Oxidative stress-induced proteome alterations target different cellular pathways in human myoblasts

► Proteomics of the oxidative stress response of human myoblasts have been performed. ► Differentially expressed proteins as well as oxidized proteins have been identified. ► Skeletal and muscular disorders were the main cellular networks altered. ► However, data mining revealed distinct proteins at the central nodes. ► This study underscores the importance of looking at different aspects of the proteome.