دانلود مقالات ISI درباره Sirt1 + ترجمه فارسی

Inhibitory effects of resveratrol on hypoxia-induced inflammation in 3T3-L1 adipocytes and macrophages

Keywords: C/EBP; CCAAT-enhancer-binding protein; FAS; fatty acid synthase; GLUT1; glucose transporter 1; HIF1; hypoxic inducible factor 1; HSD1; hydroxysteroid dehydrogenase 1; ICAM; intercellular cell adhesion molecule; IL6; interleukin 6; NFkB; nuclear factor kap

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

Keywords: Alzheimer's Disease; Amyloid-β; BACE-1; Leptin; NF-κB; SIRT1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes

Keywords: SIRT1; miR-34a; p53; Keratinocytes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Role of SIRT1 and AMPK in mesenchymal stem cells differentiation

Keywords: MSCs; mesenchymal stem cells; SIRT1; silent mating type information regulation 2 homolog 1; AMPK; AMP-activated protein kinase; ROS; reactive oxygen species; CR; calorie restriction; PPARγ; peroxisome proliferator-activated receptor gamma; C/EBP; CCAAT/e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol delays Wallerian degeneration in a NAD+ and DBC1 dependent manner

Keywords: Axonal degeneration; Wallerian degeneration; DBC1; SIRT1; Resveratrol;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation

Keywords: 12S; mitochondrial rRNA; AICAR; aminoimidazole-4-carboxamide riboside, an adenosine analogue stimulating AMPK; AMPK; catalytic α1/2-subunit of AMP dependent protein kinase; pAMPK; AMPK phosphorylated at serine 172 of the α-subunit; AU; arbitrary units;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Beneficial effect of resveratrol on bovine oocyte maturation and subsequent embryonic development after in vitro fertilization

Keywords: Antioxidant; bovine; oocyte maturation; resveratrol; SIRT1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

Keywords: Alcoholic Fatty Liver; Lipid Metabolism; Inflammation; Signal Transduction; AH; alcoholic hepatitis; ALD; alcoholic liver disease; mRNA; messenger RNA; NFATc4; nuclear factor of activated T cells c4; PGC; peroxisome proliferator-activated receptor co-fact

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2-HNF-1α-FXR Signaling and Alters Systemic Bile Acid Homeostasis

Keywords: Ileal Bile Acid Absorption; Bile Acid Synthesis; Liver Damage; Cholestasis; CA; cholic acid; DCoH2; dimerization cofactor of hepatocyte nuclear factor 1α 2; FGF15; fibroblast growth factor 15; FXR; farnesoid X receptor; HA; hemagglutinin; HNF-1α; hepato

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway

Keywords: ACC; acetyl-CoA carboxylase; ALA; alpha-lipoic acid; ALT; alanine aminotransferase; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated protein kinase; AST; aspartate aminostransferase; ATGL; adipose triacylglycerol lipase; CaMKK; Ca2+/cal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells

Keywords: ACO; acyl-CoA oxydase; AMPK; AMP-activated protein kinase; APRT; adenosyl phosphoribosyl transferase); ACC; acetyl-CoA carboxylase); ChREBP; carbohydrate response element binding protein; CYP4A1; cytochrome P450 4A1; FAS; fatty acid synthase; Foxa2; forkh

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway

Keywords: AIF; apoptosis inducing factor; AP-1; activating protein-1; AP-2; activating protein 2; BMP2; bone morphogenetic protein 2; cMSC; chorion-derived mesenchymal stem cells; CTRL; control cells; DIFF; differentiating cells; ECAR; extracellular acidification r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis

Keywords: VNR; vinorelbine; SIRT1; sirtuin 1; AMPK; AMP-activated protein kinase; PKC; protein kinase C; LKB1; protein liver kinase B1; TAK1; TGF-β-activated kinase-1; TAB1; TAK-binding protein-1; ROS; reactive oxygen species; DCF-AM; 2′,7′-dichlorofluorescein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice

Keywords: Troxerutin; NAD+; SirT1; Lipin 1; Hepatic lipid homeostasis; NAFLDTroxerutin (PubChem CID 9896814); EX527 (PubChem CID 5113032)

