Metformin protects against doxorubicin-induced cardiotoxicity: Involvement of the adiponectin cardiac system

► Doxorubicin is an antitumoral agent with high cardiotoxicity. ► Metformin is an antidiabetic drug which exerts cardioprotective effects. ► The metformin pretreatment protects cardiomyocytes from doxorubicin-induced damage. ► The cardiac adiponectin system plays an important role in this protective action.