XIAP Interacts with and Regulates the Activity of FAF1
Keywords: apoptosis; XIAP; FAF1; Fas/CD95 pathway; NF-κB pathway;
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ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin
Keywords: ALKBH8; Bladder cancer; Anti-apoptotic factor; Tumor progression; ALKBH; AlkB homolog; BBN; N-butyl-N-(4-hydroxybutyl)-nitrosamine; IAP; inhibitor of apoptosis protein; NOX1; NADPH oxidase 1; ROS; reactive oxygen species; siRNA; small interfering RNA; TG;
T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production
Keywords: IAP antagonist; T-3256336; TNFα; cIAP; IAP; Inhibitors of apoptosis protein; XIAP; X-linked inhibitor of apoptosis protein; cIAP; cellular inhibitors of apoptosis protein; SMAC; second mitochondrial-derived activator of caspases; NF-κB; nuclear factor-k
Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3
Keywords: cIAP; cellular inhibitor of apoptosis protein; DFX; Desferrioxamine; DMOG; dimethyl oxalylglycine; EGLN; Caenorhabditis elegans gene egl-9; HA; hemagglutinin; HEK293 cells; human embryonic kidney 293 cells; IB; immunoblotting; IP; immunoprecipitation; HIF
BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells
Keywords: EZH2; BCR/ABL; XIAP; miR-219
TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours
Keywords: TRIM; tripartite motif; RING; really interesting new gene; NHL, NCL-1; HT2A and lin-41; LGMD; limb-girdle muscular dystrophy; XIAP; X-linked inhibitor of apoptosis; PIAS; protein inhibitor of activated STAT; NDRG2; N-myc downstream regulated gene 2; Abi2;
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
Keywords: Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho
Evaluation of the cytotoxic, apoptosis inducing activity and molecular docking of spiroquinazolinone benzamide derivatives in MCF-7 breast cancer cells
Keywords: Apoptosis; Survivin; Spiroquinazolinone benzamide; MCF-7 cells; 4t-CHQB; N-(4-tert-butyl-4'-oxo-1â²H-spiro[cyclohexane-1,2'-quinazoline]-3â²(4â²H)-yl)benzamide; Caspases; cysteine-aspartic proteases; IAPs; inhibitor of apoptosis proteins; XIAP; X-Linke
Ultrasound-responsive microbubbles for sonography-guided siRNA delivery
Keywords: Microbubbles; RNA interfering; XIAP; siRNA-loaded microbubble; Contrast-enhanced ultrasound (CEUS);
Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study
Keywords: Colorectal cancer; Bid; Bim; Survivin; xIAP; ROS; Isoledene; Mesua ferrea;
Microduplication of chromosome Xq25 encompassing STAG2 gene in a boy with intellectual disability
Keywords: Intellectual disability; Microduplication; XIAP; STAG2; Genome-wide array analysisCASP3, cell-death proteases, caspase-3; CASP7, caspase-7; CNVs, copy number variations; DAPI, 40,6-diamidino-2-phenylindole; DD, developmental delay; FISH, fluorescence in s
Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia
Keywords: microRNA; miR-181a; Stroke; BCL2; Inflammation; XIAP; Rotarod; Focal ischemia
AML sensitivity to YM155 is modulated through AKT and Mcl-1
Keywords: YM155; Akt; XIAP; Bcl-2; Mcl-1; AML;
Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2α phosphorylation in prostate cancer
Keywords: CHO; Chinese hamster ovary; CHX; cycloheximide; DIG; digoxigenin; FACS; fluorescence-activated cell sorting; GCN2; general control non-derepressible-2; HRI; heme regulated inhibitor of translation; IRES; internal ribosome entry sites; ITAFs; IRES trans-ac
Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells
Keywords: Phosphorylated HSP27; Nonphosphorylated HSP27; Gemcitabine; Pancreatic cancer; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; DR5; death receptor 5; EGFP; enhanced green fluorescence protein; XIAP; X-linked inhibitor of apoptosis; MAPK; m
Induction of TNF-α signaling cascade in neonatal rat brain during propofol anesthesia
Keywords: Propofol; Brain development; TNF-α signalling; NF-κB; c-Fos; XIAP
