کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10799149 | 1054236 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptional regulation mechanism mediated by miRNA-DNAâ¢DNA triplex structure stabilized by Argonaute
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کلمات کلیدی
HmglncRNAds-RNAssRNATFMSpiRNAParnaTFOpRNAhnRNPdhfr - Dhfrdouble-stranded DNA - DNA رشته ایds-DNA - Ds-DNAlong non-coding RNA - RNA بدون رمزگذاری طولانیRNA interference - RNA تداخل کنندهSmall interfering RNA - RNA تداخل کوچکsingle-stranded RNA - RNA تک رشته ایdouble-stranded RNA - RNA دو رشته ایRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهsiRNA - siRNATGs - TG هاArgonaute - آرگونوتTriplex-forming oligonucleotide - الیگونوکلئوتید تشکیل دهنده سه گانهchromatin immunoprecipitation - ایمن سازی کروماتینTranscriptional regulation - تنظیم ترانزیتیtranscriptional gene silencing - خاموش کردن ژن رونویسیRISC - خطرdihydrofolate reductase - دی هیدروفلات ردوکتازTranscriptional factor - عامل رونویسیRNA-Induced Silencing Complex - مجتمع خاموش کننده RNA inducedMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAAGO - پیشCHiP - چیپhigh mobility group - گروه تحرک بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Transcription regulation depends on interactions between repressor or activator proteins with promoter sequences, while post-transcriptional regulation typically relies on microRNA (miRNA) interaction with sequences in 5â² and 3â²-Untranslated regions (UTRs) of messenger RNA (mRNA). However, several pieces of evidence suggest that miRNA:Argonaute (AGO) complexes may also suppress transcription through RNA interference (RNAi) components and epigenetic mechanisms. However, recent observations suggest that miRNA-induced transcriptional silencing could be exerted by an unknown mechanism independent of chromatin modifiers. The RNA-DNA
- DNA triplex structure has emerged as an important RNA tertiary motif in which successive non-canonical base pairs form between a DNA-DNA duplex and a third strand. Frequently, promoters have Purine (PU)-rich tracts, and some Triplex-forming oligonucleotides (TFOs) targeting these regulatory regions have been shown to inhibit transcription selectively. Here, we summarize observations suggesting that miRNAs exert regulation over promoter regions through miRNA-DNA
- DNA triplex structure formation stabilized by AGO proteins which represents a plausible model of RNA-mediated Transcriptional gene silencing (TGS).
- DNA triplex structure has emerged as an important RNA tertiary motif in which successive non-canonical base pairs form between a DNA-DNA duplex and a third strand. Frequently, promoters have Purine (PU)-rich tracts, and some Triplex-forming oligonucleotides (TFOs) targeting these regulatory regions have been shown to inhibit transcription selectively. Here, we summarize observations suggesting that miRNAs exert regulation over promoter regions through miRNA-DNA
- DNA triplex structure formation stabilized by AGO proteins which represents a plausible model of RNA-mediated Transcriptional gene silencing (TGS).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1839, Issue 11, November 2014, Pages 1079-1083
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1839, Issue 11, November 2014, Pages 1079-1083
نویسندگان
Julia D. Toscano-Garibay, Guillermo Aquino-Jarquin,