کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10144112 | 1646296 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Etidronate-zinc Complex Ameliorated Cognitive and Synaptic Plasticity Impairments in 2-Vessel Occlusion Model Rats by Reducing Neuroinflammation
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کلمات کلیدی
IL-1βIBA1fEPSP2-VOBPSDepotentiationNR2BNR2ASYPCCHDEPNF-κBTBSCOX-2EtidronateLFSiNOSinitial training - آموزش ابتداییETI - اتیNeuroinflammation - التهاب عصبیtwo-vessel occlusion - انسداد دو طرفهInterleukin-1β - اینترلوکین-1βBisphosphonates - بیس فسفوناتlow-frequency stimulation - تحریک با فرکانس پایینtheta burst stimulation - تحریک تئاتاnovel object recognition test - تست تشخیص جدید رمانMorris water maze test - تست ماز آب موریسlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP SET - تنظیمtumor necrosis factor-α - تومور نکروز عامل αRET - حقinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییSynaptophysin - سیناپتوفیزینCyclooxygenase-2 - سیکلوکوکسیژناز2TNF-α - فاکتور نکروز توموری آلفاnuclear factor-κB - فاکتور هسته ای κBionized calcium-binding adaptor molecule 1 - ملکول آداپتور اتصال دهنده کلسیم یونیزه 1Chronic cerebral hypoperfusion - هیپرفرفی عروق کرونرField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیرpostsynaptic density protein 95 - پروتئین چگالی Postynaptic 95Synaptic plasticity - پلاستیسیته سیناپسیLearning and memory - یادگیری و حافظه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
As one of the bisphosphonate derivatives, etidronate has proved to be beneficial to spatial learning and memory deficits caused by two-vessel occlusion (2-VO). In this study, the novel drug etidronate-zinc complex (Eti-Zn) was used to detect its role in synaptic plasticity and learning and memory functions in a rat model of 2-VO. Chronic cerebral hypoperfusion was induced by permanent occlusion of the common carotid artery bilaterally in adult Sprague-Dawley rats. Eti-Zn (20â¯mg/kg/day, tail vein injection) was administered for 7â¯days after a two-week operation. After treatment, a series of tests were carried out. Here, we found that Eti-Zn could reduce spatial learning and memory impairments in 2-VO model rats via the Morris water maze test. We also found that animals treated with Eti-Zn showed preference for the new-object in the novel object recognition test. In addition, the long-term potentiation and depotentiation from the Schaffer collaterals to the CA1 region in the hippocampus were enhanced by Eti-Zn treatment in 2-VO model rats. Furthermore, Eti-Zn significantly up-regulated NMDA receptor (NR) 2A, NR2B, postsynaptic density protein 95 and synaptophysin levels and prevented the destruction of dendritic spines. Moreover, Eti-Zn treatment reduced both the over-activation of microglia and the expressions of neuroinflammatory cytokines (TNF-α, IL-1β and IL-6) in the hippocampus. The increased NF-κB signaling pathway in the hippocampus of 2-VO rats was reversed after Eti-Zn treatment. In summary, these findings suggest that Eti-Zn could ameliorate the synaptic plasticity and cognitive impairments by reducing neuroinflammation in 2-VO model rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 390, 15 October 2018, Pages 206-217
Journal: Neuroscience - Volume 390, 15 October 2018, Pages 206-217
نویسندگان
Lina Feng, Jing Gao, Yuexiang Wang, Yuen-Ki Cheong, Guogang Ren, Zhuo Yang,