Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects

► Human islets are enriched in miR-375, miR-127-3p and miR-184. ► Expression of miR-375, miR-122, miR-127-3p and miR-184 is positively correlated to insulin biosynthesis. ► Levels of miR-127-3p and miR-184 are negatively correlated to glucose-stimulated insulin secretion. ► These correlations are diminished in islets of glucose-intolerant donors.