دانلود مقالات ISI درباره Tmax + ترجمه فارسی

Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine

Keywords: AUC; area under the concentration-time curve in blood; bw; body weight; cx-MPHP(-d4); non- or ring-deuterated mono-(2-propyl-6-carboxyhexyl) phthalate; cx-MPHP; mono-(2-propyl-6-carboxyhexyl) phthalate; cx-MPHP-d4; ring-deuterated mono-(2-propyl-6-carboxy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba

Keywords: AUC; area under the plasma concentration-time curve; BS; Radix Paeoniae Alba; CID; collision-induced dissociation; CL; clearance; Cmax; maximum plasma concentration; FDA; US Food and Drug Administration; HPLC/UV; high performance liquid chromatography/u

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Heterogeneity of auto-antibodies against nAChR in myasthenic serum and their pathogenic roles in experimental autoimmune myasthenia gravis

Keywords: Ab; antibody; α-Btx; alpha-Bungarotoxin; CDC; complement dependent cytotoxicity; cpm; count per minute; Cmax; maximum plasma concentration; EAMG; experimental autoimmune myasthenia gravis; EDL; extensor digitorum longus; Fab; Fab fragment of monoclonal a

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Numerical and experimental investigations of the effects of the second injection timing and alcohol-gasoline fuel blends on combustion and emissions of an HCCI-DI engine

Keywords: HCCI-DI; Second injection; CFD simulation; Ethanol; Methanol; aBDC; After bottom dead center; aTDC; After top dead center; bBDC; Before bottom dead center; bTDC; Before top dead center; CI; Compression ignition; DI; Direct injection; GDI; Gasoline direct

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Cyanobacteria Biorefinery - Production of poly(3-hydroxybutyrate) with Synechocystis salina and utilisation of residual biomass

Keywords: ΔHm; melting enthalpy; ATR-FTIR; attenuated total reflection Fourier-transform infrared spectroscopy; BMP; biochemical methane potential; CH4; biomethane; ĐM; polydispersity index; DSC; differential scanning calorimetry; GPC; gel permeation chromatograp

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Repeated administration of Sailuotong, a fixed combination of Panax ginseng, Ginkgo biloba, and Crocus sativus extracts for vascular dementia, alters CYP450 activities in rats

Keywords: Sailuotong; Panax ginseng; Ginkgo biloba; Crocus sativus; CYP450; Herb-drug interaction; Abbreviation: SLT; Sailuotong; VD; vascular dementia; TCM; traditional Chinese medicines; DDI; drug-drug interaction; CYP450; cytochrome P450; SPE; solid phase extrac

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetic differences of mifepristone between sexes in animals

Keywords: UPLC-MS/MS; ultra-performance liquid chromatography-tandem mass spectrometry; IS; internal standard; NADPH; nicotinamide adenine dinucleotide phosphate; QC; quality control; Cmax; maximum concentration; Tmax; time to peak; t1/2; half-life period; MRT; a

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetics and safety of a single dose of the novel LAMA/LABA fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler, formulated using co-suspension delivery technology, in Japanese healthy subjects

Keywords: GFF MDI; Chronic obstructive pulmonary disease; Co-suspension delivery technology; LAMA/LABA; Pharmacokinetics; AE; adverse event; AUC0-12; area under the curve from 0 to 12 h; AUC0-t; area under the curve from 0 to time of the last measurable plasm

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats

Keywords: AD; alzheimer's disease; AUCINF; area under the concentration time curve from time zero to the last sampling time plus the extrapolated area (i.e., the last concentration divided by the elimination rate constant); AUClast; area under the concentration t

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies

Keywords: Brain targeting; Drug delivery; Intranasal; In vivo; Nanosystem; Pharmacokinetics; ATCC; anatomical therapeutic chemical classification; AUC; area under the curve; BBB; blood-brain barrier; B%brain IN/IV; comparative brain bioavailability (IN vs IV); DTE%

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Safety and pharmacokinetics of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler (BGF MDI) in healthy adult subjects of Japanese descent

