کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768121 1050804 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural biology of mammalian lipoxygenases: Enzymatic consequences of targeted alterations of the protein structure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Structural biology of mammalian lipoxygenases: Enzymatic consequences of targeted alterations of the protein structure
چکیده انگلیسی
Lipoxygenases form a heterogeneous family of lipid peroxidizing enzymes, which have been implicated in the pathogenesis of diseases with major health political relevance (bronchial asthma, atherosclerosis, cancer, and osteoporosis). The crystal structures of one mammalian lipoxygenase and of two plant isoenzymes have been solved and the structural bases of important enzyme properties (reaction specificity, membrane binding, and suicidal inactivation) have been investigated in the past. This review will briefly summarize our current understanding on the structural biology of the most important mammalian lipoxygenase isoforms and will also address selected mechanistic features of the lipoxygenase reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 338, Issue 1, 9 December 2005, Pages 93-101
نویسندگان
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