دانلود مقالات ISI درباره Tmax + ترجمه فارسی

Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice

Keywords: Metformin; OCT3; Transporter; Intestinal absorption; Bioavailability; Mouse; AUC; area under the plasma concentration-time curve; CL; clearance; Cmax; maximum concentration; OCT/Oct; organic cation transporter; SLC; solute carrier; tmax; time to maximum

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant

Keywords: (2R,4R)-Monatin; QT prolongation; QTc; TQT study; Food ingredient; ADME; absorption, distribution, metabolism, and elimination; AE; adverse event; Ae; amounts excreted; AUC0-inf; area under the plasma concentration-time curve to infinite time; AUC0-t; a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA

Keywords: AE; adverse event; BSID-III; Bayley Scales of Infant and Toddler Development, Third Edition; CSF; cerebrospinal fluid; CNS; central nervous system; DQ; developmental quotient; EC; Enzyme Commission; ELISA; enzyme-linked immunosorbent assay; GAG; glycosami

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues

Keywords: Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Deglycosylation and absorption of marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside from capitula of Coreopsis tinctoria in rats and humans

Keywords: Coreopsis tinctoria; Flavonoid glycoside; Flavonoid aglycone; Pharmacokinetic profile; Deglycosylation; TDG; taxifolin-7-O-β-D-glucopyranoside; CCT; the capitula of Coreopsis tinctoria; CCTE; the extract of CCT; GIT; gastrointestinal tracts; AUC; the are

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Tolerability, exposure and pharmacokinetics in healthy subjects of a Chinese herbal medicine MaZiRenWan (MZRW): Study protocol for a randomized open-labelled, three-arm phase 0/1 clinical trial

Keywords: MZRW; MaZiRenWan; AUC; the area under the plasma concentration-time curve; Cmax; the peak plasma concentration of an ingredient after administration; tmax; the time to reach Cmax; t1/2; the elimination half-life; CL; clearance; ADME; the absorption, distr

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study

Keywords: ACN; acetonitrile; AD; Alzheimer disease; AUCtotal; area under curve/bioavailability; CAS; catalytic anionic site; Cmax; maximal plasma concentration; CL; clearance; FDA; US Food and drug administration; hAChE/AChE; human acetylcholinesterase/acetylcholin

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Andrographis paniculata: Dissolution investigation and pharmacokinetic studies of four major active diterpenoids after multiple oral dose administration in healthy Thai volunteers

Keywords: 1; andrographolide; 2; 14-deoxy-11, 12-didehydroandrographolide; 3; neoandrographolide; 4; 14-deoxyandrographolide; AUC; area under plasma concentration-time curve; Cmax; maximum concentration; Cl; clearance; EDTA; ethylenediaminetetraacetic acid; F; bioa

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Bioequivalence and food effect of heat-stressed and nonâ¿¿heat-stressed dapagliflozin 2.5- and 10-mg tablets

Keywords: AUC0â¿¿t; area under the plasma concentrationâ¿¿time curve from time 0 to the last quantifiable concentration; AUC0â¿¿inf; area under the plasma concentrationâ¿¿time curve from time 0 to infinity; Cp; plasma concentration; Cmax; maximum Cp; Dapagliflozin;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy

Keywords: DSF; disulfiram; mPEG-PLGA; methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide); PCL; poly(ε-caprolactone); NPs; nanoparticles; DMF; N,N′-dimethylformamide; CH3CN; acetonitrile; DLS; dynamic light scattering; TEM; transmission electron microscop

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo

Keywords: ATCC; American Tissue Culture Collection; BBB; blood-brain barrier; CMC; critical micelle concentration; DL; drug loading; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DPH; 1,6-diphenyl-1,3,5-hexatriene; EE; encapsulation efficiency

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice

Keywords: Bevacizumab; Colorectal cancer; Curcumin; Turmeric; Turmerone; 5-FU; 5-fluorouracil; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under concentrationâ¿¿time curve; Cmax; maximum concentration; CK; creatine kinase; FBS; fetal b

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Is Thrombin Time useful for the assessment of dabigatran concentrations? An in vitro and ex vivo study

