Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

Synthesis, in vitro cellular uptake and in vivo biodistribution of hyaluronan-based nanoparticles in non-small cell lung cancer. Specificity of nanoparticles with different size to hyaluronan cell surface receptors was demonstrated in vitro. Nanoparticles' biodistribution was assessed after intravenous or intrapulmonary administration using two orthotopic lung tumor models. Data showed that nebulized nanoparticles failed to target orthotopic lung tumor. In contrast, an accumulation in lung tumor of the smaller nanoparticles was observed after intravenous injection.124