Keywords: Chronic obstructive pulmonary disease; Co-suspension delivery technology; ICS/LAMA/LABA; Western; Japanese; Triple fixed-dose combination; AE; adverse event; AUC0-12; area under the plasma concentration-time curve from 0 to 12 h; AUC0-∞; area un

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Linking building energy consumption with occupants' energy-consuming behaviors in commercial buildings: Non-intrusive occupant load monitoring (NIOLM)

Keywords: Non-intrusive approach; Data mining; Power change; Occupant energy-use behavior; Commercial buildings; Wi-Fi network; Aggregate load data; ΔT; Time interval, measured in seconds; ΔP; Magnitude of power changes, measured in watts; Pmin; Threshold for an

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation

Keywords: AUC; area under the curve; BE; bioequivalence; CI; confidence interval; CL; clearance; Cmax; maximum plasma concentration; CR; controlled release; CV; coefficient of variation; f2; similarity factor; FTFF; the fastest tablet of the fastest dissolving form

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility

Keywords: amorphous; drug-excipient interaction; gastrointestinal transit; oral absorption; poorly water-soluble drugs; solid dispersion; AUC; area under the curve of blood concentration versus time curve; ASD-MEL/EUD; amorphous solid dispersion of meloxicam with p

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design

Keywords: ASD; amorphous solid dispersion; ATR; attenuated total reflectance; AUC; area under the curve; BCS; Biopharmaceutic Classification System; CEL; celecoxib; Cmax; maximum concentration, or peak kinetic solubility; CR; controlled release; CRASD; controlled r

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology

Keywords: ANOVA; analysis of variance; AUC; area under the curve of plasma concentration vs. time; BA; oral bioavailability; BCS; biopharmaceutics classification system; BMA; butyl methacrylate; Cmax; maximum concentration; DLS; dynamic light scattering; GI; gastro

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice

Keywords: ACV; Acyclovir; AUC0-180; Area under the plasma concentration-time curve from 0 to 180 min; CL; Clearance; Cmax; Maximum plasma concentration; F; Bioavailability; Gly-Sar; glycylsarcosine; huPepT1; Humanized peptide transporter 1; Inu; Inulin; Km; Micha

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; ANOVA; analysis of variance; AUC; area under plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BTB; blood-testis barrier; Cbrain; brain concentrat

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats

Keywords: Guizhi Fuling capsule; Primary dysmenorrhea; Pharmacokinetic-pharmacodynamic model; Anti-dysmenorrhea effect; Ratios of PGE2/PGF2α and 6-Keto-PGF1α/TXB2; ALB; albiflorin; AMY; amygdalin; ARA; arachidonic acid; AUC0-t; area under the time-concentration

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats

Keywords: AH-7921; Analgesia; Metabolism; Pharmacokinetics; Rewarding effect; 2-Prop; iso-propylic alcohol; ACN; acetronitrile; ANOVA; analysis of variance; AUC; area under the curve; BBB; blood-brain-barrier; CID; collision-induced dissociation; Cmax; peak concent

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Population pharmacokinetic evaluation of ADV6209, an innovative oral solution of midazolam containing cyclodextrin

Keywords: λz; terminal elimination rate constant; AUC0 → ∞;  area under the concentration-time curve from zero to infinity with extrapolation of the terminal phase; AUC0 → Tlast.; area under the concentration-time curve from zero to the last time point;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Geochemical and geological characterization of marine-continental transitional shales from Longtan Formation in Yangtze area, South China

Keywords: Organic geochemistry; Marine-continental shale; Longtan formation; Microscopic pores; Yangtze area; Shale gas; EIA; Energy Information Administration; OM; organic matter; TOC; total organic carbon; Ro; vitrinite reflectance; Fm; Formation; GC-MS; gas ch

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

Keywords: ADME; absorption, distribution, metabolism and excretion; AUC0-t(last); area under the concentration-time curve up to the last measurable concentration; AUCinf; area under the concentration-time curve up to infinity; AUCτ; area under the concentration-ti

