Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel
Keywords: TRPM1 channel; Binding site; PIP2; Surface plasmon resonance; FRET; Circular dichroism;
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A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches
Keywords: PI3K; phosphatidylinositide 3-kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; ASA; accessible surface area; ÎASA; lo
Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications
Keywords: CAK β; cell adhesion kinase-β; CREB; cyclic AMP response binding protein; DAG; diacylglycerol; ER; endoplasmic reticulum; GKAP; guanylate kinase associated protein; Gq/Gq11; guanine nucleotide binding protein q/q11; IP3; inositol 1,4,5 trisphosphate; NM
Autophagy in zebrafish
Keywords: 3MA; 3-methyladenin; AC; adenylyl cyclase; AMPK; adenosine monophosphate-dependent kinase; Atg; autophagy related gene; BafA1; Bafilomycin A1; CMV; cytomegalovirus; CQ; chloroquine; dpa; days post amputation; dpf; days post fertilization; ERK; extracellul
PIP2 and PIP3 interact with N-terminus region of TRPM4 channel
Keywords: TRPM4 channel; PIP2; Binding site; Surface plasmon resonance; Molecular modeling; Circular dichroism;
Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations
Keywords: EGFR; Juxtamembrane domain; PIP2; Molecular dynamics; Lipid bilayer;
Lipid agonism: The PIP2 paradigm of ligand-gated ion channels
Keywords: AA; arachidonic acid; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; BK; big conductance potassium channel; Cav; voltage-dependent calcium channel or VDCC; Ci-VSP; Ciona intestinalis voltage-sensitive phosphatase; CoA; coenzyme A; CTD; cytop
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z
Purification, sequencing and characterization of phospholipase D from Indian mustard seeds
Keywords: BSA; bovine serum albumin; Ca2+-HIC; Ca2+-mediated hydrophobic interaction chromatography; EDTA; ethylenediamine tetraacetic acid; HEPES; 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid; lyso-PC; lysophosphatidylcholine; MES; 2-(N-morpholino)ethanesulf
PI3K/Akt signaling in osteosarcoma
Keywords: OS; osteosarcoma; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; IGF1R; insulin-like growth factor 1 receptor
Study of PTEN subcellular localization
Keywords: AKAP; A kinase anchoring protein; ArA; arachidonic acid; Ca2+; calcium; CLS; cytoplasmic localization signal; Co-IP; co-immunoprecipitation; COX; cytochrome c oxidase; ER; endoplasmic reticulum; ER-RFP; endoplasmic reticulum-targeted red fluorescent prote
Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues
Keywords: OT; oxytocin; OTR; oxytocin receptor; MAPK; mitogen activated protein kinase; PG; prostaglandin; PKC; protein kinase C; PLC; phospholipase C; PIP2; phosphatidylinositol 4,5-bisphosphate; IP3; inositol trisphosphate; DAG; diacyl-glycerol; OVT; ornithine va
CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis
Keywords: AI; auto-inhibitory; CCT; CTP:phosphocholine cytidylyltransferase; CCTsol; soluble form of CCT; CCTmem; membrane-bound form of CCT; CT; cytidylyltransferase; ECT; ethanolamine-phosphate cytidylyltransferase; ERK; extracellular signal-regulated kinase; GCT
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells
Keywords: AMPK; AMP-activated protein kinase; ACC; Acyl COA Carboxylase; BSA; Bovine Serum Albumin; DHE; Dihydroethidium; DPI; Diphenylene iodonium; ERK; Extracellular signal-regulated kinase; FAS; Fatty Acid Synthase; FBS; Fetal bovine serum; FOXO1; Forkhead box p
Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase γ by Akt regulates its interaction with talin and focal adhesion dynamics
Keywords: EGF; epidermal growth factor; FAs; focal adhesions; PIP2; phosphatidylinositol 4,5-bisphosphate; PIP5Kγ90; phosphatidylinositol 4-phosphate 5-kinase γ 90 kDa; S555; serine 555; WT; wild-type; Phosphatidylinositol 4-phosphate 5-kinase γ; Phosphatidylin
Dual effects of the non-esterified fatty acid receptor 'GPR40' for human health
Keywords: AA; arachidonic acids; ABCD; ABC transporters; BDNF; brain-derived neurotrophic factor; BKCa channels; Ca2+-activated K+ channels; cAMP; cyclic AMP; CO; carbon monoxide; CLA; conjugated linoleic acids; CNS; central nervous system; CoA; coenzyme A; CREB; c
