کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10434925 | 910788 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modeling the fluid-dynamics and oxygen consumption in a porous scaffold stimulated by cyclic squeeze pressure
ترجمه فارسی عنوان
مدل سازی دینامیک سیال و مصرف اکسیژن در یک داربست متخلخل تحریک شده توسط فشار سیلیکونی فشار
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CDFFSImicroCTGTABDFALE - اماBioreactor - بیورآکتور یا رآکتور زیستیFluid–structure interaction - تعامل ساختار مایعFluid–structure interactions - تعاملات ساختار مایعMicro-computed tomography - توموگرافی کامپیوتری میکروLaminar flow - جریان آرامComputational fluid-dynamics - دینامیک سیالات محاسباتیBackward differentiation formula - فرمول تمایز عقب ماندهArbitrary Lagrangian–Eulerian - لاگرانژی و اویلر خودسرانهCFD model - مدل CFDOxygen consumption - مصرف اکسیژنCardiac tissue engineering - مهندسی بافت قلبیGlutaraldehyde - گلوتارالدئید
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
The architecture and dynamic physical environment of tissues can be recreated in-vitro by combining 3D porous scaffolds and bioreactors able to apply controlled mechanical stimuli on cells. In such systems, the entity of the stimuli and the distribution of nutrients within the engineered construct depend on the micro-structure of the scaffolds. In this work, we present a new approach for optimizing computational fluid-dynamics (CFD) models for the investigation of fluid-induced forces generated by cyclic squeeze pressure within a porous construct, coupled with oxygen consumption of cardiomyocytes. A 2D axial symmetric macro-scaled model of a squeeze pressure bioreactor chamber was used as starting point for generating time dependent pressure profiles. Subsequently the fluid movement generated by the pressure fields was coupled with a complete 3D micro-scaled model of a porous protein cryogel. Oxygen transport and consumption inside the scaffold was evaluated considering a homogeneous distribution of cardiomyocytes throughout the structure, as confirmed by preliminary cell culture experiments. The results show that a 3D description of the system, coupling a porous geometry and time dependent pressure driven flow with fluid-structure-interaction provides an accurate and meaningful description of the microenvironment in terms of shear stress and oxygen distribution than simple stationary 2D models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Engineering & Physics - Volume 38, Issue 8, August 2016, Pages 725-732
Journal: Medical Engineering & Physics - Volume 38, Issue 8, August 2016, Pages 725-732
نویسندگان
Marco Ferroni, Serena Giusti, Diana Nascimento, Ana Silva, Federica Boschetti, Arti Ahluwalia,