Keywords: PrP; prion protein; PrPC; normal cellular isoform of PrP; PrPSc; abnormal misfolded isoform of PrP; CJD; Creutzfeldt Jakob disease; sCJD; sporadic CJD; dCJD; dura mater graft-associated CJD; p-dCJD; plaque-type dCJD; np-dCJD; non-plaque-type dCJD; 129M/M;
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Keywords: Prion; Biological safety level; Protein; Expression; Purification; Refolding; PrPC; major prion protein of higher animals (cellular form); PrPSC; major prion protein of higher animals (scrapie form); SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel ele
Keywords: AA; amino acid; Aβo; oligomeric β-amyloid; Aβ; β-amyloid; AD; Alzheimer's disease; α7nAChR; α7 nicotinic acetylcholine receptor; ALS; amyotrophic lateral sclerosis; APLP1; amyloid beta precursor-like protein 1; APP; amyloid precursor protein; β-A
Keywords: Aβ; beta-amyloid peptide; AAV; adeno-associated virus; ABAD; amyloid-beta-binding alcohol dehydrogenase; AD; Alzheimer's disease; ALP; autophagy-lysosome pathways; Apaf-1; apoptic protease-activating factor 1; APP; amyloid precursor protein; AICD; APP in
Keywords: α-syn; α-synuclein; Aβ; β-amyloid; AD; Alzheimer's disease; ADAMs; a disintegrin and metalloproteinases; ALS; amyotrophic lateral sclerosis; BSE; bovine spongiform encephalopathy; CJD; Creutzfeldt-Jakob disease; CNS; central nervous system; CSF; cer
Keywords: PrPC; cellular prion protein; PrPSc; aggregated form of prion protein; NTR; N-terminal region; CTD; C-terminal domain; α2; helix 2; α3; helix 3; CD; circular dichroism; FTIR; Fourier transform infrared; DLS; dynamic light scattering; wt; wild-type; SEC;
Keywords: Prion disease; PrPSc; Autophagy; Proteasome; Lysosomal degradation; Therapeutics;
Keywords: PrPC; cellular prion protein; PrPSc; scrapie conformer; DRM; detergent resistant membranes; GPI-AP; glycosylphosphatidylinositol-anchored proteins; ERC; endosomal recycling compartment; ERAD; endoplasmic reticulum associated-proteasomal degradation; RML;
Keywords: PrPC; cellular prion protein; PrPSc; scrapie form of prion protein; [Ca2+]i; intracellular calcium; MPs; microparticles; PMPs; platelet-derived microparticles; Thr; thrombin; PrP; prion peptide; Prion; Platelets; Intracellular calcium; Calpain; Microparti
Keywords: Aβ; amyloid-β peptide; AD; Alzheimer's disease; AFM; atomic force microscopy; ALS; amyotrophic lateral sclerosis; dpi; days post injection; HuPrP; human PrPC; HX-MS; hydrogen/deuterium exchange measured using mass spectrometry; LBs; Lewy bodies; PD; Par
Keywords: Variable domain of heavy-chain antibody; Inhibition of protein misfolding and aggregation; Protein misfolding diseases; Amyloidoses; VHH; Nanobody; Ab; antibody; Aβ; amyloid β-peptide; AD; Alzheimer's disease; ANS; anilino naphthalene-sulfonic acid; AP;
Keywords: Abs; antibodies; Akt; cytoplasmic serine-threonine kinase from Ak mouse strain thymoma; Cbl; cobalamin; Cbl-D; Cbl-deficient; CNS; central nervous system; CSF; cerebrospinal fluid; DMSO; dimethyl sulfoxide; Dpl; Doppel; EGF; epidermal growth factor; GFAP;
Keywords: AA; ascorbic acid; BSE; Bovine spongiform encephalopathies; B3LYP; Becke 3 parameter Lee Yang Parr; BP86; Becke Perdew86; CD; Circular dichroism; CJD; Creutzfeldt-Jakob disease; CPMD; Car-Parrinello molecular dynamics; DFT; Density functional theory;
Residue-specific mobility changes in soluble oligomers of the prion protein define regions involved in aggregation
Keywords: Prion protein; Protein misfolding; Beta oligomer; Solution NMR; PrPSc; infectious particle of misfolded prion protein; PrP; prion protein; PrPc; cellular prion protein; BSE; bovine spongiform encephalopathy; CWD; chronic wasting disease; CJD; Creutzfeldt
Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain
Keywords: Prion disease; PrPSc; Quinacrine; Acridine; Single photon emission computed tomography (SPECT);
Research reportPrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrPsc
Keywords: TSE; transmissible spongiform encephalopathy; BSE; bovine spongiform encephalopathy; PK; proteinase K; PrP; prion protein; PrPres; protease-resistant prion protein; PrPsc; disease-associated PrP; PrPc; normal cellular PrP; NaPTA; sodium phosphotungstic ac
Identification and Structural Characterization of the Precursor Conformation of the Prion Protein which Directly Initiates Misfolding and Oligomerization