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer
Keywords: Apoptosis; SUM149; Antioxidant; XIAP; NFκB; ALDH;
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Keywords: Anticancer drugs; Prognosis; Sp1; Sp3; Transcription factors; Targeted therapy; AMPKα; AMP-activated protein kinase alpha catalytic subunit; Bcl-2; B cell/lymphoma 2; Bcl-w; member of the Bcl-2 family; Bid; BH3 interacting domain death agonist; CDK; cycl
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance
Keywords: ChIP; chromatin immunoprecipitation; FHRE; forkhead responsive elements; FISH; fluorescence in situ hybridization; FOX; forkhead box; HR; hormone receptor; IAP; inhibitor of apoptosis protein; IHC; immunohistochemistry; MTT; 3-(4,5-dimethylthiazlol-2-yl)-
MicroRNAs as regulatory elements in triple negative breast cancer
Keywords: HER2; human epidermal growth factor receptor 2; RISC; RNA-induced silencing complex; NF-κB; nuclear factor κB; Rb; retinoblastoma; XIAP; X-linked inhibitor of apoptosis; VHL; von Hippel-Lindau; PKCα; protein kinase Cα; TNBC; triple negative breast c
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Keywords: Inhibitors of Apoptosis Proteins; XIAP; cIAP; Smac; Structure-based drug design; Ring-closing metathesis;
microRNA-7: A tumor suppressor miRNA with therapeutic potential
Keywords: ACK1; activated CDC42 kinase 1; Akt; V-Akt murine thymoma viral oncogene homolog; BCL-2; B-cell CLL/lymphoma 2; CCNE1; cyclin E1; ciRS-7; circular RNA sponge 7; c-Myc; V-Myc avian myelocytomatosis viral oncogene homolog; EGFR; epidermal growth factor rece
Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
Keywords: Eukaryotic elongation factor-2; Diphthamide; Lipid peroxidation; XIAP; FGF-2; Internal ribosomal entry site; Free radicals;
Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death
Keywords: AIF; apoptosis-inducing factor; asc; ascorbate; BuOE2; MnTnBuOE-2-PyP5+ (BMX-001), Mn(III) meso-tetrakis-(N-n-butoxyethylpyridinium-2-yl) porphyrin; E2; MnTE-2-PyP5+ (AEOL10113, BMX-010), Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin; GSH; glut
Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis
Keywords: HLH; XLP1; SAP expression; 2B4 function; NK cells; FHL; Familial hemophagocytic lymphohistiocytosis; HLH; Hemophagocytic lymphohistiocytosis; MRFI; Mean relative fluorescence intensity; NK; Natural killer; PID; Primary immune deficiency; R-ADCC; Reverse a
β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
Keywords: βM; β-mangostin; MMP; mitochondrial membrane potential; NF-kB; nuclear factor-kappa B; TNF-α; tumour necrosis factor alpha; ROS; reactive oxygen species; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; HCS; high content screening; PARP; poly ADP ribo
Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers
Keywords: Inflammatory bowel disease; Crohn disease; X-linked inhibitor of apoptosis immunodeficiency; NOD receptors; monocytes; HLH; Hemophagocytic lymphohistiocytosis; HSCT; Allogeneic hematopoietic stem cell transplantation; IBD; Inflammatory bowel disease; MCP-
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP
Keywords: Apoptosis; XIAP; Monovalent Smac mimetics; Probe compounds;
XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells
Keywords: XIAP; Proteasome; Gene expression; AML; Caspase; IκBα;
Tuning NF-κB activity: A touch of COMMD proteins
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; COMMD; copper metabolism gene MURR1 domain-containing protein; CRL; Cullin RING ligase; CRM1; chromosome region maintenance 1/exportin 1; CYLD; cylindromatosis; DUB; deubiquitinating enzyme; ENaC;
Hemophagocytic Lymphohistiocytosis: Advances in Pathophysiology, Diagnosis, and Treatment
Keywords: ATG; Antithymocyte globulin; CTL; Cytotoxic T lymphocyte; EBV; Epstein-Barr virus; FHLH; Familial hemophagocytic lymphohistiocytosis; HCT; Hematopoietic stem cell transplantation; HLH; Hemophagocytic lymphohistiocytosis; IFN; Interferon; IL; Interleukin;