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

Keywords: ALDH2; Aging; Cardiac geometry; Contractile function; AMPK; Sirt1; Free radicals;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Alteration in Bioenergetic Regulators, SirT1 and Parp1 Expression Precedes Oxidative Stress in Rats Subjected to Transient Cerebral Focal Ischemia: Molecular and Histopathologic Evidences

Keywords: SirT1; Parp1; bioenergetics; oxidative stress; focal cerebral ischemia;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

Keywords: AMPK; AMP-activated protein kinase; CaMKs; calmodulin-dependent protein kinases; CPEO; chronic progressive external ophthalmoplegia; CREB; cAMP-responsive element-binding protein; FOXO; forkhead box O transcription factor; G6PD; glucose 6-phosphate dehydr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 metabolic actions: Integrating recent advances from mouse models

Keywords: SIRT1; Transgenic models; Energy homeostasis; Insulin resistance

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Sirtuins: guardians of mammalian healthspan

Keywords: aging; longevity; age-associated disease; NAD+; mitochondria; SIRT1; SIRT3; SIRT6

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

Keywords: Liver-Specific Disruption of Sirt1; Hepatocyte-Derived Hormone; Metabolic Homeostasis; Obesity; Ad; adenovirus; BAT; brown adipose tissue; CPT1α; carnitine palmitoyltransferase 1α; FAS; fatty acid synthase; FGF21; fibroblast growth factor 21; MCAD; medi

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model

Keywords: SIRT1; mesenchymal stem cells; aging; myocardial infarction; stem cell therapy;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Honeybees and cell lines as models of DNA methylation and aging in response to diet

Keywords: DNMT; DNA methyltransferase; TOR; target of rapamycin; IGF1/insulin; insulin-like growth factor 1/insulin; AMPK; AMP-dependent protein kinase; SIRT; sirtuin; 10-HDA; 10-hydroxydecanoic acid; PGC-1α; peroxisome proliferator-activated receptor gamma coacti

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

SIRT1 negatively regulates the protein stability of HIPK2

Keywords: SIRT1; HIPK2; Deacetylation; Ubiquitination; Proteasomal degradation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

Keywords: Parkinson's disease; Neuroinflammation; SIRT1; Microglia; PC12 cells; p53;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting DNA damage response: Threshold, chromatin landscape and beyond

Keywords: DSBs; double strand breaks; γ-H2AX; phosphorylation of histone variant H2AX in Ser139; SUMO; small ubiquitin modifier; ROS; reactive oxygen species; IR; ionizing radiation; Tip60; Tat-interactive 60; HAT; histone acetyltransferase; HDAC; histone deacetyl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1

Keywords: CBX8; chromodomain protein8; PcG; Polycomb protein; PRC1; polycomb repressive complexes1; GST; glutathione S-transferase; β-gal; β-galactosidase; GFP; green fluorescent protein; CBX8; SIRT1; p53; Senescence; Cancer; Epigenetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation

Keywords: β-TrCP; SIRT1; Post-translational degradation; Pyruvate; Resveratrol; Nucleus;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Resveratrol vs. calorie restriction: Data from rodents to humans

Keywords: Calorie restriction; Resveratrol; Energy metabolism; SIRT1; AMPK;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines

Keywords: Quinazoline; Indole; SIRT1; Cancer; Pd/C;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Keywords: HIV-1; human immunodeficiency virus type 1; LTR; long terminal repeats; PTM; post-translational modification; SIRT1; sirtuin 1; NAD+; nicotinamide adenine dinucleotide; NAMPT; nicotinamide phosphoribosyltransferase; DMEM; Dulbecco's modified Eagle's mediu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of cardiac and renal ischemia-reperfusion injury by microRNAs

Keywords: MicroRNAs; Ischemia-reperfusion injury; Kidney; Heart; Free radicals; CaMKII; calmodulin kinase II; DRP1; dynamin-related protein-1; EPC; endothelial progenitor cell; FGFR2; fibroblast growth factor receptor 2; Hsp20; heat shock protein 20; HIF-1α; hyp

