کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10588825 | 981505 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors
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کلمات کلیدی
MMPHPMZBGBSA - BSAHydroxamic acid - اسید هیدروکسامBenzenesulfonamide - بنزن سولفونامیدSulfonamides - سولفونامیدmatrix metalloproteinase - ماتریکس متالوپروتئینازMMP inhibitors - مهار کننده های MMPCarbonic anhydrase inhibitors - مهار کننده های کربن انیدراتاCarbonic anhydrase - کربونیک آنهیدرازZinc-binding group - گروه اتصال دهنده روی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors](/preview/png/10588825.png)
چکیده انگلیسی
A set of benzenesulfonamide (BSA) derivatives bearing a hydroxypyrimidinone (HPM) moiety were synthesized and investigated for their inhibitory activity against several carbonic anhydrase (CA, EC 4.2.1.1) isozymes. They all revealed to be very potent inhibitors (nanomolar order) of the cytosolic CA I and II isozymes, but especially of the transmembrane, tumor-associated CA IX isozyme, a beneficial feature for a potential antitumor effect of these compounds. Further structure optimization aimed at improving the specificity of CA inhibition and enhancing their matrix metalloproteinase (MMP) inhibitory activity may also lead to new compounds with an attractive dual mechanism of action as antitumor agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3623-3627
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3623-3627
نویسندگان
M. Alexandra Esteves, Osvaldo Ortet, Anabela Capelo, Claudiu T. Supuran, Sérgio M. Marques, M. Amélia Santos,