Keywords: HTI; Hemoclot Thombin Inhibitors®; ECA; Ecarin chromogenic assay; LOD; Limit of detection; LOQ; Limit of quantification; TT; Thrombin time; UFH; Unfractionated heparin; NPP; Normal pool plasma; PPP; Platelet-poor-plasma; NIH/ml; National Institutes of He

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacokinetic synergy from the taxane extract of Taxus chinensis improves the bioavailability of paclitaxel

Keywords: Taxus chinensis var. mairei; Paclitaxel; Bioavailability; Pharmacokinetic synergy; Tissue distribution; Cytotoxicity; PTX; paclitaxel; P-gp; P-glycoprotein; CYP; cytochrome P450; MRP2; multidrug resistance protein 2; Cmax; peak plasma concentration; Tmax;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma

Keywords: AED; anti-epileptic drugs; AMPA; α-amin-3-hydroxyl-5methyl-4isoxazolepropionic acid; AUC; area under the plasma concentration-time curve; AUC0-inf; AUC extrapolated to infinity; AUC0-last; AUC to the last time points; AUMC; area under the first mom

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacoscintigraphy studies to assess the feasibility of a controlled release formulation of ziprasidone

Keywords: AUCinf; area under the serum concentration-time profile from time 0 extrapolated to infinite time; BA; bioavailability; Cmax; maximum serum concentration; Tmax; time for Cmax; SCT; swellable core technology; CCSD; coated crystals made by spray drying; IR;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Idarubicin-Loaded ONCOZENE Drug-Eluting Embolic Agents for Chemoembolization of Hepatocellular Carcinoma: In Vitro Loading and Release and In Vivo Pharmacokinetics

Keywords: AE; adverse event; AUC0-24 h; area under the concentration-time curve from 0-24 hours; Cmax; maximum concentration; DEE; drug-eluting embolic; HCC; hepatocellular carcinoma; LLOQ; lower limit of quantification; MDR; multidrug resistance; PK; pharmacok

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiovascular pharmacologyCardiovascular safety pharmacology profile of etamicastat, a novel peripheral selective dopamine-ß-hydroxylase inhibitor

Keywords: DBH; dopamine-ß-hydroxylase; LC-MS/MS; liquid chromatography - mass spectrometry; AUC; area under plasma concentration-time curve; tmax; time to maximum concentration; t1/2; terminal half-life; Cmax; maximum concentration; LLOQ; lower limit of quanti

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats using LC-MS/MS and Q-TOF-MS methods

Keywords: AS; salicylic acid; AUC; area under the blood concentration-time curve; Cmax; maximum concentration; ESI; electrospray ionization; IS; internal standard; LC-MS/MS; liquid chromatography-mass spectrometry/mass spectrometry; MSL; methyl salicylate-2-O-β-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues

Keywords: AUC; area under curve; Cmax; maximum concentration; EC; (−)-epicatechin; EGC; (−)-epigallocatechin; EGCG; (−)-epigallocatechin gallate; GC; (−)-gallocatechin; GCG; (−)-gallocatechin gallate; GPx3; glutathione peroxidase-3; GSH; reduced glutathio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma

Keywords: Asthma; Fixed-dose combination; Muscarinic antagonist; Inhaled corticosteroid; Trough FEV1; Ae; amount of dose excreted unchanged in urine; AE; adverse event; ALT; alanine aminotransferase; AUC; area under the curve; BID; twice daily; bpm; beats per minut

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

Keywords: ADME; absorption, disposition, metabolism and excretion; Cmax; peak plasma concentration; CID; collision-induced dissociation; ESI; electrospray interface; GIT; gastrointestinal tract; PDA; photodiode array; Tmax; time to reach peak plasma concentration;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Les bases pharmacologiques de la thérapeutique. Analyse pharmacologique du résumé des caractéristiques d'un produit ( le « RCP ») pour le thérapeute

Keywords: résumé des caractéristiques d'un produit; RCP; pharmacologie; thérapeutique; summary of product caracteristics; SPC; pharmacology; therapeutics; AMM; autorisation de mise sur le marché; ANSM; Agence Nationale de Sécurité du Médicament et des pro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Toxicological evaluation of two flavors with modifying properties: 3-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)piperidin-1

Keywords: AUC; area under the curve; CL; plasma clearance; Cmax; peak plasma concentration; EIC; extracted ion chromatogram; FDA; Food and Drug Administration; FEMA; Flavor and Extract Manufacturers Association of the United States; FL-no; FLAVIS number; FMP; flavo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid

Keywords: ABZ; albendazole; ABZ-SO; Albendazole sulfoxide; ACN; acetonitrile; ALP; alkaline phosphatase; ANOVA; analysis of variance; AUC; area-under-the-curve; BBB; blood brain barrier; Cmax; maximum concentration; CUR; Curcumin; CYPs; cytochrome P450; DHA; docosa

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; AUC; area under the plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; Cmax; maximum drug concentration in plasma; EML4; echinoderm microtubule-ass

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Adaptation of the quality by design concept in early pharmaceutical development of an intranasal nanosized formulation

Keywords: API; active pharmaceutical ingredient; Cmax; maximum plasma concentration; CQA; critical quality attribute; CPP; critical process parameter; EMA; European Medicines Agency; FDA; Food and Drug Administration; HA; sodium hyaluronate; ICH; International Conf

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2015 سفارش ترجمه

Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment

Keywords: AA; arylamine(s); AUC; area under the curve; BMI; body mass index; bw; body weight; Cmax; maximal plasma concentration; HPLC/MS/MS; high performance liquid chromatography-tandem/mass spectrometry; IARC; International Agency for the Research of Cancer; Ke;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2015 سفارش ترجمه

14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations

Keywords: Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2015 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

Keywords: AUC0−∞; area under the plasma concentration-time curve; CDK; cyclin-dependent kinase; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; i.p.; intraperitoneal; IS; internal standard; MYCN; V-myc myelocytomatosis viral related

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Utilisation des médicaments par voie orale et syndrome de grêle court : analyse des pratiques

Keywords: syndrome du grêle court; médicaments; voies d'administration; prescriptions; short bowel syndrome; route of administration; drug prescriptions; ANOVA; analysis of variance; CEERB; Comité d'évaluation de l'éthique des projets de recherche médic

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetics of oral vitamin D3 and calcifediol

Keywords: AUC; area under the concentration vs time curve; Cmax; maximum concentration; Clast; concentration quantified before the next study drug intake; GMR; geometric mean ratio; HPLC; high performance liquid chromatography; tmax; time to reach Cmax; RCT; random

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibitory activity of sesaminol and sesaminol triglycoside on cytochrome P450 enzymes and their pharmacokinetics in rats

Keywords: STG; sesaminol triglycoside; CYPs; cytochrome P450; Cmax; the maximum plasma concentration; Tmax; the time to reach maximum plasma concentration; t1/2; the half-lives; AUC; the area under the drug concentration-time curve; Cl; clearance; Vd; volume of d

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Thermoregulation of the vibrissal system in harbor seals (Phoca vitulina) and Cape fur seals (Arctocephalus pusillus pusillus)

Keywords: CS; Cavernous sinus; F-SC; Follicle-sinus complex; IR; Infrared; Tair; Ambient air temperature; Tdiff; Temperature difference; Tfollicle; Temperature inside the vibrissal follicles; Tmax; Maximum temperature; Tmean; Mean temperature; Tmin; Minimum tem

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA)

Keywords: GCP-II; glutamate carboxypeptidase-II; PSMA; prostate specific membrane antigen; NAALADase; N-acetylated-alpha-linked acidic dipeptidase; NAAG; N-acetyl-aspartyl glutamate; 2-PMPA; 2-phosphonomethyl pentanedioic acid; 2-PMSA; 2-phosphonomethyl succinic ac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats

Keywords: CD; Cortex daphnes; GU; Glycyrrhizae uralenis; CD-GU; combination of CD and GU; TCHM; traditional Chinese herbal medicine; CYP; cytochrome; UGT; UDP-glucuronosyltransferase; Cmax; peak plasma concentration; Tmax; time to Cmax; AUC0-t; area under the c

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Controlled release of Lactobacillus rhamnosus biofilm probiotics from alginate-locust bean gum microcapsules

Keywords: AGN; alginate; AGN-LB; alginate-locust bean gum; AGN-XT; alginate-xanthan gum; CFU; colony forming unit; EPS; extracellular polymeric substance; HD; high density; LGG; Lactobacillus rhamnosus GG; MRS; de Man-Rogosa-Sharpe; PBS; phosphate buffer saline; SE

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract

Keywords: P; psoralen; IP; isopsoralen; PO; psoralenoside; IPO; isopsoralenoside; UPLC-MS/MS; ultra performance liquid chromatography tandem mass spectrometry; PCE; Psoralea corylifolia extract; PBGF; purified benzofuran glycosides fraction; TCM; traditional Chin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial

Keywords: Cough; transient receptor potential vanilloid 1; capsaicin; cough sounds; sensory nerves; C2; Concentration of capsaicin inducing at least 2 coughs; C5; Concentration of capsaicin inducing at least 5 coughs; CQLQ; Cough Quality of Life Questionnaire; HRT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Keywords: CYP; cytochrome P450; UGT; UDP-glucuronosyltransferase; S-Rg3; 20(S)-ginsenoside Rg3; R-Rg3; 20(R)-ginsenoside Rg3; S-Rh2; 20(S)-ginsenoside Rh2; R-Rh2; 20(R)-ginsenoside Rh2; NADP+; β-nicotinamide adenine dinucleotide phosphate; LC-MS/MS; liquid chrom

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Médicaments et grossesse : modifications pharmacocinétiques et place du suivi thérapeutique pharmacologique

Keywords: grossesse; pharmacocinétique; suivi thérapeutique des médicaments; réponse thérapeutique tératogène; pregnancy; pharmacokinetics; therapeutic drug monitoring; treatment outcome; teratogen; Cmax; concentration plasmatique maximale; CYP; cytochrome P

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steatohepatitis

Keywords: Fatty Liver Disease; Therapeutic Targets; Treatment; PDE4; AE; adverse event; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under the plasma drug concentration time curve; AUCtau; area under the plasma drug concentration time c

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetic interactions between topiramate and pioglitazone and metformin

Keywords: ANOVA; analysis of variance; AUC12; area under concentration-time curve over dosing interval of 12 h; AUC24; area under concentration-time curve over dosing interval of 24 h; BID; twice daily dosing; CI; confidence interval; CL/F; oral clearance; Cm

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Intramuscular Administration of Paliperidone Palmitate Extended-Release Injectable Microsuspension Induces a Subclinical Inflammatory Reaction Modulating the Pharmacokinetics in Rats

Keywords: prodrugs; nanoparticles; muscle; disposition; biocompatibility; pharmacokinetics; paliperidone palmitate; sustained release; histopathology; inflammation; API; active pharmaceutical ingredient; AUC; area under the (plasma concentration vs. time) curve; CL

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387

Keywords: AUC; area under the plasma concentration-time curve; Cmax; maximum drug concentration in plasma; Tmax; the time after administration of a drug when the maximum plasma concentration is reached; BBB; blood-brain barrier; BCRP; breast cancer resistance p

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Keywords: 5-HT2; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AM; allosteric modulator; AUC; area under curve; AUCINF; area under curve extrapolated to infinity; AUClast; area under curve from dosing to observation; AUMC; area under first moment curve; CL; total

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Stinky tofu as a rich source of bioavailable S-equol in Asian diets

Keywords: ODMA; O-desmethylangolensin; ERmax; maximum excretion rate; Tmax; time to reach maximum excretion rate; Stinky tofu; Fermented soy food; Equol; Isoflavone; Urine kinetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: Safety profiling

Keywords: LC-MS/MS; Liquid Chromatography-Mass Spectroscopy/Mass Spectroscopy; MET; metoprolol succinate; TEL; telmisartan; IS; Internal Standard; CPCSEA; Committee for the Purpose of Control and Supervision of Experiments on Animals; IAEC; Institutional Animal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

A GPP assimilation model for the southeastern Tibetan Plateau based on CO2 eddy covariance flux tower and remote sensing data

Keywords: Com-MODEL; assimilation model in the three sites; DL; Dali station; DL-MODEL; assimilation model in Dali site; EVI; enhanced vegetation index; fPAR; the fraction of photosynthetically active radiation absorbed by the active vegetation; H; sensible heat fl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Keywords: ADME; absorption distribution metabolism and excretion; AEDs; antiepileptic drugs; AUC; area under the plasma drug concentration-time curve; BBB; blood-brain barrier; CBZ; carbamazepine; CBZ-E; carbamazepine-10,11-epoxide; Cmax; maximum peak concentra

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه