کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10804403 1057265 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse
چکیده انگلیسی
Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 87, Issue 1, January 2005, Pages 73-79
نویسندگان
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