Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI)
Keywords: TGF; TGF-beta; TGFβ; ALK; TGFBR;
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Halofuginone attenuates intervertebral discs degeneration by suppressing collagen I production and inactivating TGFβ and NF-кB pathway
Keywords: IVD; intervertebral discs; ECM; extracellular matrix; TGFβ; transform growth factor-β; NF-κB; nuclear factor of kappa b; IL-1β; interleukin 1β; IL-6; interleukin 6; IL-8; interleukin 8; NP; nucleus pulpous; AF; annulus fibrosus; CEPs; cartilaginous e
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption
Keywords: Cholesterol metabolism; Lipoproteins; Liver; Transcription; Dyslipidemia; ABCA1; ATP-binding cassette transporter A1; ACAT2; acyl-Coenzyme A:cholesterol acyltransferase 2; apo; apolipoprotein; CYP7A1; cholesterol 7α-hydroxylase; HMGCR; 3-hydroxy-3-methyl
LTBPs in biology and medicine: LTBP diseases
Keywords: AAA; Abdominal Aneurysm; RGD; arginylglycylaspartic acid; 8-Cys; eight cysteine; EMT; endothelial-mesenchymal transformation; ECM; extracellular matrix; ES; embryonic stem; FGF; fibroblast growth factor; LLC; large latent complex; LTBP; latent TGFβ bindi
Interaction of cancer cell-derived Foxp3 and tumor microenvironment in human tongue squamous cell carcinoma
Keywords: Cancer cell-derived Foxp3; Regulatory T cells; Tumor microenvironment; TGFβ;
Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis
Keywords: Anti-PD-L1; TGFβ; Immunogenic modulation; CTL-mediated lysis; Antibody-dependent cellular cytotoxicity; Bladder cancer;
Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression
Keywords: CSCC; cutaneous squamous cell carcinoma; PDX; patient-derived xenograft; RDEB; recessive dystrophic epidermolysis bullosa; SCC; squamous cell carcinoma; TGFβ; transforming growth factor-beta; VAF; variant allele frequency;
Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets
Keywords: Osteoarthritis; TGFβ; Chondrocyte hypertrophy; Microarray;
The von Hippel Lindau tumour suppressor gene is a novel target of E2F4-mediated transcriptional repression in preeclampsia
Keywords: ACOG; The American College of Obstetricians and Gynecologists; ASAH1; Acid Ceramidase enzyme; ccRCC; clear cell Renal Cell Carcinoma; CpG; Cytosine-phospho-Guanine; E2F4; E2 Transcription Factor 4; E-PE; Early-onset Preeclampsia; HIF1A; Hypoxia Inducible
Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression
Keywords: CxPA; carcinoma ex PA; GEMM; genetically engineered mouse model; HNSCC; head and neck squamous cell carcinomas; IF; immunofluorescence; K5; keratin 5; PI3K; phosphatidylinositol 3-kinase; SACC; salivary adenoid cystic carcinoma; SDC; salivary ductal carci
New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts
Keywords: αSMA; alpha smooth muscle actin; BMP; bone morphogenetic protein; COMP; cartilage oligomeric matrix protein; DDR; discoidin-domain receptor; ECM; extracellular matrix; FACIT; fibril-associated collagen with interrupted triple helices; HSP47; heat shock p
Dysregulation of fibrosis related genes in HCV induced liver disease
Keywords: Alb; Albumin; ALK PH; Alkaline phosphatase; ALT; Alanine amino transferase; APO; Apolipoprotein; AST; Aspartate transaminase; AUC; Area Under Curve; BIL.D; Direct bilirubin; BIL T; Total bilirubin; BMI; Body mass index; cDNA; Complementary DNA; CTGF; Conn
Increase in hyaluronic acid degradation decreases the expression of estrogen receptor alpha in MCF7 breast cancer cell line
Keywords: Estrogen signaling; Hyaluronic acid; Hyaluronidase; Breast cancer; Hormonal therapy resistance; CD44; cluster of differentiation 44; CV; crystal violet; E2; 17β-estradiol; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; ER; estrogen re
The TGFβ-induced lncRNA TBILA promotes non-small cell lung cancer progression in vitro and in vivo via cis-regulating HGAL and activating S100A7/JAB1 signaling
Keywords: TBILA; TGFβ; NSCLC; lncRNA; Metastasis;
Contribution of metabolic disease to bone fragility in MAGP1-deficient mice
Keywords: ECM; extracellular matrix; MAT; marrow adipose tissue; MAGP1; microfibril-associated glycoprotein-1; TGFβ; transforming growth factor beta; Fbn; fibrillin; Prx1; paired related homeobox-1; MAGP1; Bone; Skeletal fragility; Bone fracture; Diabetes; Obesity
Mechanisms controlling the anti-neoplastic functions of FoxO proteins