Keywords: PrP; prion protein; PrPC; cellular PrP; PrPSc; scrapie PrP; HDX; hydrogen-deuterium exchange; moPrP; mouse PrP; PUF; partially unfolded form; CTD; C-terminal domain; dm CTD; double mutant variant of the C-terminal domain; wt; wild-type; DLS; dynamic lig
The retention of prion protein in the endoplasmic reticulum prevents N2A cells from proteasome inhibition-induced cytotoxicity
Keywords: PrPC; PrPSc; Endoplasmic reticulum; KDEL ER-retention motif; Prion disease;
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
l-Arginine ethylester enhances in vitro amplification of PrPSc in macaques with atypical L-type bovine spongiform encephalopathy and enables presymptomatic detection of PrPSc in the bodily fluids
Keywords: Atypical bovine spongiform encephalopathy; Protein misfolding cyclic amplification; Arginine ethylester; Bodily fluid; Nonhuman primate; PrPSc; Pathogenic form of prion protein; PrPC; cellular prion protein; CJD; Creutzfeldt-Jakob disease; BSE; Bovine s
Reduced expression of the presynaptic co-chaperone cysteine string protein alpha (CSPα) does not exacerbate experimentally-induced ME7 prion disease
Keywords: CSPα; Gliosis; ME7; PrPSc; Synaptic loss;
Proteinase K and the structure of PrPSc: The good, the bad and the ugly
Keywords: Prion; PrPSc; PrPSc structure; Proteinase K; Limited proteolysis; β-Solenoid;
Prion-like features of misfolded Aβ and tau aggregates
Keywords: PMDs; protein misfolding disorders; CNS; central nervous system; AD; Alzheimer's disease; TSEs; transmissible spongiform encephalopathies; PrPSc; disease associated form of the prion protein; PrPC; cellular prion protein; Aβ; amyloid-β; APP; amyloid pre
Are PrPCs involved in some human myelin diseases? Relating experimental studies to human pathology
Keywords: Abs; antibodies; Akt; cytoplasmic serine-threonine kinase from Ak mouse strain thymoma; AT; anti-TNF-α; Cbl; cobalamin; Cbl-D; Cbl-deficient; CNS; central nervous system; CoA; coenzyme A; CSF; cerebrospinal fluid; EGF; epidermal growth factor; GFAP; gl
H ferritin silencing induces protein misfolding in K562 cells: A Raman analysis
Keywords: 2'-7'-DCF; 2'-7'-dichlorodihydrofluorescein; AβP; β-amiloid protein; BCA; bicinchoninic acid; CM-H2CFDA, 5-(and-6)-carboxy-2'; 7'dichlorofluorescein; DCDR; drop coating deposition Raman; EMSC; extended multiplicative signal correction; FHC; ferr
Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation?
Keywords: Prion; de novo; PMCA; Sonication; Cavitation; Free radical; PrP; prion protein; PrPres; protease-resistant isoform of PrP; PrPSc; protease-resistant, infectious isoform of PrP; rPrP; bacterially expressed recombinant PrP; PMCA; protein misfolding cyclic a
Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein
Keywords: CtmPrP; transmembrane form of prion protein with the C-terminus residing in the lumen of endoplasmic reticulum; cytoPrP; cytosolic prion protein; ER; endoplasmic reticulum; GPI; glycosylphosphatidylinositol; GSK-3; glycogen synthase kinase 3; HBSS; Hank's
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-
Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway
Keywords: AMPK; AMP-activated protein kinase; ATG5; autophagy-related 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LDH; lactate dehydrogenase; mTOR; mammalian target of rapamycin; PI; propidium iodide; PrP; pr
Characterization of early transient accumulation of PrPSc in immune cells
Keywords: Prion; PrPSc; Tissue culture; Macrophages; Immune system; Western blot;
Molecular cloning and sequence analysis of prion protein gene in Xiji donkey in China
Keywords: TSEs; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease; vCJD; variant Creutzfeldt-Jakob diseases; BSE; bovine spongiform encephalopathy; CWD; chronic wasting disease; FME; feline spongiform encephalopathy; TME; mink spongiform
Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1
Keywords: PrPC; normal cellular prion protein; PrPSc; disease-associated prion protein; GT1-1 cells; immortalized hypothalamic gonadotropin-releasing hormone neurons; BDNF; brain-derived neurotrophic factor; MEK; mitogen-activated protein kinase kinase; ERK; extrac
Lysine hydroxylation and O-glycosylation in the globular, C-terminal region of mammalian-expressed, recombinant PrP
Keywords: CAD; collisionally activated dissociation; CHO; Chinese hamster ovary; GPI; glycosylphosphatidylinositol; MS; mass spectrometry; MS/MS; tandem mass spectrometry; PRNP; the gene encoding the prion protein; PrPC; cellular prion protein; PrPSc; scrapie isofo
Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo
