Localization and interaction of genistein with model membranes formed with dipalmitoylphosphatidylcholine (DPPC)

► Genistein interacts with DPPC liposomes and changes their dynamic properties. ► Genistein shows the highest propensity to polar head group zone and below it. ► Hydroxyl groups of genistein are involved in hydrogen link formation. ► C-O-P-O-C segment of the lipid takes part in hydrogen bonding creation. ► Genistein changes the organization of natural membranes.