Keywords: ATM; ataxia telangiectasia mutated; cHL; classical hodgkin lymphoma; CML; chronic myelogenous leukemia; CSC; cancer stem cell; ERK; the extracellular signal-regulated kinase; ERα; the nuclear receptor estrogen receptor α; FoxO; forkhead box O; G6PC; glu
Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal
Keywords: ADCC; antibody dependent cell cytotoxicity; CD; cluster of differentiation; mAb; monoclonal antibody; CsA; cyclosporine; CTLA-4; T-lymphocyte antigen 4; GITR; glucocorticoid-induced tumor necrosis factor receptor (TNFR) family related gene; CCR4; C-C chem
NF-κB pathways in the development and progression of colorectal cancer
Keywords: 5-FU; 5-fluorouracil; AMPK/mTOR; AMP-activated Protein Kinase/mammalian target of rapamycin; APC; adenomatous polyposis coli; BAFF; B-cell activating factor; COX-2; cyclooxygenase 2; CRC; Colorectal cancer; DD; Dimerization domain; EGFR; epidermal growth
Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH
Keywords: aquaporin-2; cell cycle; cortical collecting duct; TGFβ; transcriptome;
Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFβ signaling and cell stemness
Keywords: Cardiomyopathy; Fibrillin; Marfan syndrome; Mechanotransduction; Osteopenia; Stem cell niche; TGFβ; Thoracic aortic aneurysm; AngII; Angiotensin II; AT1r; AngII type I receptor; BMD; Bone mineral density; DCM; Dilated cardiomyopathy; ECM; Extracellular m
KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast cancer
Keywords: Triple negative breast cancer; TGFβ; KiSS1; Cancer cell invasion; MMP9; Lymph node positive; p234 kisspeptin antagonist;
The role of TGFβ in wound healing pathologies
Keywords: ECM; extracellular matrix; DEB; dystrophic epidermolysis bullosa; DEJZ; dermo-epidermal junction zone; LH3; lysyl hydroxylase 3; TGFβ; transforming growth factor beta; Recessive dystrophic epidermolysis bullosa; Cell adhesion; Collagen VII; Fibrosis;
Is heterotopic ossification getting nervous?: The role of the peripheral nervous system in heterotopic ossification
Keywords: HO; heterotopic ossification; BMP; bone morphogenetic protein; BNB; blood-nerve barrier; TRPV1; transient receptor potential cation channel subfamily V member 1; sP; substance P; CGRP; Calcitonin gene-related protein; DRG; dorsal root ganglion; BBB; blood
Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling
Keywords: Cherubism; Stromal cell; Osteoblast; Osteoclast; Bone; TGFβ;
Expression Undercurrents of Sonic Hedgehog in Colorectal and Pancreatic Cancers
Keywords: Colorectal cancer; CRC; Pancreatic cancer; PC; Sonic hedgehog; SHH; Indian hedgehog; IHH; Desert hedgehog; DHH; Bone morphogenetic protein; BMP; Transforming growth factor; TGFβ; Pancreatic intra epithelial lesions; PanIN; Pancreatic ductal adenocarcinom
cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation
Keywords: α-SMA; alpha smooth muscle actin; cGKI; cGMP-dependent protein kinase I; cGKI-SM; cGKI-smooth muscle rescue mice; ECM; extracellular matrix; HSC; hepatic stellate cell; IPA; Ingenuity Pathway Analysis; MMP; matrix metallopeptidase; NAFLD; non-alcoholic f
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
Keywords: Akt; protein kinase B; CTGF; connective tissue growth factor; DMF; dimethyl fumarate; EDN1; endothelin 1; GSK-3; glycogen kinase 3; HC; healthy control; MMP; matrix metalloproteinase; NRF2; nuclear factor (erythroid-derived 2)-like 2; PAAm; polyacrylamide
The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis
Keywords: SSc; Systemic Sclerosis; ILD; Interstitial Lung Disease; ECM; Extracellular Matrix; MHC; Major Histocompatibility Complex; ATP; Adenosine Triphosphate; TGFβ; transforming growth factor β; SCFFBXL2; Skp-Cullin-F box (SCF) FBXL2; RNF216; RING Finger Prote
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
Keywords: Farnesoid X receptor; TGR5; Atherosclerosis; Obesity; NAFLD; α-Sma; alpha smooth muscle actin (α-Sma); BA; bile acid; BAT; brown adipose tissue; CEBPα; CCAAT/enhancer-binding protein α; Col1α1; collagen type 1 α1; DIO; diet-induced obesity; FXR; far
Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease
Keywords: ADAMTS; a disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs; BMP; bone morphogenic growth factor; DEXA; longitudinal dual energy x-ray absorptiometry; ECM; extracellular matrix; FBN; fibrillin; LTBP; latent TGFβ binding prot
Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds
Keywords: α-SMA; alpha-smooth muscle actin; ACE; angiotensin converting enzyme; ARB; angiotensin II type 1 receptors blocker; AT1R; angiotensin II type 1 receptors; AT2Râ/â; angiotensin II type 2 receptor knockout; MAPK; mitogen-activating protein kinase; RAS;
CtBP represses Dpp-dependent Mad activation during Drosophila eye development
Keywords: Drosophila; TGFβ; Punt (Put); CtBP; Ago; PMad; Photoreceptor differentiation; Tissue growth;
Crim1 is required for maintenance of the ocular lens epithelium
Keywords: Crim1; Lens epithelium; Lens fibers; TGFβ; Fiber differentiation;
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
Keywords: Biomimetic materials; Liver stem cells; Bioengineering; Organogenesis; iPSC; induced pluripotent stem cell; IH; iPSC derived hepatic progenitors; FDA; food and drug administration; TGFβ; transforming growth factor beta; 3D; three-dimensional; ICC; invert
Glucocorticoid hormone treatment enhances the cytokine production of regulatory T cells by upregulation of Foxp3 expression
Keywords: Dexamethasone; Treg; Foxp3; Glucocorticoid receptor; IL-10; TGFβ;
Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors
Keywords: AP-1; activator protein 1; CNI; calcineurin inhibitor(s); ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; ERK; extracellular signal regulated kinase; FKBP; FK506 binding protein; JNK; Jun N-terminal kinase; LAP; latency-associated pr
The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy
Keywords: Obstructive nephropathy; UUO model; Fibrosis, Notch3; TGFβ; ERK;
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
The ciliary protein Rpgrip1l in development and disease
Keywords: BB; Basal body; Bbs; Bardet-Biedl syndrome; C. elegans; Caenorhabditis elegans; CC; Coiled-Coil; Cep290; Centrosomal Protein 290; COACH; Cerebellar Vermis Aplasia Oligophrenia Congenital Ataxia Coloboma Hepatic Fibrosis; CRD; Cone Rod Dystrophy; Cux1; Cut
Cartilage oligomeric matrix protein: COMPopathies and beyond
Keywords: ATF6; activating transcription factor 6; ATP; adenosine triphosphate; BiP; binding immunoglobulin protein; BMD; bone mineral density; Chop; Mouse c/ebp homologous protein genes; CHOP; c/ebp homologous protein; COL9A1; human collagen type 9 Alpha 1 chain g
Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation
Keywords: Ang-II; angiotensin-II; CKD; chronic kidney disease; H2S; hydrogen sulfide; SCFA; short chain fatty acid; GYY; GYY4137 dichloromethane complex; WT; wild type; GFR; glomerular filtration rate; Olfr78; olfactory receptor 78; Rorc; RAR-related orphan recepto
Towards topical microRNA-directed therapy for epidermal disorders
Keywords: cSCC; cutaneous squamous cell carcinoma; DOTAP; 1,2-dioleoyloxy-3-trimethylammonium propane; DOPE; 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; hBD-2; human beta defensin 2; IFNγ; interferon gamma; IL; interleukin; Keratin 17; KRT17; LCNPs; liquid crys
MYH9: Structure, functions and role of non-muscle myosin IIA in human disease
Keywords: NM IIA; non-muscle myosin IIA; NMHC IIA; non-muscle myosin heavy chain IIA; NM IIB; non-muscle myosin IIB; NMHC IIB; non-muscle myosin heavy chain IIB; NM IIC; non-muscle myosin IIC; NMHC IIC; non-muscle myosin heavy chain IIC; NM II; non-muscle myosin II
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors
Keywords: ADCC; antibody dependent cell-mediated cytotoxic activity; ALL; acute lymphoid leukemia; AML; acute myeloid leukemia; CXCL; C-X-C motif chemokine ligand; ECM; extra-cellular matrix; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulat
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
TGFβ pathway inhibition in the treatment of non-small cell lung cancer
Keywords: ALK; Anaplastic leukemia kinase; CAF; Cancer-associated fibroblast; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; MSC; Mesenchymal stem cell; NK Cell; Natural killer cell; NSCLC; Non-small cell lung cancer; OS; Overall
Inhibition or ablation of transglutaminase 2 impairs astrocyte migration
Keywords: Transglutaminase 2; Astrocytes; Migration; TGFβ; Transamidation;
Regulation of fetal male germ cell development by members of the TGFβ superfamily
Keywords: Germ cells; TGFβ; Activins; Nodal; Cripto;
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro
Keywords: Transforming growth factor β1; Glycolysis; PFKFB3; Snail; TGFβ; transforming growth factor-β; EMT; epithelial-mesenchymal transition; PFKFB; 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase; F2,6BP; fructose 2,6-bisphosphate;