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review

Keywords: AM; Atractylodes macrocephala Koidz.; TCM; traditional Chinese medicine; UPLC; ultra-performance liquid chromatography; PDA; photo-diode array; IR; infrared spectroscopy; HS-LP-LPE; headspace liquid phase-liquid-phase extraction; GC-MS; gas chromatography

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

Keywords: Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Nucleosidic DNA demethylating epigenetic drugs - A comprehensive review from discovery to clinic

Keywords: ALL; Acute lymphoblastic leukemia; AML; Acute myeloid leukemia; AUC; Area under the curve; AZA; 5-azacytidine; 5-aza-CdR; 2′-deoxy-5-azacytidine; 5-aza-CR; 5-azacytidine; AZN; Azanucleosides; BED; Biologically effective dose; BSC; Best supportive care;

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2018 سفارش ترجمه

Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae-A traditional medicine: A review

Keywords: Qinjiao; Phytochemical; Pharmacology; Pharmacokinetic; Quality control; Authentication; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under curve; 6-BA; 6-benzylaminopurine; CCl4; carbon tetrachloride; Cl; clearance; Cmax; conc

دانلود رایگان متن کامل مقاله ISI 124 صفحه سال انتشار : 2018 سفارش ترجمه

Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study

Keywords: FACS; Fluorescence activated cell sorting; γ-GC; gamma-glutamylcysteine; GCL; glutamate cysteine ligase holoenzyme; GCLC; catalytic subunit of glutamate cysteine ligase; GCLM; modifier subunit of glutamate cysteine ligase; GR; glutathione reductase; γ-G

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Predicting water absorption of wheat flour using high shear-based GlutoPeak test

Keywords: Wheat quality; Flour water absorption; GlutoPeak; Farinograph; CNHR; Canada Northern Hard Red; CPSR; Canada Prairie Spring Red; CWHWS; Canada Western Hard White Spring; CWRS; Canada Western Red Spring; CWRW; Canada Western Red Winter; FAB; Farinograph Abs

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

A rapid and sensitive UHPLC-MS/MS method for quantification of 83b1 in plasma and its application to bioavailability study in rats

Keywords: UHPLC-MS/MS; ultra-high performance liquid chromatography tandem mass spectrometry; ESCC; esophageal squamous cell carcinoma; PPAR; peroxisome proliferator-activated receptor; CDDP; cisplatin; COX-2; cyclooxygenase-2; PGH; prostaglandin H; MTS; 3-(4,5-d

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies

Keywords: AUC0→24; area under the curve from time zero to 24 h; AUC0→∞; area under the curve from time zero to infinity; AUMC0→∞; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; IS; internal s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics and pharmacodynamics of a buprenorphine subcutaneous depot formulation (CAM2038) for once-weekly dosing in patients with opioid use disorder

Keywords: AUC0-7d; area under the concentration-time curve from time of dosing to 7 days; AUC0-last; area under the concentration-time curve from time zero to last observed concentration; AUC0-∞;  area under the concentration-time curve from time ze

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study

Keywords: AUC0-t; area under the peak-time curve from time zero to last sampling time; ESI; electrospray ionization; IS; internal standard; Ke; elimination rate constant; LLOQ; lower limit of quantification; MRM; multiple reaction monitoring; t1/2; biological hal

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Quantification of EC-18, a synthetic monoacetyldiglyceride (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), in rat and mouse plasma by liquid-chromatography/tandem mass spectrometry

Keywords: ACN; acetonitrile; AUC0→∞; area under the curve from time zero to infinity; AUMC0→∞; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; FA; formic acid; IPA; isopropyl alcohol; IS; interna

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model

Keywords: EPR; enhanced permeability and retention; H&E; hematoxylin and eosin; IA; intraarterial; IV; intravenous; MPM; macromolecule polymeric micelle; Tmax; time of maximum concentration; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP nick-end labe

