کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162619 | 1114335 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory Effect of Valsartan on the Intestinal Absorption and Renal Excretion of Bestatin in Rats
ترجمه فارسی عنوان
اثر مهاری از وستراتسان بر جذب روده و دفع کلیوی فراستین در موش صحرایی
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کلمات کلیدی
AUC, area under the plasma concentration-time curveTEA, tetraethyl ammoniumACEI, Angiotensin-converting enzyme inhibitor - ACEI، آنژیوتانسین تبدیل آنزیم مهار کنندهLC-MS/MS, liquid chromatography-tandem mass spectrometry - LC-MS / MS، طیف سنجی جرمی کروماتوگرافی-دو طرفهMRP, multidrug resistance-associated protein - MRP، پروتئین مرتبط با مقاومت چند داروییOAT, organic anion transporter - OAT، حمل کننده آنیون آلیOCT, organic cation transporter - OCT، حمل و نقل کاتیونی آلیP-gp, P-glycoprotein - P-gp، P-glycoproteinpharamcokinetics - Pharamcokineticst1/2, half-life - t1 / 2، نیمه عمرDrug interaction - تعاملات داروییIntestinal absorption - جذب رودهPeptide transporters - حمل و نقل پپتیدهorganic anion transporters - حملونقل آنیونی آلیRenal excretion - دفع کلیوی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Peptidomimetic drugs have favorable bioavailability owing to H+/peptide transporter 1 (PEPT1) located in the intestine. Sartans are commonly used and likely coadministered with peptidomimetic drugs in the clinic; however, in vivo interactions between sartans and peptidomimetic drugs have not been systemically understood. Herein, the effect and mechanism of sartans on the intestinal absorption and renal excretion of the dipeptide-like drug bestatin were investigated. Following oral combination with valsartan, the plasma concentration and area under the plasma concentration-time curve of bestatin in rats decreased significantly. Bestatin absorption in rat-everted intestinal sacs was dramatically reduced by valsartan. Sartans exhibited concentration-dependent inhibition on the uptake of bestatin in human PEPT1 (hPEPT1)-HeLa cells. The cumulative urinary excretion and renal clearance of the two drugs in rats decreased after intravenous coadministration. Moreover, decreased uptake of the two drugs was observed in rats' kidney slices and human organic anion transporter (hOAT)1/hOAT3-transfected cells when coadministered. The results suggest that the intestinal absorption and renal excretion of bestatin in rats were inhibited by coadministered valsartan. Interestingly, the half-maximal inhibitory concentration (IC50) values of valsartan for PEPT1 and OAT1/3 were comparable to the theoretically estimated local drug concentration and the clinical unbound concentration, respectively, proposing possible drug-drug interaction in humans via PEPT1 and OAT1/3, which should be paid particular attention when bestatin and valsartan are coadministrated clinically.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 2, February 2014, Pages 719-729
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 2, February 2014, Pages 719-729
نویسندگان
Xiaokui Huo, Qi Liu, Changyuan Wang, Qiang Meng, Huijun Sun, Jinyong Peng, Xiaochi Ma, Pengyuan Sun, Kexin Liu,