Fast endocytic recycling determines TRPC1-STIM1 clustering in ER-PM junctions and plasma membrane function of the channel
Keywords: STIM1; Stromal interaction molecule 1; ER; Endoplasmic reticulum; PM; Plasma membrane; TRPC1; Transient receptor potential canonical 1; Arf6; ADP-ribosylation factor 6; [Ca2Â +]i; cytosolic Ca2Â + concentration; SOCE; Store-operated calcium entry; PIP2; p
Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2
Keywords: BCR; B cell receptor; CRAC; Ca2+-release activated Ca2+; PIP2; phosphatidylinositol-4,5-bisphosphate; IP3; inositol-1,4,5,-triphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; PLC-γ2; phospholipase-γ2; PI3K; phosphoinositide 3-kinase; EAE; expe
Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components
Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4
Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice
Keywords: A-SMase; acidic sphingomyelinase; CHS; Chediak-Higashi syndrome; Con A; concanavalin A; DAG; diacylglycerol; diC8; sn-1,2-dioctanoylglycerol; 2,3-DPG; 2,3-diphosphoglycerate; FAN; factor associated with neutral sphingomyelinase activation; FITC; fluores
An integrated mechanism of cardiomyocyte nuclear Ca2Â + signaling
Keywords: Ang II; angiotensin II; E-C; excitation-contraction; ER; endoplasmic reticulum; ET-1; endothelin-1; IGF-1; insulin-like growth factor-1; INM; inner nuclear membrane; InsP3; inositol 1,4,5-trisphosphate; InsP3R; InsP3 receptor; NE; nuclear envelope; ON
A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo
Keywords: Cold; Pain; Adaptation; Thermosensation; Phospholipase C; PIP2; TRPM8; TRPA1; Heat;
Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor
Keywords: Lateral amygdala; Serotonin; TRPC; GIRK; PIP2; PI3-kinase;
PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance
Keywords: PIP2; actin-binding proteins; HIV-1
Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels
Keywords: PIP2; phosphatidylinositol 4,5-bisphosphate; KATP channels; ATP-sensitive K+ channels; SUR; sulfonylurea receptor; Syn-1A; syntaxin-1A; PM; plasma membrane; FRET; fluorescence resonance energy transfer; Kir; potassium inward rectifiers; PLC; phospholipase
Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication
Keywords: aCSF; artificial cerebrospinal fluid; Akt; serine/threonine protein kinase; EMSA; electrophoretic mobility shift assay; HR; heart rate; LF; low-frequency; 3-MA; 3-methyladenine; NF-κB; nuclear factor-κB; NO; nitric oxide; NOS; nitric oxide synthase; NRS
NHERF1/EBP50 Controls Morphogenesis of 3D Colonic Glands by Stabilizing PTEN and Ezrin-Radixin-Moesin Proteins at the Apical Membrane
Keywords: 3D; three-dimensional; CIP; calf intestinal phosphatase; IF; immunofluorescence; CRC; colorectal cancer; ERM; ezrin-radixin-moesin; NF2; neurofibromatosis type 2; NHERF1/EBP50; Na+/H+ exchanger 3 regulating factor 1/ERM-binding phosphoprotein 50; pHH3; ph
Systems biology of synaptic plasticity: A review on N-methyl-d-aspartate receptor mediated biochemical pathways and related mathematical models
Keywords: AC; adenylyl cyclase; AKAP; A-kinase anchoring protein; AMPAR; A-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; CaM; calmodulin; CaMKII; Ca2+/CaM-dependent protein kinase II; cAMP; cyclic adenosine monophosphate; HFS; high frequency stimula
Gene expression profile analysis of Ligon lintless-1 (Li1) mutant reveals important genes and pathways in cotton leaf and fiber development
Keywords: ACO; 1-aminocyclopropane-1-carboxylic acid oxidase; ADNI1; adenine nucleotide transporter 1; ALDH; aldehyde dehydrogenase; AP2; AP2-EREBP transcription factors; AS1; ASYMMETRIC LEAVES1; AS2; ASYMMETRIC LEAVES2; ATSS3; Arabidopsis starch synthase 3; ATBFRU
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
Keywords: RAS; renin-angiotensin system; AOG; angiotensinogen; Ang II; angiotensin II; ACE; angiotensin converting enzyme; ARBs; angiotensin AT1 receptor blockers; Mas R; Mas receptor; TGF-β; transforming growth factor-β; Ang A; angiotensin A; eNOS; endothelial
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua
Integrin clustering as a result of local membrane deformations and local signaling feedbacks
Keywords: Monte-Carlo; Spatial distribution; Aggregation; Integrin; Talin; PIP2
NFAT as cancer target: Mission possible?
