Selective endothelial cells adhesion to Arg-Glu-Asp-Val peptide functionalized polysaccharide multilayer

► The (heparin/chitosan) multilayer was fabricated via layer-by-layer deposition. ► Native (heparin/chitosan) multilayer is cell-resistant. ► Chemistry-crosslinking converts the multilayer to a cells adhesive surface. ► Arg-Glu-Asp-Val peptide modified multilayer promotes endothelial cells adhesion.