Extraction optimization approach to improve accessibility of functional fraction based on combination of total polyphenol, chromatographic profiling and antioxidant activity evaluation: Pyracantha fortuneana fruit as an example

► Antioxidant activity, chromatographic profiling from edible wild Pyracantha fortuneana fruit. ► Multilateral assessment for functional fraction with maximal recovery and bioaccessibility. ► Technical combination of RSM, HPLC-DAD-MS profiling and spectrophotometric determination. ► Solid extraction and liquid-liquid extraction. ► Polyphenolic chromatographic profiling and LC-MS identification.