دانلود مقالات ISI درباره Sirt1 + ترجمه فارسی

Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway

Keywords: Diabetic retinopathy; Cocoa; GFAP; SIRT1; NF-kB; NAD+; Neurodegeneration

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Troxerutin protects against 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion

Keywords: Polybrominated diphenyl ethers; Oxidative stress; NAD+; Inflammation; Troxerutin; AC-H3K9; acetyl-histone H3 (Lys9); AC-p65 (K310); acetyl-NF-κB p65 (Lys310); ALT; alanine aminotransferase; BDE-47; 2,2′,4,4′-tetrabromodiphenyl ether; CYP; cytochrome

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes

Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; ATGL; adipose triglyceride lipase; CaMKK; calcium/calmodulin-dependent protein kinase kinase; FAS; fatty acid synthase; FFA; free fatty acid; HFD; high fat diet; Hon; honokiol; LKB1; liver k

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Novel splice isoforms of dairy goat DBC1 and their diverse mRNA expression profiles

Keywords: DBC1; deleted in breast cancer 1; DBC1a; deleted in breast cancer 1a; SIRT1; sirtuin 1; ERα; estrogen receptors α; ERβ; estrogen receptors β; NAD+; nicotinamide adenine dinucleotide; RT-PCR; reverse transcript polymerase chain reaction; qRT-PCR; quant

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights

Keywords: AK; acetyllysine; AP-1; activator protein 1; AR; aldose reductase; BGT1; betaine/gamma-aminobutyric acid transporter; Egr-1; early growth response protein 1; FSP27; fat-specific protein 27; HSP90; heat shock protein 90; NAD+; nicotinamide adenine dinucleo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuin regulation in aging and injury

Keywords: SIRT1; Mitochondria; Ischemia/reperfusion; Hypoxia;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge

Keywords: Sirtuin 1 (SIRT1); skin barrier; filaggrin; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; ARNT; Aryl hydrocarbon receptor nuclear translocator; BaP; Benzo(a)pyrene; cHet; Epidermis-specific heterozygous SIRT1 deletion; cKO; Epidermis-specific hom

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Keywords: Aβ; amyloid β protein; AMPK; adenosine monophosphate activated protein kinase; CGNs; cerebellar granule neurons; ETC; electron transport chain; H2O2; hydrogen peroxide; HO-1; heme oxygenase-1; LXR; liver X receptor; MAPK; mitogen-activated protein kinas

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Keywords: SIRT1; Energy homeostasis; Insulin resistance; Brown adipose tissue

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Keywords: Obesity; SIRT1; PPAR03B3; Glucose homeostasis; Insulin resistance; Phosphorylation

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells

Keywords: Human cardiac progenitor cells; Doxorubicin-induced cardiomyopathy; SIRT1; Resveratrol;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD

Keywords: AD; Alzheimer's disease; CV; Cresyl Violet; DG; dentate gyrus; EC; entorhinal cortex; FC; frontal cortex; ML; molecular layer; NBF; neutral buffered formalin; PaS; parasubiculum; PFC; prefrontal cortex; PP; perforant path; PrS; presubiculum; RAM; radial

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications

Keywords: Short chain fatty acids; SIRT1; EZH2; P-TEFb; HIV-1 transactivation;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients

Keywords: Alzheimer disease; Biomarkers; Brain derived neurotrophic factor; DNA methylation; Presenilin 1; Sirtuin 1; AD; Alzheimer's disease; APP; amyloid precursor protein; CpG; cytosine-guanine; MMSE; Mini-Mental State Examination; MCI; mild cognitive impairme

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease

Keywords: Graves' disease (GD); Histone modifications; Histone acetylation; Peripheral blood mononuclear cells (PBMCs); AS; ankylosing spondylitis; CD40; Cluster of Differentiation 40; CTLA4; CTLcytotoxic T lymphocyte-associated antigen-4; CREBBP; CREB binding prot

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1

Keywords: Hypertension; Insulin resistance; miR-543; SIRT1;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2015 سفارش ترجمه

Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway

Keywords: Nicotinic acid; SIRT1; Inflammation; Cluster of differentiation 40; Endothelium;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2015 سفارش ترجمه

The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy

Keywords: Morbid obesity; SNPs; FTO; MC4R; SIRT1; metabolic syndrome

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The function of nicotinamide phosphoribosyltransferase in the heart

Keywords: Heart; Ischemia; Reperfusion; NAD+; Sirt1; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions

Keywords: AMP protein kinase (AMPK); Calorie restriction; Glucose; Insulin; SIRT1; PGC-1α

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord

Keywords: SIRT1; Morphine tolerance; Resveratrol; Ac-H3; Rat; Spinal cord;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway

Keywords: Angiotensin II; Osteoblasts; Mitochondrial oxidative stress; mtDNA damage; MnSOD; SIRT1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

AROS has a context-dependent effect on SIRT1

Keywords: AROS; p53; Protein-protein interaction; SIRT1; Sirtuin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i