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetic based study on “lagged stimulation” of Curcumae Longae Rhizoma - Piper nigrum couplet in their main active components' metabolism using UPLC-MS-MS

Keywords: Curcumae Longae Rhizoma; Piper nigrum; UHPLC-MS-MS; Lagged stimulation; Pharmacokinetics; TCM; Traditional Chinese Medicine; Cur; curcumin; Pip; piperine; UPLC-MS-MS; ultra-performance liquid chromatography-mass spectrometry; ESI; electrospray ionizatio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects

Keywords: Neuromedin U (NMU); NMU-8; Polyethylene glycol (PEG); Diabetes; Obesity; NMU; neuromedin U; PEG; polyethyleneglycol; PipAc; 2-(piperazin-1-yl)acetic acid; CNS; central nervous system; DIO; diet-induced obesity; EMCS; N-(6-maleimidocaproyloxy)succinimide;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro and In Situ Characterization of Triterpene Glycosides From Cimicifuga racemosa Extract

Keywords: Biopharmaceutics Classification System (BCS); cell culture; dissolution; solubility; gastrointestinal; LC-MS; absorption; Caco-2 cells; natural products; Ze 450; Cimicifuga racemosa extract; BCS; Biopharmaceutics Classification System; ab; apical-to-baso

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Keywords: Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Assessment of intra- and inter-regional interrelations between GABA+, Glx and BOLD during pain perception in the human brain - A combined 1H fMRS and fMRI study

Keywords: 1H; proton; BOLD; blood oxygenation level dependent; CSF; cerebral spinal fluid; EPI; echo planar imaging; fMRI; functional magnetic resonance imaging; fMRS; functional magnetic resonance spectroscopy; FWE; family wise error; FWHM; full width at half maxi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, excretion balance, and tissue distribution of [14C]-labeled glycolipids and long chain fatty acids from Dacryopinax spathularia in rats

Keywords: Jelly mushroom glycolipids; Natural preservative; Bioavailability; Long chain fatty acids; AUC; area under the concentration versus time curve; BLQ; below the quantitation limit; CMC; carboxymethylcellulose; Cmax; peak concentration; DN; dose normalized;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

β-Cyclodextrin-based supramolecular poly(N-isopropylacrylamide) hydrogels prepared by frontal polymerization

Keywords: N-isopropylacrylamide (PubChem CID: 16637); N,N′-methylene-bis-acrylamide (PubChem CID: 168964); Dimethylsulfoxide (PubChem CID: 679); CD; Cyclodextrin; αCD; α-cyclodextrin; βCD; β-cyclodextrin; γCD; γ-cyclodextrin; FP; frontal polymerization; PPR

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Oxidation Tmax: A new thermal maturity indicator for hydrocarbon source rocks

Keywords: Pyrolysis; Thermal oxidation; Tmax; Maturity; LECO; Rock-Eval; Source rock;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats

Keywords: Gymnema sylvestre; Diabetes; Triterpenoids; Steroids; Pharmacokinetic; CYP450-Herb drug interaction; CYP; CytochromeP450; PK; Pharmacokinetics; GS; Gymnema sylvestre; HDI; Herb drug interaction; EL; Ethanolic extract; GA; Gymnemic acid; HRLC-MS; High reso

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Tetrahydrocannabinol Does Not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study

Keywords: Marijuana; Chronic Pain; AE; Randomized Controlled Trial; AE; adverse event; AppLe; appetite level; AUC; area under the curve; CI; confidence interval; Cmax; maximum plasma concentration; CP; chronic pancreatitis; NRS; numeric rating scale; PGIC; patient

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)

Keywords: ABC; ATP-binding cassette; CYP; cytochrome P450; KTC; ketoconazole; MDR/MXR; multidrug/multixenobiotic resistance; P-gp; P-glycoprotein; PCN; pregnenolone 16α-carbonitrile; PXR; pregnane X-receptor; ARmax; maximum accumulation rate; Cmax; maximum concent

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Keywords: API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه