Toll-like receptors on the fork roads between innate and adaptive immunity
Keywords: TLR; Autoimmunity; Innate and adaptive immunity;
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Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway
Keywords: ERK; extracellular signal-regulated kinase; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MEK; MAPK-ERK kinase; NOx; nitric oxide metabolite; TNF-α; tumor necrosis factor-alpha; ROS; reactive oxygen species; TLR; Toll-like receptor; Ï
In vitro lipopolysaccharide treatment alters regulatory T cell properties in chickens
Keywords: LPS, lipopolysaccharide; TLR, toll-like receptorChicken Tregs; Inflammation; LPS; TLR
MyD88-dependent toll-like receptor signaling is required for murine macrophages response to IS2
Keywords: β-glucan; IS2; TLR; MyD88; MAPKs;
Prostaglandin E2 enhances IL-33 production by dendritic cells
Keywords: BMDC; bone marrow-derived dendritic cell; DC; dendritic cell; ELISA; enzyme-linked immunosorbent assay; FCS; fetal calf serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GM-CSF; granulocyte-macrophage colony stimulating factor; IL; interleukin; LPS;
Fibrosis and immune dysregulation in systemic sclerosis
Keywords: Th2 cells; Fibrosis; TLR; Pro-fibrogenic chemokines; Autoantibodies; Systemic sclerosis
Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
Keywords: T cells; Toll-like Receptors; TLR; TLR agonists; TLR ligands; TLR expression; Vaccination
Percutaneous Lower-extremity Arterial Interventions with Primary Balloon Angioplasty Versus SilverHawk Atherectomy and Adjunctive Balloon Angioplasty: Randomized Trial
Keywords: PTA; percutaneous transluminal angioplasty; TLR; target lesion revascularization; TVR; target vessel revascularization;
Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1
Keywords: GPI; glycosylphosphatidylinositol; PAMP; pathogen-associated molecular pattern; TLR; Toll-like receptor; BMDM; bone marrow derived macrophages; Plasmodium falciparum; Glycosylphosphatidylinositol anchors; Toll-like receptors; TLR2-TLR1/TLR6; Recognition
Research ArticleToll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis
Keywords: TLR; toll like receptor; NOD; nucleotide-binding oligomerisation domain; SBP; spontaneous bacterial peritonitis; SNP; single nucleotide polymorphism; OR; odds ratio; PMN; polymorphonuclear neutrophil; MELD; model of end-stage liver disease; CI; confidence
Recombinant YopJ induces apoptotic cell death in macrophages through TLR2
Keywords: rYopJ; recombinant yersinia outer protein J; TLR; toll like receptor; MAPK; mitogen-activated protein kinases; PAMP; pathogen associated molecular pattern; PRR; pattern recognition receptors; IRAK; IL-1 receptor-associated kinases; SB 202190; inhibitor of
Porcine Toll-like receptors: Recognition of Salmonella enterica serovar Choleraesuis and influence of polymorphisms
Keywords: ELAM-1; endothelial leukocyte adhesion molecule-1; LRR; leucine-rich repeat; PRR; pattern recognition receptor; SC; Salmonella enterica serovar Choleraesuis; ST; Salmonella enterica serovar Typhimurium; TIR; Toll/interleukin-1 receptor; TLR; Toll-like rec
Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress
Keywords: LPS; lipopolysaccharide; TLR; Toll-like receptors; TNFα; tumor necrosis factor-α; NF-κB; nuclear factor-κB; MAPK; mitogen activated protein kinase; STAT; signal transducers and activators of transcription; ALT; alanine aminotransferase; WT; wild-type;
Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE2 production is mediated by suppression of NF-κB and AP-1 activation signaling cascade
Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors; MAPK; mitogen activated protein kinase; NF-κB; nuclear factor-κB;
Sequence analysis of Toll-like receptor genes 1-10 of goat (Capra hircus)
Keywords: TLR; Toll-like receptor; cDNA; complementary DNA; SMART; simple modular architecture research tool; MEGA; molecular evolution and genetic analysis; TIR; Toll-interleukin 1 receptor domain; Toll-like receptors; Sequencing; sequence analysis; Simple modular
Tick saliva regulates migration, phagocytosis, and gene expression in the macrophage-like cell line, IC-21
Keywords: ERK; extracellular signal-regulated kinase; IRAK; interleukin-1 receptor associated kinase; TGF-β; transforming growth factor-beta; SGx; salivary gland extract; PDGF; platelet-derived growth factor; PACE; phosphoantibody cell-based ELISA; EDTA; ethylened
Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
Keywords: TLR; SLE; B cell; Autoimmune disease
Dynamics of leukocyte receptors after severe burns: An exploratory study
Keywords: Fc; Constant region on Ig; FTB%; Full thickness burn in % of body area; LPS; Lipopolysaccharide; MFI; Mean fluorescence intensity; MOF; Multiple organ failure; PMN; Polymorphonuclear leukocytes; TBSA%; Total burned surface area in % of body area; TLR; Tol
The response to TLR ligation of human CD16+CD14− monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus
Keywords: Monocyte subset; TLR; Viral infection; Hepatitis C virus
Avian-specific TLRs and downstream effector responses to CpG-induction in chicken macrophages
Keywords: LPS; lipopolysaccharide; TLR; toll-like receptor; MyD88; myeloid differentiation primary response gene 88; ODN; oligonucleotide; NLR; nod-like receptor; PRR; pattern recognition receptor; PAMP; pathogen associated molecular patterns; RLR; RIG-I like recep
How vaccinia virus has evolved to subvert the host immune response
Keywords: Bcl-2; B-cell lymphoma-2; CPXV; Cowpox virus; dsDNA; double-stranded DNA; ECTV; ectromelia virus; GAGs; glycosaminoglycans; GPCRs; G-protein coupled receptors; IFN; interferon; IG; immunoglobulin; PDB; protein data bank; RPXV; rabbitpox virus; r.m.s.d.; r
Overexpressing autoimmune regulator regulates the expression of toll-like receptors by interacting with their promoters in RAW264.7 cells
Keywords: Aire; autoimmune regulator; TLR; toll-like receptor; RAW264.7; mouse macrophage-like cell line; APECED; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APS-1; autoimmune polyendocrine syndrome type I; mTEC; medullary thymic epithelial cell
Tetraspanins in the immune response against cancer
Keywords: APC; antigen-presenting cell; BCR; B cell receptor; DC; dendritic cell; GPI; glycosylphosphatidylinositol; IFN; interferon; IL; interleukin; LEL; large extracellular loop; LPS; lipopolysaccharide; MHC; major histocompatibility complex; mDC; myeloid dendri
Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice
Keywords: CpG motif; unmethylated CpG dinucleotide; TLR; Toll-like receptor; LPS; lipopolysaccharide; ROS; reactive oxygen species; RA; rheumatoid arthritis; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; ODN; oligodeoxynucleotide; PO; phosphodiester; PS; phosphoroth
PLTP regulates STAT3 and NFκB in differentiated THP1 cells and human monocyte-derived macrophages
Keywords: ABCA1; ATP-binding cassette transporter A1; IFNγ; interferon gamma; IL1α; interleukin 1 alpha; JAK2; Janus kinase-2; LPS; lipopolysaccharides; MIP1α; macrophage inflammatory protein 1 alpha; NFκB; nuclear factor kappa-B; PLTP; phospholipid transfer pr
Regulation of remyelination in multiple sclerosis
Keywords: Remyelination; Oligodendrocytes; Hyaluronan; Wnt; Notch1; Retinoid X receptor; 15d-PGJ(2); 15-deoxy-Î12,14-prostaglandin J2; CNP; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; cKO; conditional knockout; dpl; days post l
Research ArticleThe Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway
Keywords: HBeAg; hepatitis B e antigen; HBV; hepatitis B virus; CHB; chronic hepatitis B; HBcAg; hepatitis B core antigen; NF-κB; nuclear factor kappa B; TNF-α; tumor necrosis factor alpha; TLR; Toll-like receptor; TIR; Toll/IL-1 receptor; IL; interleukin; IFN; i
Research ArticleEvidence of neutrophil functional defect despite inflammation in stable cirrhosis
Keywords: TLR; toll-like receptor; FACS; fluorescence activated cell sorter; GMFI; geometric mean of fluorescence intensity; Liver cirrhosis; Toll like receptors; Bacterial translocation; Phagocytosis; Oxidative burst; Cytokines; Neutrophil;
Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin
Keywords: Mycobacteria; Tuberculosis; Dendritic cells; Epithelial cells; Innate immunity; APC; allophycocyanin; BCG; Mycobacterium bovis bacillus Calmette-Guérin; CFP; culture filtrate protein; CW; cell wall; IFN; interferon; IL-; interleukin; irr M. tb; γ-irradi
Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function
Keywords: DC; dendritic cell; TLR; toll like receptor; T1D; type 1 diabetes; PMA; Phorbol myristate acetate; LPS; lipopolysaccharide; Adjuvant; Autoimmunity; Cholera toxin-B (CTB); Dendritic cells; IDDM; Juvenile diabetes;
Research ArticleHepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway
Keywords: HCC; hepatocellular carcinoma; HBV; hepatitis B virus; IL-6; interleukin-6; MyD88; myeloid differentiation factor 88; TGF-β; transforming growth factor β; ERK; extracellular signal-stimulated kinase; TLR; Toll-like receptor; PI3K; phosphatidylinositol-3
Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
Keywords: α-LA; α-lactoalbumin; β-LG; β-lactoglobulin; AC; allergic conjunctivitis; AR; allergic rhinitis; ASD; autism spectrum disorder; ASD-IS; ASD-immune subtype; BMDM cells; bone marrow derived microglial cells; CNS; central nervous system; CNV; copy number
Involvement of the TREM-1/DAP12 pathway in the innate immune responses to Porphyromonas gingivalis
Keywords: TREM-1; Triggering Receptor Expressed on Myeloid cells 1; DAP12; DNAX activating protein of 12Â kDa; qPCR; quantitative real-time polymerase chain reaction; TLR; Toll-like receptor; IL; interleukin; TREM-1; DAP12; LP17; MonoMac-6; Porphyromonas gingivalis
Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles
Keywords: Polysaccharides; Poly(I:C); Nanoparticles; Targeted delivery system; TLR; ImmunogenicityAFM, Atomic Force Microscopy; BMDC, Bone marrow derived dendritic cell; HEK, Human embryonic kidney; NOD, Nucleotide-binding oligomerization domain; ODN, Oligodeoxynuc
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Keywords: OA; osteoarthritis; RA; rheumatoid arthritis; DRG; dorsal root ganglia; MMP; matrix metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; UTRs; untranslated regions; TLR; Toll-like receptor; NFkB; nuclear factor-kappa
Toll-like receptors and interferon associated immune factors in viral haemorrhagic septicaemia virus-infected olive flounder (Paralichthys olivaceus)
Keywords: Viral haemorrhagic septicaemia virus (VHSV); Olive flounder (Paralichthys olivaceus); TLR; IRF; ISG 15
Review ArticleAir pollution: An environmental factor contributing to intestinal disease
Keywords: CI; confidence interval; DEP; diesel exhaust particles; IBD; inflammatory bowel diseases; IFN; interferon; IL; interleukin; OR; Odds ratio; PM; particulate matter; TLR; toll-like receptor; TNF; tumor necrosis factor; Air pollution; Particulate matter; Inf
A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates
Keywords: Crassostrea gigas; TLR; TLR pathway; Innate immunity; Invertebrate
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
Keywords: Prenatal; farm animal; Toll-like receptors; atopic dermatitis; gene-environment interaction; EFRAIM; Mechanism of Early Protective Exposures on Allergy Development; GEE; General estimating equation; GMR; Geometric mean ratio; ISAAC; International Study of
Rejet de la greffe rénale : mécanisme et prévention
Keywords: Rejet d’allogreffe; Suivi immunologique; TLR; C4d; Immunosuppresseurs; Biopsie rénaleAllograft rejection; Immunological monitoring; TLR; C4d; Immunosuppressors; Renal biopsy
Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes
Keywords: Liposomes; Vaccine; Immune response; CpG DNA; TLR; Nanotechnology
Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection
Keywords: BMDC; bone marrow derived dendritic cell; DC; dendritic cell; TLR; toll like receptor; Aging; Influenza viral infection;
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils
Keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
Perioperative Cognitive Decline in the Aging Population
Keywords: Aβ; β-amyloid; AD; Alzheimer disease; apoE; apolipoprotein E; APP; amyloid precursor protein; DAMPs; damage-associated molecular patterns; HMGB-1; high mobility group box chromosomal protein 1; IL; interleukin; POCD; postoperative cognitive dysfunction;
Douleur et immunité
Keywords: Nocicepteurs; Douleur neuropathique; Allodynie; TLR; IL-1β; TNF-α; Résolvines; Synapse neuro-immune;
Endovascular Revascularization of Below-the-Knee Arteries: Prospective Short-Term Angiographic and Clinical Follow-Up
Keywords: ABI; ankle-brachial index; BTK; below the knee; CI; confidence interval; CLI; critical limb ischemia; HR; hazard ratio; IC; intermittent claudication; TER; target extremity revascularization; TLR; target lesion revascularization;
ReviewToll-like receptors in acute liver injury and regeneration
Keywords: TLR; Innate immunity; Liver injury; Liver regeneration;
TLRs, macrophages, and NK cells: Our understandings of their functions in uterus and ovary
Keywords: TLR; Macrophage; NK cells; Ovary; Uterus; PPAR;
Research ArticleDSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
Keywords: NASH; non-alcoholic steatohepatitis; DSS; dextran sulfate sodium; SC; standard chow; HF; high fat; IL-1; interleukin 1; TNF; tumor necrosis factor; TLR; toll-like receptor; MCP-1; monocyte chemoattractant protein 1; TIMP-1; tissue inhibitor of metalloprot
The Aicardi-Goutières syndrome. Molecular and clinical features of RNAse deficiency and microRNA overload
Keywords: AGS; Aicardi-Goutières syndrome; TLR; Toll-like receptor; IFN-alpha; interferon alpha; CSF; cerebrospinal fluid; RNase deficiency; MicroRNA overload; Basal ganglia calcifications; Interferon alpha; Aicardi-Goutières syndrome;