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticlemiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

Keywords: Apoptosis; miRNAs; NAFLD; p53; SIRT1; UDCA; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; miRNA or miR; microRNA; SIRT1; Sirtuin 1; UDCA; ursodeoxycholic acid; CA; cholic acid; FFAs; free fatty acids; JNK; c-Jun N-terminal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation

Keywords: Calorie restriction; AMPK; SIRT1; Mitochondrial biogenesis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells

Keywords: Adipokine; Omentin-1; HCC cells; p53; Acetylation; Sirt1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes

Keywords: SIRT1; Adipose tissue; Visceral obesity; Insulin resistance; Adiponectin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Involvement of SIRT1-AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet

Keywords: I3C; indole-3-carbinol; HFD; high-fat diet; ND; normal diet; SREBP-1c; sterol regulatory element-binding protein-1c; FAS; fatty acid synthase; LPL; lipoprotein lipase; SIRT1; silent mating type information regulation 2 homolog 1; AMPK; AMP-activated prote

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Scientific evidence for traditional claim of anti-obesity activity of Tecomella undulata bark

Keywords: ANOVA; analysis of variance; C/EBPα; CCAAT/enhancer binding protein alpha; DMEM; Dulbecco's modified eagle medium; DMSO; dimethyl sulfoxide; EATUB; ethyl acetate extract of Tecomella undulata bark; E2F1; transcription factor; FBS; fetal bovine serum; FCS

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleAdipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity

Keywords: SIRT1; SIRT3; SIRT6; NAFLD; Insulin resistance; Metabolism;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells

Keywords: RPE; retinal pigment epithelial; PI3K; phosphatidylinositol-3-kinase; AZA; 5-aza-2′-deoxycytidine; ROS; reactive oxygen species; MAP kinases; mitogen-activated protein (MAP) kinases; Ultraviolet B; SIRT1; AKT; Resveratrol; RPE;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging

Keywords: SIRT1; Endothelial dysfunction; NADPH oxidase; PPARα;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice

Keywords: SalA; salvianolic acid A; ConA; concanavalin A; ALT; alanine aminotransferase; AST; aspartate aminotransferase; TNF-α; tumor necrosis factor-α; IFN-γ; interferon gamma; SIRT1; sirtuin1; Bcl-xL; B-cell lymphoma-extra large; NF-κB; nuclear factor κB; A

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes

Keywords: Resistin; SIRT1; Hepatocytes; PPARα; PGC-1α; Senescence-associated β-galactosidase activity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro

Keywords: Poly(ADP-ribose) polymerase-1; PARP-1; Hippocampal neuronal culture; HNC; Acquired epilepsy; AE; Nicotinamide adenine dinucleotide; NAD; Apoptosis-inducing factor; AIF; Poly(ADP-ribose); PAR; Mitochondrial permeability transition; MPT; Terminal deoxynucle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The role of SIRT1 in ocular aging

Keywords: review; SIRT1; eye;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury

Keywords: SIRT1; sirtuin 1; PGC-1α; peroxisome proliferator activated receptor γ coactivator-1α; ATPβ; ATP synthase subunit β; COX I; cytochrome c oxidase subunit I; NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8; Drp1; dynamin related protein 1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation

Keywords: Atherosclerosis; Wall shear stress; Poly(ADP-ribose) polymerase 1; Sirt1; Inflammatory factor; NF-κB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; CRP; C-reactive protein; HP; haptoglobin; IKK; IkappaB kinase; IL-6; Interleukin-6; IL6Rα; IL-6 receptor subun

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Redox-regulating sirtuins in aging, caloric restriction, and exercise

Keywords: 8-oxoG, 8-oxo-7; 8-dihydroguanine; APE1; apurinic/apyrimidinic endonuclease 1; BER; DNA base excision repair; CR; caloric restriction; DSB; DNA double-strand break; FOXO; forkhead homeobox type O protein; eIF2α; eukaryotic initiation factor 2α; eNOS; en

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

Keywords: Sirt1; Autophagy; PrP(106-126); Neurotoxicity; Mitochondrial dysfunction;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه