کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326110 | 1539955 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of cell adhesion pathways in angiogenesis
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کلمات کلیدی
PLCRTKPECAM-1VSMCVEGFR-2FGF-2PKCECMFAKCOX-2NF-κBplatelet-endothelial cell adhesion molecule-1PI 3-kinase - PI 3-کینازAngiogenesis - آنژیوژنزIntegrin - اینتگرینVascular smooth muscle cell - سلول عضله صاف عروقیEndothelial cell - سلول های اندوتلیالCyclooxygenase-2 - سیکلوکوکسیژناز2Intracellular signaling - سیگنال درون سلولیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Nuclear factor-kappa B - فاکتور هسته ای-کاپا Bphospholipase C - فسفولیپاز Cphosphoinositide 3-kinase - فسفینوزیتید 3-کینازfibroblast growth factor-2 - فیبروبلاست رشد فاکتور 2Extracellular matrix - ماتریکس خارج سلولیProtein kinase C - پروتئین کیناز سیCell adhesion - چسبندگی سلولیfocal adhesion kinase - کیناز چسبندگی کانونیVascular endothelial growth factor receptor-2 - گیرنده 2 فاکتور رشد اندوتلیال عروقیReceptor Tyrosine Kinase - گیرنده تیروزین کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of cell adhesion pathways in angiogenesis The role of cell adhesion pathways in angiogenesis](/preview/png/8326110.png)
چکیده انگلیسی
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is prevalent both during normal mammalian development and in certain pathological conditions such as tumor growth. It is stimulated and controlled by a complex network of intracellular signaling mechanisms, many of which are initiated by trans-membrane receptors transducing signals received from other cells and from the extracellular environment. Of these, cytokine signaling is recognized as one of the primary drivers of angiogenesis, but it has become increasingly evident that signaling mechanisms generated as a result of cell adhesion interactions are also crucially important. In addition, cell adhesion pathways are also intimately tied to cytokine signaling often making it difficult to dissect out the relative contribution of each to a particular angiogenic step. Many of these same signaling mechanisms are often manipulated by tumors to stimulate aberrant angiogenesis and enhance their blood supply. As a consequence, there is a great deal of interest in trying to understand the full complement of intracellular signaling pathways in angiogenesis as well as their interplay and timing during the process. Ultimately, understanding the complex network of signaling pathways that function during angiogenesis will provide important avenues for future therapeutic development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 3, March 2009, Pages 521-530
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 3, March 2009, Pages 521-530
نویسندگان
Antoine R. Ramjaun, Kairbaan Hodivala-Dilke,