Stability of early-stage amyloid-β(1-42) aggregation species

► We observed fibrillar structural elements at very early stages of Aβ incubation. ► We compared the formation of these elements between Aβ(1-42) and Aβ(1-40). ► We identified stability differences between Aβ(1-42) and Aβ(1-40) oligomers. ► We demonstrated the development of SDS resistance in early Aβ(1-42) oligomers.