کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298081 | 539119 | 2015 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of GABA-A receptors during postnatal brain development increases anxiety- and depression-related behaviors in a time- and dose-dependent manner in adult mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LMAS.E.MLCTLCELDBopen arm timeEZMBicucullineTSTFSTCAEEPMTLCCRHPNDCATOAE - CESDMSO - DMSOForced swimming test - آزمون اجباری شناTail suspension test - آزمون تعلیق دمAnxiety - اضطرابDepression - افسردگیelevated plus maze - بالا به همراه پیچ و خمanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceLight–dark box - جعبه نور تاریکOat - جو دو سرstandard error of the mean - خطای استاندارد میانگینDimethyl sulfoxide - دیمتیل سولفواکسیدpostnatal day - روز پس از زایمانearly life - زندگی زودهنگامSAP - شیرهLocomotor activity - فعالیت locomotorelevated zero maze - لجن صفر بالاPVN - مالیات بر ارزش افزودهHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالmuscimol - موسیمول Open field - میدان بازHPA - میلی بار یا هکتوپاسکالparaventricular nucleus - هسته پروژسترویکcorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالopen arm entries - ورودی بازوی بازLOPE - کافیهCORT - کورتCorticosterone - کورتیکوسترونGABA - گاباgamma-amino butyric acid - گاما آمینو اسید بوتیریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Disturbances of the gamma-amino butyric acid-ergic (GABAergic) system during postnatal development can have long-lasting consequences for later life behavior, like the individual's response to stress. However, it is unclear which postnatal windows of sensitivity to GABA-ergic modulations are associated with what later-life behavioral outcomes. Therefore, we sought to determine whether neonatal activation of the GABA-A receptor during two postnatal periods, an early window (postnatal day 3-5) and a late window (postnatal day 14-16), can affect anxiety- and depression-related behaviors in male mice in later life. To this end, mice were treated with either saline or muscimol (50, 100, 200, 300 and 500 μg/kg) during the early and late postnatal periods. An additional group of mice was treated with the GABA-A receptor antagonist bicuculline+muscimol. When grown to adulthood male mice were exposed to behavioral tests to measure anxiety- and depression-related behaviors. Baseline and stress-induced corticosterone (CORT) levels were also measured. The results indicate that early postnatal and to a lesser extent later postnatal exposure to the GABA-A receptor agonist muscimol increased anxiety-like behavior and stress-induced CORT levels in adults. Moreover, the early postnatal treatment with muscimol increased depression-like behavior with increasing baseline CORT levels. The anxiogenic and depression-like later-life consequences could be antagonized by bicuculline. Our findings suggest that GABA-A receptor signaling during early-life can influence anxiety- and depression-related behaviors in a time- and dose-dependent manner in later life. Our findings help to increase insight in the developmental mechanisms contributing to stress-related disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 8, August 2015, Pages 1260-1274
Journal: European Neuropsychopharmacology - Volume 25, Issue 8, August 2015, Pages 1260-1274
نویسندگان
Ali-Akbar Salari, Amir Bakhtiari, Judith R. Homberg,