Keywords: ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin
Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters
Keywords: PH; pleckstrin homology domain; ABD; actin binding domain; SH3; SRC homology 3 domain; EF-hand domain; calcium-binding domain; PIP2; Phosphatidylinositol 4,5-bisphosphate; CH1; calponin homology domain; PKA; Protein Kinase-A; cAMP; 3â²-5â²-cyclic adenos
The structural basis of action of vanadyl (VO2+) chelates in cells
Keywords: acac; acetylacetonate, as in bis(acetylacetonato)oxidovanadium(IV) or VO(acac)2; alx; allixin; ASP; acylation-stimulating protein; CHO; Chinese hamster ovary; ENDOR; electron nuclear double resonance; EGFR; epidermal growth factor receptor; EPR; electron
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells
Keywords: BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ concentration; DMEM; Dulbecco's Modified Eagle Medium; DNP; dinitrophenol; FBS; foetal bovine serum; FcεRI; high-affinity IgE receptor; HRP; horseradish peroxidase; HSA; human serum albumin; IgE; i
PIP2 hydrolysis is responsible for voltage independent inhibition of CaV2.2 channels in sympathetic neurons
Keywords: Calcium channel regulation; CaV2.2 channel; SCG neuron; Voltage independent inhibition; PIP2; diC8-PIP2;
Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation
Keywords: Glycyrrhizic acid; 18β-Glycyrrhetinic acid; Glucocorticoid receptor; Phosphoinositide 3-kinase; Glucocorticoid resistance; 18βGA; 18β-glycyrrhetinic acid; Akt; protein kinase B; AP1; activator protein 1; COPD; chronic obstructive pulmonary disease; CRE
Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents
Keywords: lipid raft; receptor; Kv7/M current; modulation; specificity; B2R; bradykinin receptor; BK; bradykinin; DRG; dorsal root ganglion; EC50; 50% effective concentration; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; GPCR; G pr
The two faces of the pharmacological interaction of mGlu2 and 5-HT2A - Relevance of receptor heterocomplexes and interaction through functional brain pathways
Keywords: G-protein coupled receptor; GPCR; Metabotropic glutamate receptor 2 (mGlu2); 5-Hydroxytryptamine receptor 2A (5-HT2A); Heteromerization; Functional receptor interaction; Receptor cross-talk; Schizophrenia; 5-HT; 5-hydroxytryptamine; 5-HT2A; serotonin rece
Vinculin and metavinculin: Oligomerization and interactions with F-actin
Keywords: Vinculin; Metavinculin; Actin; PIP2; Oligomerization;
Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation
Keywords: AF; atrial fibrillation; AP; action potential; APD; AP duration; cAF; chronic AF; CCh; carbachol; ICa,L; L-type Ca2Â + current; IK1; basal inward-rectifier K+ current; IK,ACh; muscarinic-receptor-activated K+ current; INaK; Na+-K+ ATPase current; [Na+]i;
Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway
Keywords: HLJDD; Huang-Lian-Jie-Du-Decotion; MCAO; middle cerebral artery occlusion; TTC; 2,3,5-triphenyltetrazolium chloride; HE; hematoxylin-eosin; NO; nitric oxide; MDA; malondialdehyde; GSH; glutathione; GSSG; glutathione disulfide; T-SOD; total superoxide di
Regulation of sperm motility by PIP2(4,5) and actin polymerization
Keywords: Sperm; Motility; PIP2; Gelsolin;
Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H+ and ROS concentrations
Keywords: EF(s); Electric field(s); LEF; Low electric fields; ROS; Reactive oxygen species; H2DCF-DA; Dichlorodihydrofluorescein diacetate; DHA; Dehydroascorbic acid; RTK; Receptor tyrosine kinase; PTPs; Protein tyrosine phosphatases; DC; Direct current; FITC; Fluo
Regulation of CaV2 calcium channels by G protein coupled receptors
Keywords: Calcium channel; G protein coupled receptor; Gβγ; Tyrosine kinase; PiP2; Arachidonic acid;
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore
Keywords: Propafenone; Human atrial myocytes; IK1; PIP2; Rectification; Inward rectifier channels
The plant non-specific phospholipase C gene family. Novel competitors in lipid signalling
Keywords: ABA; abscisic acid; BL; 24-epibrassinolide; BY-2; Bright Yellow 2; BODIPY; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D609; tricyclodecan-9-yl-xanthogenate; DAG; diacylglycerol; DGDG; digalactosyldiacylglycerol; DGK; diacylglycerol kinase; EDTA; ethylene