کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739789 | 1046889 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation
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کلمات کلیدی
HCTTNLTNFTotal radical-trapping antioxidant parameterMDANTBIPMNTIBCTRAPNACGSHCPBGSSG, oxidized glutathione - GSSG، گلوتاتیون اکسید شدهN-acetylcysteine - N-استیل سیستئینIron - آهنnon-transferrin-bound iron - آهن غیر انتقال سرمDehydroascorbic acid - اسید DehydroascorbicProtein oxidation - اکسیداسیون پروتئینinterleukin - اینترلوکینcardiopulmonary bypass - بایپس قلب و ریهDHA - دوکوساهگزائنوئیک اسیدFree radicals - رادیکال آزادPolymorphonuclear cells - سلولهای پلیمورفونیکsulfhydryl - سولفیدریلtotal iron binding capacity - ظرفیت اتصال کلی آهنtumor necrosis factor - فاکتور نکروز تومورmalondialdehyde - مالون دی آلدهیدhematocrit - هماتوکریتSystemic inflammatory response - پاسخ سیستماتیک التهابیLipid peroxidation - پراکسیداسیون لیپیدC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی reduced glutathione - کاهش گلوتاتیونhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراChildren - کودکانextracorporeal circulation - گردش خون اضافی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oxidative stress seems to contribute to cardiopulmonary bypass (CPB)-related postoperative complications. Pediatric patients are particularly prone to these complications. With this in mind, we measured oxidative stress markers in blood plasma of 20 children undergoing elective heart surgery before, during, and up to 48 h after cessation of CPB, along with inflammatory parameters and full analysis of iron status. Ascorbate levels were decreased by â¼50% (P < 0.001) at the time of aorta cross-clamp removal (or pump switch-off in 4 patients with partial CPB), and associated with corresponding increases in dehydroascorbate (P < 0.001, r = â0.80) and malondialdehyde (P < 0.01, r = â0.59). In contrast to the immediate oxidative response, peak levels of IL-6 and IL-8 were not observed until 3-12 h after CPB cessation. The early loss of ascorbate correlated with duration of CPB (P < 0.002, r = 0.72), plasma hemoglobin after cross-clamp removal (P < 0.001, r = 0.70), and IL-6 and IL-8 levels at 24 and 48 h after CPB (P < 0.01), but not with postoperative lactate levels, strongly suggesting that hemolysis, and not inflammation or ischemia, was the main cause of early oxidative stress. The correlation of ventilation time with early changes in ascorbate (P < 0.02, r = 0.55), plasma hemoglobin (P < 0.01, r = 0.60), and malondialdehyde (P < 0.02, r = 0.54) suggests that hemolysis-induced oxidative stress may be an underlying cause of CPB-associated pulmonary dysfunction. Optimization of surgical procedures or therapeutic intervention that minimize hemolysis (e.g., off-pump surgery) or the resultant oxidative stress (e.g., antioxidant treatment) should be considered as possible strategies to lower the rate of postoperative complications in pediatric CPB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 38, Issue 10, 15 May 2005, Pages 1323-1332
Journal: Free Radical Biology and Medicine - Volume 38, Issue 10, 15 May 2005, Pages 1323-1332
نویسندگان
Stephan Christen, Barbara Finckh, Jens Lykkesfeldt, Peter Gessler, Manuela Frese-Schaper, Peter Nielsen, Edith R. Schmid, Bernhard Schmitt,