کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10547839 | 965301 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimization of isocratic supercritical fluid chromatography for enantiomer separation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper presents multi-objective optimization analysis and experimental implementation of a single column isocratic supercritical fluid chromatography process for the enantioseparation of flurbiprofen. The single column process is simulated using a detailed model with equilibrium description by a competitive Langmuir isotherm. The optimization problem has been formulated with the objectives of maximizing productivity and minimizing solvent consumption under different product purity and recovery constraints. The solubility of the solute in the mobile phase is explicitly accounted in the problem formulation. The results showed a maximum productivity of 5Â kg racemate/kg stationary phase/day with a corresponding organic solvent consumption of 80Â LÂ kgâ1 racemate for a required purity and recovery of 95%. The optimal operating conditions have been experimentally implemented in an analytical scale laboratory set-up which support the optimization results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 1, 7 January 2011, Pages 162-170
Journal: Journal of Chromatography A - Volume 1218, Issue 1, 7 January 2011, Pages 162-170
نویسندگان
Chen Wenda, Reza Haghpanah, Arvind Rajendran, Mohammad Amanullah,