Relevance of signaling molecules for apoptosis induction on influenza A virus replication
Keywords: Akt; v-akt murine thymoma viral oncogene homolog 1; Apaf-1; apoptotic protease activating factor 1; Bax; Bcl-2-associated x protein; Bcl-2; B-cell lymphoma 2; BH; Bcl-2 homology; Caspases; cysteine-aspartic acid protease; DAP3; death-associated protein
Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration
Keywords: Colorectal cancer; Ionizing radiation; Invasion; Migration; Survivin; Three-dimensional cell culture; XIAP;
The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators
Keywords: ERα; estrogen receptor alpha; CBP; CREB-binding protein; SRC-1; steroid receptor coactivator 1; SRA; steroid receptor RNA activator; RNA Pol II; RNA polymerase II; P/CAF; CBP/p300 associated factor; TFIIA; transcription factor IIA; AR; androgen receptor;
Brief CommunicationX-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Keywords: XIAP; BIRC4; Hemophagocytic lymphohistiocytosis; Inflammatory bowel disease; Hematopoietic stem cell transplantation;
XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells
Keywords: CML; chronic myeloid leukemia; Pgp; P-glycoprotein; MDR; multidrug resistance; IAPs; inhibitor of apoptosis proteins; RFI; ratio of mean of fluorescence intensity; MFI; mean of fluorescence intensity; Rho-123; rhodamine-123; CSA; cyclosporin A; VRP; verap
A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma
Keywords: Timosaponin AIII; Apoptosis; Autophagy; XIAP; Lysosomal proteolysis;
The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis
Keywords: TRAIL; TNF-related apoptosis-inducing ligand; TNF; tumor necrosis factor; RA; rheumatoid arthritis; RANKL; Receptor Activator for Nuclear Factor κ B Ligand; FLSs; fibroblast like synoviocytes; FLIP; FLICE-like inhibitory protein; McL-1; induced myeloid l
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells
Keywords: HATU; O-(7-azabenzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium hexafluorophosphate; DIPEA; N-ethyldiisopropylamine; Ac; acetyl; CDCl3; deuteratedchloroform; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; DMT-MM; 4-(4,6-dimethoxy-1,3,5-triazin-2-
Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression
Keywords: WA, withaferin A; IAP, inhibitor of apoptosis; XIAP, X-linked inhibitor of apoptosis; DMSO, dimethyl sulfoxide; DAPI, 4′,6-diamidino-2-phenylindole; PARP, poly-(ADP-ribose)-polymeraseWithaferin A; Breast cancer; Apoptosis; XIAP; Survivin
Antagonists of IAP proteins as cancer therapeutics
Keywords: IAP; Antagonist; Apoptosis; XIAP; c-IAP; SMAC; TNF
Doxorubicin induces cell death in breast cancer cells regardless of Survivin and XIAP expression levels
Keywords: XIAP; Survivin; Doxorubicin; Chemoresistance; Breast cancer
Targeting apoptosis pathways in lung cancer
Keywords: Lung cancer; Apoptosis; TRAIL; XIAP; Survivin; BCL-2; TherapyALK, anaplastic lymphoma kinase; BAX, B-cell lymphoma associated X protein; BAK, B-cell lymphoma antagonist/killer 1; BCL-2, B-cell lymphoma 2; BCL-XL, B-cell lymphoma-extra large; BH3, B-cell l
Pulling the plug on a cancer cell by eliminating XIAP with AEG35156
Keywords: XIAP; Antisense; AEG35156; Cancer therapy; IAP; Apoptosis; Clinical trials
Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization
Keywords: qHTS; SUM149; SUM190; Lapatinib; XIAP; Redox adaptation
Anti-HER3 Domain 1 and 3 Antibodies Reduce Tumor Growth by Hindering HER2/HER3 Dimerization and AKT-Induced MDM2, XIAP, and FoxO1 Phosphorylation
Keywords: Ab; antibody; NRG; neuregulin; PBS; phosphate-buffered saline; TR-FRET; time-resolved fluorescence resonance energy transfer; XIAP; X-linked inhibitor of apoptosis; FoxO1; forkhead box O1; MDM2; murine double minute 2; GSK3; glycogen synthase kinase 3;