Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress

► Activation of STAT1 and NF-κB inflammation signaling in LPS-exposed Ppara-null Mice. ► Elevation of pro-inflammatory cytokines and chemokines in LPS-exposed Ppara-null mice. ► Inhibition of anti-oxidant enzymes and mitochondrial complexes after LPS exposure. ► Increased lipid peroxidation and protein nitration in LPS-exposed Ppara-null mice. ► More severe LPS-induced acute liver damage in Ppara-null mice than WT mice.