کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10010535 1587671 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium
چکیده انگلیسی
Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of MRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki-67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of MRH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 53, Issue 6, December 2005, Pages 1075-1079
نویسندگان
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