Kinemage of action - Proposed reaction mechanism of glutamate-1-semialdehyde aminomutase at an atomic level

► Inhibitors of tetrapyrrole cofactor biosynthesis may be useful antibiotics. ► Mechanism of critical enzyme, glutamate-1-semialdehyde aminomutase, is presented. ► Unique vitamin B6-dependant enzyme traps intermediate in active site. ► Molecular dynamics show that a re-orientation of the substrate is required.