Keywords: Stem cells; Regeneration; Neuroprotection; Cell-based therapy; Clinical trials; AMSCs; adipose-derived MSCs; ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; BMSC; bone marrow MSC; CNS; central nervous system; CST; corticospina
مقالات ISI (ترجمه نشده)
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Keywords: ALS; amyotrophic lateral sclerosis; ASC; adipose-derived mesenchymal stem cells; BDNF; brain-derived growth factor; bFGF; basic fibroblast growth factor; BM-MSC; derived from bone marrow; CCT; central conduction time; ChAT; coline acetyltransferase; cMAP;
Keywords: ALS; amyotrophic lateral sclerosis; ANOVA; analysis of variance; CGRP; calcitonin gene-related peptide; FL; full-length; GFAP; glial fibrillary acidic protein; GSK-3β; glycogen synthase kinase-3β; Iba1; ionized calcium-binding adaptor molecule 1; Li; li
IGF1 affects macrophage invasion and activation and TNF-α production in the sciatic nerves of female SOD1G93A mice
Keywords: ALS; amyotrophic lateral sclerosis; IGF1; insulin-like growth factor 1; SOD1; Cu2+/Zn2+ superoxide dismutase; TNF-α; tumor necrosis factor alpha; AAV; adeno-associated virus; Amyotrophic lateral sclerosis; Sciatic nerve; Macrophage; Tumor necrosis factor
Biological and anticancer properties of Inonotus obliquus extracts
Keywords: ABTS; 2,2â²-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid; CAT; catalase; DMSO; dimethyl sulfoxide; DPPH; 2,2-diphenyl-1-picrylhydrazyl; FBS; fetal bovine serum; GSHPx; glutathione peroxidase; H2DCFDA; 2',7'-dichlorodihydrofluorescein diacetate; I
Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells
Keywords: PA; palmitic acid; NEFA; non-esterified fatty acid; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; shRNA; short hairpin RNA; CCK8; cell counting assay kit-8; Pdx-1; pancreatic and duodenal homeobox factor 1; MafA; V-maf musculoaponeuro
Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio)
Keywords: Nrf2; nuclear factor, erythroid 2-like 2; omp; olfactory marker protein b; dpf; days post fertilization; EM; E3 embryo medium; SRP; Superfund Research Program; Zn; zinc; As; arsenic; Cr; chromium; Cd; cadmium; TCA; taurocholic acid; OE; olfactory epitheli
Oral administration of palatinose vs sucrose improves hyperglycemia in normal C57BL/6J mice
Keywords: Palatinose; Hepatic lipogenesis; Cholesterol homeostasis; C57BL/6J mice; Sucrose; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AST; serum aspartate aminotransferase; AUC; area under the curve; CYP7A1; cholesterol 7 alpha-hydroxylase; FAS; f
Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
Keywords: Akt; Protein kinase B; AP-1; Activator protein-1; ASK1; Apoptosis signal-regulating kinase 1; ATF2; activating transcription factor 2;; ChIP; Chromatin immunoprecipitation;; DEN; Diethyl nitrosamine;; EGFR; Epidermal growth factor receptor; G6PDH; Glucose
Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro
Keywords: LCE; Lespedeza cuneata ethanol extract; BPA; bisphenol A; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; PARP; Poly (ADP-ribose) polymerase; hs-CRP; high-sensitivity C-reactive protein; GOT; glutamic oxaloacetic transaminase; GPT; glutamic pyr
N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes
Keywords: ACD; citrate-dextrose solution; APC; activated protein C; ATIII; antithrombin III; FITC; fluorescein isothiocyanate; Glo; glyoxalase; GPx-1; glutathione peroxidase-1; GSH; glutathione; GSSG; glutathione disulfide; MG; methylglyoxal; NAC; N-acetylcysteine;
Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; Withania somnifera; SOD1; Autophagy;
TLQP Peptides in Amyotrophic Lateral Sclerosis: Possible Blood Biomarkers with a Neuroprotective Role
Keywords: ALS; Amyotrophic Lateral Sclerosis; ALSFRS-R; ALS Functional Rating Scale-Revised; C3AR; complement component 3a receptor 1; gC1q-R; receptor for the globular heads of c1q; DMEM; Dulbecco's modified Eagle's medium; EDTA; ethylenediaminetetraacetic aci
The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord
Keywords: ALS; amyotrophic lateral sclerosis; CD11b; a CD antigen that contains a conserved domain and serves as a marker of microglia; GFAP; glial fibrillary acidic protein; GLAST; glutamate aspartate transporter; GLT-1; glutamate transporter 1; GR; glucocorticoid
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression
Keywords: ALS; amyotrophic lateral sclerosis; ChAT; choline acetyltransferase; FTD; frontotemporal dementia; IGF-II; insulin-like growth factor II; IGF-IIR; IGF-II/cation-independent mannose-6-phosphate receptor; IGF-IR; IGF-I receptor; isl-1/2; islet 1 and 2; iPSC