Keywords: miRNA, microRNA; SIRT1, sirtuin 1, NAD-dependent deacetylase sirtuin-1; UTR, untranslated region; TLR, Toll-like receptorlet-7; SIRT1; C. parvum; Epithelium; NF-κB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases

Keywords: inflammation; metabolic diseases; PARP-1; PARP-2; SIRT1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells

Keywords: Obesity; Colon cancer; Hyperinsulinemia; Docosahexaenoic acid; SIRT1; Cyclooxygenase-2; Sterol regulatory element-binding protein 1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols

Keywords: SIRT1; SIRT2; Ginkgolic acid; Urushiol; Cytotoxicity; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Sesamin ameliorates doxorubicin-induced cardiotoxicity: Involvement of Sirt1 and Mn-SOD pathway

Keywords: Ses; sesamin; DOX; doxorubicin; Mn-SOD; Manganese SOD; Sirt1; Sirtuin 1; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ROS; reactive oxygen species; MDA; malondialdehyde; Doxorubicin; Sesamin; Mn-SOD; Sirt1; Cardiotoxicity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Keywords: SIRT1; 3-(Furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives; Inhibitor; Structure-activity relationship; Protein-ligand interaction; Deacetylation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation

Keywords: SIRT1; Melanoma; p53; p21; Tenovin-1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPARγ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes

Keywords: 2BrPhF; 2-(2-bromophenyl)-formononetin; C7F; 2-heptyl-formononetin; AICAR; 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide; AMPK; AMP-activated protein kinase; PPAR; peroxisome proliferator-activated receptor; Sirt1; sirtuin 1; Adipocytes; Isoflavone

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss

Keywords: SIRT1; Cochlea; Auditory cortex; C57BL/6; Presbycusis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Mussel oligopeptides protect human fibroblasts from hydrogen peroxide (H2O2)-induced premature senescence

Keywords: CK; control experiment; DMSO; dimethylsulfoxide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; NAMPT; nicotinamide phosphoribosyltransferase; Prx1; peroxiredoxin 1; PSC; premature senescence control; SA-β-gal; senescence-associated

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary

Keywords: SIRT1; Follicular granulosa cell; Apoptosis; Porcine; Ovary;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Reversible acetylation of Lin28 mediated by PCAF and SIRT1

Keywords: Lin28; PCAF; SIRT1; Acetylation; Protein stability;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model

Keywords: AMPK; AMP-activated protein kinase; Cr; creatinine; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HO-1; heme oxygenase 1; IL; interleukin; iNOS; inducible nitric oxide synthase; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor κB; Nrf2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway

Keywords: miR-217; SIRT1; EMT; Chronic pancreatitis; Pancreatic cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Identification, stability and expression of Sirt1 antisense long non-coding RNA

Keywords: lncRNA; long noncoding RNA; Sirt1; Sirtuin 1; NATs; natural antisense transcripts; RBPs; RNA-binding proteins; miRNAs; microRNA; HuR; human antigen R; AS; antisense transcripts; UCH1; Ubiquitin Carboxyl-Terminal Esterase L1; Ptprj; Protein Tyrosine Phosph

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1

Keywords: Alpha-lipoic acid (PubChem CID: 864); ALA; Cardiac hypertrophy; PARP-2; SIRT1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

P53 and Sirt1: Routes of metabolism and genome stability

Keywords: p53; SIRT1; Metabolism; Tumor suppression; Genome integrity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes

Keywords: MicroRNA; SIRT1; p53; Keratinocytes

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3

Keywords: Keratinocytes; Aquaporin 3; Resveratrol; ERK; ARNT; SIRT1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 and other sirtuins in metabolism

Keywords: sirtuins; SIRT1; calorie restriction; aging; metabolism; CR mimetics; NAD+

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100β secretion by regulating sirtuin 1 in C6 rat glioma cells

Keywords: Polyphenols; S100β; SIRT1; Oxidative stress

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Quantitative insights for the design of substrate-based SIRT1 inhibitors

Keywords: QSAR; CoMFA; Sirtuin; SIRT1; Inhibitor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of p53 by spermine mediates induction of autophagy in HT1080 cells

Keywords: Spermine; Acetyl-p53; Autopagy; HAT; SIRT1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleCardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation

Keywords: CT-1; Cardiotrophin-1; rCT-1; recombinant CT-1; NAFLD; non-alcoholic fatty liver disease; HFD; high fat diet; FA; fatty acid; ER; endoplasmic reticulum; DN; dominant negative; AMPK; AMP-activated protein kinase; SIRT1; sirtuin1; TG; triacylglycerol; NASH;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway

Keywords: Paeonol (PubChem CID: 11092)Aging; Traditional Chinese medicine; Paeonol; Oxidative stress; Endothelial cells; Sirt1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

Keywords: Alzheimer's disease; Voluntary exercise; GABA and NMDA receptors; Synaptic proteins; GDNF; SIRT1; 3xTg-AD mouseAD, Alzheimer's disease; APP, amyloid precursor protein; BPSD, Behavioral and Neuropsychiatric Symptoms of Dementia; ANOVA, analysis of variance

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis

Keywords: Food intake; Hormones; Insulin; Obesity; SIRT1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه