The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells

► UBP43-depletedhematopoietic cells are hypersensitive to IFN-α/β-induced apoptosis. ► Extrinsic pathway is not critical for theapoptosis in UBP43-depleted hematopoietic cells. ► Intrinsic pathway is a major contributor to the apoptosis in Ubp43-depletedhematopoietic cells. ► ROS is a mediator of IFN-α/β-induced apoptosis in UBP43-knockdown THP-1 cells.