کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10216967 1683384 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research Techniques Made Simple: Animal Models of Wound Healing
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Research Techniques Made Simple: Animal Models of Wound Healing
چکیده انگلیسی
Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal models should strive for reproducibility, quantitative interpretation, clinical relevance, and successful translation into clinical use. In this concise review, we discuss animal models used in wound experiments including mouse, rat, rabbit, pig, and zebrafish, with a special emphasis on impaired wound healing models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 10, October 2018, Pages 2095-2105.e1
نویسندگان
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