Keywords: Prion; PrPSc; Cryo-immunogold EM; Plasma membrane; Synapse; Neurodegeneration;
Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells
Keywords: Antiprion compounds; PrPSc; Dividing and stationary-phase brain cells;
Novel assay with fluorescence-labelled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
Keywords: PrP, prion protein; PrPC, cellular prion protein; PrPSc, disease-associated prion protein; BSE, bovine spongiform encephalopathy; C-BSE, classical BSE; L-BSE, L-type atypical BSE; PK, proteinase K; FI, fluorescence indexPrion; PrPSc; Conformational change
Persistence of the bovine spongiform encephalopathy infectious agent in sewage
Keywords: BSE; bovine spongiform encephalopathy; CWD; chronic wasting disease; TSE; transmissible spongiform encephalopathies; PrPc; cellular prion protein; PrPSc; scrapie-associated prion protein; PrPRes; protease-resistant prion protein; Prions; BSE; PrPRes; Infe
Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains
Keywords: PrPSc; PrP-scrapie; PrPC; normal cellular PrP; Tf; transferrin; Cp; ceruloplasmin; Prions; Ferritin; Iron imbalance; Aggregation; Neurotoxicity;
Cobalamin (vitamin B12) regulation of PrPC, PrPC-mRNA and copper levels in rat central nervous system
Keywords: Abs; antibodies; ANOVA; analysis of variance; AT; anti-TNF-α; C; cervical; Cbl; cobalamin; Cbl-D; Cbl-deficient; CNS; central nervous system; CSF; cerebrospinal fluid; Ct; cycle threshold; H; the 6H4 region of the normal prion molecule; ECL; enhanced che
Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice
Keywords: PrPc; cellular prion protein; PrPSc; prion protein scrapie; rAd; recombinant adenovirus; TSE; transmissible spongiform encephalopathy; AA; amino acid; Wt; wild-type; CTL; cytotoxic T lymphocytes; CNS; central nervous system; OligoCpG; oligodeoxy nucleotid
Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells
Keywords: Prion diseases; Transmissible spongiform encephalopathies; Anti-prion compound; 2,3,4,9-Tetrahydro-1H-carbazole; Ring-opening reaction; Structure-activity relationships; TSEs; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease;
Alteration of the endocannabinoid system in mouse brain during prion disease
Keywords: prion; endocannabinoid; cannabinoid receptor; neurodegenerative disease; brain; mouse; AEA; arachidonoylethanolamide or anandamide; CBD; cannabidiol; CBR; cannabinoid receptor; CJD; Creutzfeldt-Jakob disease; GAPDH; glyceraldehyde-3-phosphate dehydrogenas
Salt bridges in prion proteins are necessary for high-affinity binding to the monoclonal antibody T2
Keywords: BSE; bovine spongiform encephalopathy; CD; circular dichroism; ka; association rate constant; kd; dissociation rate constant; KD; dissociation constant; PAGE; polyacrylamide gel electrophoresis; PrP; prion protein; PrPC; cellular prion protein; PrPSc; abn
Tau inhibits tubulin oligomerization induced by prion protein
Keywords: AD; Alzheimer disease; CBB; Coomassie brilliant blue; CtmPrP; transmembrane form of prion protein with the C-terminus residing in the lumen of endoplasmic reticulum; cytoPrP; cytosolic prion protein; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; ER;
Experimental Bovine Spongiform Encephalopathy: Detection of PrPSc in the Small Intestine Relative to Exposure Dose and Age
Keywords: bovine spongiform encephalopathy; immunohistochemistry; PrPSc; small intestine
Bovine macrophage degradation of scrapie and BSE PrPSc
Keywords: BSE; Bovine; Degradation; Macrophage; PrPSc
Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak
Keywords: Prion; Transmissible spongiform encephalopathies; Scrapie; Nor98; PrPSc; Co-infection; Sheep
PrPSc is associated with B cells in the blood of scrapie-infected sheep
Keywords: Prion; Scrapie; Blood; PrPSc; Immunoassay; B cells;
Enhanced prion protein stability coupled to DNA recognition and milieu acidification
Keywords: PrP; prion protein; PrPSc; prion scrapie; mrPrP; recombinant murine prion protein; PrPC; cellular prion protein; TSEs; transmissible spongiform encephalopathies; GdmCl; guanidinium chloride; NA; nucleic acid.; Prion; DNA; Stability; Unfolding; pH; Urea; G
The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro
Keywords: Transmissible spongiform encephalopathy; Prion; Prion protein; Conformational conversion; Glycophosphatidylinositol anchor; GPI; glycophosphatidylinositol; NBH; normal hamster brain homogenate; PI-PLC; phosphatidylinositol-specific phospholipase C; PK; pr