositide; Signalling; Endoplasmic reticulum; PI 3-Kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-β-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase

Keywords: PI 3-کیناز; AMF/PGI; TGF-β; PI 3-kinase; Akt; STAT3

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

Phosphoinositides and the endocytic pathway

Keywords: PI 3-کیناز; Endocytosis; Phosphoinositide; EEA1; Hrs; Sorting nexin; PI 3-kinase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation

Keywords: PI 3-کیناز; PI 3-kinase; Adipocyte differentiation; PI3K isoform-specific inhibitors; Signal transduction; PIK3CA; Off-target activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

Keywords: PI 3-کیناز; Insulin resistance; YM201636; PIKfyve; Antiretroviral therapy; Glucose transport; GLUT4; PI 3-kinase; Insulin action

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Functional differences between two classes of oncogenic mutation in the PIK3CA gene

Keywords: PI 3-کیناز; PI 3-kinase; Cancer; PI-103; PIK-75; Ras; p110α;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Autophagy in tumour suppression and promotion

Keywords: PI 3-کیناز; Apoptosis; Autophagy; Beclin 1; Carcinogenesis; Genome instability; Lysosome; PI 3-kinase; Survival; Reactive oxygen species; UVRAG;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

The role of cell adhesion pathways in angiogenesis

Keywords: PI 3-کیناز; ECM; extracellular matrix; EC; endothelial cell; VSMC; vascular smooth muscle cell; VEGF; vascular endothelial growth factor; VEGFR-2; vascular endothelial growth factor receptor-2; FAK; focal adhesion kinase; PI 3-kinase; phosphoinositide 3-kinase; PLC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Cadmium and cellular signaling cascades: To be or not to be?

Keywords: PI 3-کیناز; Apoptosis; ER stress; Calmodulin; PI 3-kinase; ERK; p38-MAPK; JNK; Phosphodiesterase; Ca2+-sensing receptor; Wnt/β-catenin; Hedgehog

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2009 سفارش ترجمه

Baicalein suppresses hypoxia-induced HIF-1α protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells

Keywords: PI 3-کیناز; Baicalein; Hypoxia; BV2 microglia; HIF-1α; PI 3-kinase; ROS;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through phosphatidylinositol 3-kinase signal pathway

Keywords: PI 3-کیناز; FIP, fungal immunomodulatory protein; gts, Ganoderma tsugae; IFN-γ, interferon-gamma; fve, Flammulina velutipes; HPBMCs, human peripheral blood mononuclear cellsFungal immunomodulatory protein; IFN-γ; PI 3-kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells

Keywords: PI 3-کیناز; A-T; Ataxia-telangiectasia; IR; Insulin receptor; IRS-1; Insulin receptor substrate 1; ATM; A-T mutated; PI 3-kinase; Phosphotidylinositol 3-kinase; GLUT4; Glucose transporter 4; QUICKI; Quantitative Insulin Sensitivity Check Index; GFP; Green fluorescenc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines

Keywords: PI 3-کیناز; PI 3-kinase; Muc4; ErbB2; ErbB3; Adenocarcinomas

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

SWAP-70 is required for oncogenic transformation by v-Src in mouse embryo fibroblasts

Keywords: PI 3-کیناز; PI 3-kinase; SWAP-70; Anchorage-independent growth; v-Src; Transformation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Keywords: PI 3-کیناز; Kinases; PDK-1; AKT; PI 3-kinase; Cancer; Antitumor agent

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1

Keywords: PI 3-کیناز; age-related macular degeneration; GTPase signaling; Rac1; PI 3-kinase; endothelial; cell migration; choroidal endothelial cell

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα

Keywords: PI 3-کیناز; PI 3-kinase; phosphoinositide 3-kinase; PKB; protein kinase B; PDK-1; phosphoinositide-dependent kinase-1; PKC; protein kinase C; mTOR; mammalian target of rapamycin; c48/80; compound 48/80; BAPTA; bis-(o-aminophemoxy)-ethane-N,N,N′,N′-tetraacetic aci

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

Keywords: PI 3-کیناز; Bruton's tyrosine kinase; PI 3-kinase; Toll-like receptor-2; Lipoteichoic acid;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways

Keywords: PI 3-کیناز; Ras; Non-apoptotic cell death; Vacuoles; Glioblastoma; Raf; PI 3-Kinase; Farnesylation; Autophagy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of β2-adrenergic receptors

Keywords: PI 3-کیناز; PI 3-kinase; β2-adrenergic receptors; rab7; Lysosomes; Endosomes

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells

Keywords: PI 3-کیناز; Manganese; iNOS; PI 3-kinase; MAPK; BV2 microglial cells; Luciferase assay

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis

Keywords: PI 3-کیناز; Platelet; Nitrotyrosylation of protein; Systemic sclerosis; Nitric oxide synthase; Collagen; PI 3-kinase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-α production through inhibition of PI 3-kinase/Akt and NF-κB activation in murine BV2 microglial cells

Keywords: PI 3-کیناز; Adenosine A3 receptor; BV2 microglial cells; LPS; TNF-α; PI 3-kinase; NF-κB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

PIKE GTPase-mediated nuclear signalings promote cell survival

Keywords: PI 3-کیناز; PIKE GTPase; PI 3-kinase; Phosphatidylinositol; Phosphorylation; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

FGF-2-mediated signal transduction during endothelial mesenchymal transformation in corneal endothelial cells

Keywords: PI 3-کیناز; corneal endothelial cells; FGF-2; PI 3-kinase; IL-1β; Rho kinases; actin cytoskeleton; type I collagen; endothelial mesenchymal transformation; wound healing

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides

Keywords: PI 3-کیناز; ELISA; PTEN; PI 3-kinase; Phosphoinositide; Pleckstrin homology domain; FYVE finger domain

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

TRB3 is a PI 3-kinase dependent indicator for nutrient starvation

Keywords: PI 3-کیناز; TRB3; PI 3-kinase; Starvation; Nutrition status; Tribbles

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils

Keywords: PI 3-کیناز; AIF; apoptosis-inducing factor; AMC; aminomethylcoumarin; ATA; aurintricarboxylic acid; CMXRos; cloromethyl-X-rosamine; mClCCP; carbonyl cyanide m-chlorophenylhydrazone; DiBAC4(3); bis-(1-3-dibutylbarbituric acid) trimethine oxonol; EndoG; endonuclease G;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells

Keywords: PI 3-کیناز; PI 3-kinase; phosphoinositol 3-kinase; PIP3; phosphoinositol 3,4,5-trisphosphate; NF-κB; nuclear factor-kappaB; PTEN/MMAC; phosphatase and tensin homologue/mutated in multiple advanced cancers; PDTC; pyrrolidine dithiocarbamate; Dimethylsulfoxide; PTEN;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

Keywords: PI 3-کیناز; JNK; PI 3-kinase; mTOR; IRS-1; Serine 318; C2C12 myotubes; Insulin resistance;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Role of Krüppel-like factor 15 in PEPCK gene expression in the liver

Keywords: PI 3-کیناز; Gene expression; Insulin action; Liver; KLF15; PI 3-kinase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه