کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162326 | 1114326 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets
ترجمه فارسی عنوان
افزایش رقت و فرمولاسیون مینی قرصهای لورونسکامام سریع
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کلمات کلیدی
قابلیت دسترسی زیستی، نرخ انحلال، عضلات فرمول بندی، تحویل داروی خوراکی، جذب دهانی، خواص فیزیکوشیمیایی، ثبات فیزیکی، قرص پراکندگی جامد،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic® F-68 (PLU) and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, differential scanning calorimetry, X-ray diffraction, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid-release LOR mini-tablets were further evaluated for their in vivo pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® (STA) and Emcompress®) for mini-tablet formulation. The formulation with STA provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-month stability study and was selected for further in vivo evaluation. The pharmacokinetic profile indicated the potential of the mini-tablets achieving rapid release and increased absorption of LOR. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2470-2483, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 8, August 2014, Pages 2470-2483
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 8, August 2014, Pages 2470-2483
نویسندگان
Hesham M. Tawfeek, Imran Y. Saleem, Matthew Roberts,