Evaluation of biomarkers in Mytilus galloprovincialis as an integrated measure of biofilm-membrane bioreactor (BF-MBR) system efficiency in mitigating the impact of oily wastewater discharge to marine environment: a microcosm approach
Keywords: CAT; Catalase; CYP4Y1; Cytochrome P450; HSP70; Heat Shock Protein 70; MT10; Metallothionein 10; SOD1; Superoxide dismutase 1; Laboratory-scale systems; Quantitative PCR; TEM; Pollution prevention; Biotechnological strategy;
Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress
Keywords: α-F1 and β-F1; Alpha and beta subunits of the ATP synthase; ACO1; Aconitase 1; CORE II; Ubiquinol-cytochrome c reductase complex; CPT1; Carnitine palmitoyltransferase I; CS; Citrate synthase; ENO 1; Enolase 1; G6PDH; Glucose-6-phosphate dehydrogenase; G
Silver nanoparticle fate in mammals: Bridging in vitro and in vivo studies
Keywords: 3MPS; 3-mercapto-1-propanesulfonate; AF4; asymmetrical flow field-flow fractionation; AgNM; silver nanomaterial; AgNP; silver nanoparticle; Ag2S; silver sulfide; BSA; bovine serum albumin; CRM; confocal reflectance microscopy; CSE; cystathionine γ-lyase;
Deciphering the loss of metal binding due to mutation D83G of human SOD1 protein causing FALS disease
Keywords: FALS; SOD1; Zn-binding; DMD;
Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes
Keywords: Amyotrophic Lateral Sclerosis; SOD1; TDP43; FUS; histone posttranslational modifications; DNA methylation;
The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1
Keywords: Amyotrophic lateral sclerosis (ALS); Motor neurone disease; Neurodegeneration; Mouse model; Superoxide dismutase 1 (SOD1); Ceruloplasmin; Cytochrome c oxidase (CCO); Copper transporter 1 (CTR1); Copper; Diacetyl-bis(4-methylthiosemicarbazonato)copperII [C
Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury
Keywords: Akr1a; aldehyde reductase; ALT; alanine transaminase; AsA; ascorbic acid; CHOP; CCAAT-enhancer-binding protein homologous protein; CYP; cytochrome P450; ER; endoplasmic reticulum; H&E; hematoxylin and eosin; i.p.; intraperitoneally; JNK; c-Jun N-terminal
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses
Keywords: ALS; amyotrophic lateral sclerosis; BMDM; bone marrow-derived macrophages; C9orf72; chromosome 9 open-reading frame 72; CNS; central nervous system; CXCL; CXC chemokine ligand; DAMPs; damage-associated molecular patterns; DMEM; Dulbecco's Modified Eagle
Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice
Keywords: ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; CA1; Cornu Ammonis 1; CA2; Cornu Ammonis 2; CA3; Cornu Ammonis 3; DG; dentate gyrus; fEPSP; field excitatory postsynaptic potentials; FTD; fronto-temporal dementia; HFS; high fre
The multi-dimensional roles of astrocytes in ALS
Keywords: Astrocyte; Neuroinflammation; ALS; TDP-43; SOD1;
Dynamic regulation of six histone H3 lysine (K) methyltransferases in response to prolonged anoxia exposure in a freshwater turtle
Keywords: K; lysine; R; arginine; H3K4me1; monomethylated histone H3 lysine 4; H3K27me1; monomethylated histone H3 lysine 27; H3K9me3; trimethylated histone H3 lysine 9; HP1; heterochromatin protein 1; HKMT; histone lysine methyltransferases; SAM; S-adenosyl-L-meth
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
Keywords: ALP; alkaline phosphatase; Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1; Bmi-1â/â; Bmi1 deficiency; Bmi-1+/â; Bmi-1 heterozygous; Col-I; type I collagen; Col-II; type II collagen; FOXO; Forkhead box O; GPX1; Glutathione pe
Frequency of C9orf72 hexanucleotide repeat expansion and SOD1 mutations in Portuguese patients with amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; C9orf72 hexanucleotide repeat expansion; SOD1; Mutation; Phenotype; Frontotemporal dementia;
Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function
Keywords: AOPPs; advanced oxidation protein products; CI; cell index; DCFH-DA; 2â²,7â²-Dichlorofluorescin diacetate; DHE; dihydroethidium; DAB; 3,3â²-diaminobenzidine-tetrahydrochloride-dihydrate; DRG; dorsal root ganglion; GCLC; glutamate-cysteine ligase cataly
Mitochondria as pharmacological targets in Down syndrome
Keywords: AD; Alzheimer's disease; AGO; Argonaute proteins; AMPK; AMP-activated protein kinase; ANTs; adenine nucleotide translocators; AK; adenylate kinase; APP; amyloid-β precursor protein; ASD; autism spectrum disorder; CAT; catalase; CNS; central nervous syste
Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS
Keywords: ALS; P188; F68; Poloxamer; Protein misfolding; Superoxide dismutase; SOD1; G93A; Atomic force microscopy; AFM; Electrophysiology; Membrane toxicity; Lipid peroxidation;
Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-κB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1G93A mutation
Keywords: ALS; Amyotrophic lateral sclerosis; AEG-1; Astrocyte elevated gene-1; ACM; astrocyte-conditioned medium; CBP; CREB-binding protein; COX-2; Cyclooxygenase-2; DMSO; dimethyl sulfoxide; DL-NBP; DL-3-n-butylphthalide; DMEM; Dulbecco modified Eagle medium; EAA
ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes
Keywords: ALS; Amyotrophic lateral sclerosis; Drp1; dynamin-related protein 1; G93A; an ALS mouse model with overexpression of ALS-associated mutation SOD1G93A; GFP; green fluorescence protein; OPA1; optic atrophy protein 1; SOD1; superoxide dismutase 1; SOD1G93A;
The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea
Keywords: Antioxidant therapy; Gpx1; Il1b; Il4; PCR-arrays; Sod1; ABR; Auditory Brainstem Responses; AGs; Aminoglycosides; COX-2; cyclooxygenase 2; DE; Differentially expressed; FC; Fold change; IHC; Inner hair cells; IP; intraperitoneal; IPL; Interpeak latency; NA
From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives
Keywords: 2-VO; 2 vessel occlusion; Aβ; amyloid-β protein; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; Br-NBP; 3-butyl-6-bromo-1(3âH)-isobenzofuranone; BZP; sodium(±)-5-bromo-2-(a-hydroxypentyl) benzoate; CFDA
Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis
Keywords: Motor neuron disease; Dendrite; Spine density; SOD1; TDP-43;
Exploring the multifaceted roles of heat shock protein B8 (HSPB8) in diseases
Keywords: Aβ; amyloid β-peptide; ACD; α-crystallin domain; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; AR; androgen receptor; BAG3; BCL2 associated athanogene 3; BMP; bone morphogenetic protein; CASA; chaperone-assisted selective autophagy; CHIP;
Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner
Keywords: 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul
Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD
Keywords: P2X7 receptor; Sod1; AMD; Retinal pigmented epithelium (RPE); Oxidative stress; Microparticle (MP);
Redox regulation of proteasome function
Keywords: Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
Probing the inhibitory activity of epigallocatechin-gallate on toxic aggregates of mutant (L84F) SOD1 protein through geometry based sampling and steered molecular dynamics
Keywords: EGCG; SOD1; L84F; Docking; Conformational sampling;
Regression model for predicting pathogenic properties of SOD1 mutants based on the analysis of conformational stability and conservation of hydrogen bonds
Keywords: ALS; amyotrophic lateral sclerosis; EN; elastic-network models; MD; molecular-dynamics simulations; PDB; protein data bank; WT; wild-type; ALS; SOD1; Elastic network models; Hydrogen bonds; Protein stability; Regression model; Patient survival time;
Silencing strategies for therapy of SOD1-mediated ALS
Keywords: Therapy; RNAi; SOD1; ALS;
Research PaperMutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
Keywords: Excitotoxicity; Glutamate; Astrocyte; Amyotrophic lateral sclerosis; EAAT2; GLT-1; SOD1;
An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1)
Keywords: SOD1; Amyotrophic lateral sclerosis (ALS); Aggregation; Oligomers; Amyloid; Enzyme activity;
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4
Keywords: miR-145; Granulosa cell; Oxidative stress; Apoptosis; KLF4; GCs; granulosa cells; ROS; reactive oxygen species; SOD1; superoxide dismutase 1; H2O2; hydrogen peroxide; KLF; Krüppel-like factor; LH; luteinizing hormone; IGF1; insulin-like growth factor 1;
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
Keywords: ALS; amyotrophic lateral sclerosis; PGC-1α; peroxisome-proliferator activated receptor gamma coactivator)-1α; SOD1; superoxide dismutase 1; SOD3; superoxide dismutase 3; FUS/TLS; fused in sarcoma/translocated in sarcoma; Amyotrophic lateral sclerosis; L
The identification of a novel isoform of EphA4 and ITS expression in SOD1G93A mice
Keywords: ALS; amyotrophic lateral sclerosis; BCA; bicinchoninic acid; CHO; Chinese hamster ovary; DAPI; 4â²,6-diamidino-2-phenylindole; EphA; ephrin type-A receptor; EphA4-FL; full-length EphA4; EphB; ephrin type-B receptor; ESTs; expressed sequence tag sequences
Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
Keywords: AMD; Age Related Macular Degeneration; ANOVA; Analysis of Variance; ARBP; 60S Acidic Ribosomal Protein P0; BEST1; Bestrophin; CAT; Catalase; cDNA; Complementary DNA; CMST; Cell Mito Stress Test; CRABP; Cellular Retinoic Acid Binding Protein; CRALBP; Cellu