کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10758147 | 1050404 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of early transient accumulation of PrPSc in immune cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
PrPSc is known to elicit no specific immune response and the immune cells are suspected to support its accumulation. In the present study, we investigated the response of some immune cell types to PrPSc to characterize an observed early transient accumulation of PrPSc. After cells were treated with PrPSc-brain homogenate, PrPSc was transiently accumulated for the first 8-12Â h post-exposure then completely cleared by the 5th day of the experiment. The accumulated PrPSc was not a de novo product of the cell PrPC. Further investigation of this phenomenon revealed some potential factors influencing it. These factors included cholesterol homeostasis, temperature, the degradation power of the cell and the availability of sufficient PrPC. Our in vitro results suggest that immune cells, especially macrophages are potential risk factors for the accumulation and intercellular spread of PrPSc if the complete clearance of PrPSc were not fulfilled.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 3, 27 September 2013, Pages 340-345
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 3, 27 September 2013, Pages 340-345
نویسندگان
Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishiguro,