کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10816551 | 1058578 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils
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کلمات کلیدی
PBSCytochalasin BPIP2LPAPLCEtOHPLD18:1 - 18: 1BSA - BSAbovine serum albumin - آلبومین سرم گاوEthanol - اتانولOleic acid - اسید اولئیکphosphatidic acid - اسید فسفاتیدیکlysophosphatidic acid - اسید لیسفسفیدیدphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanol - فسفاتیدیلنتانولphosphatidylinositol 4,5-bisphosphate - فسفاتیدیلینوزیتول 4،5-بیسفسفاتphospholipase C - فسفولیپاز CPhospholipase D - فسفولیپاز DDegranulation - قرمزی چشمPET - پت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils](/preview/png/10816551.png)
چکیده انگلیسی
1-Oleoyl-sn-glycero-3-phosphate, a lysophosphatidic acid (LPA), in serum is a biologically active lipid and has multiple functions depending on the cell types. Several studies have shown that LPA stimulates phospholipase D (PLD) activity in fibroblasts and prostate cancer cells in culture. PLD plays a central role in regulating neutrophil functions. One of the functions of the lipid product, phosphatidic acid (PA), of PLD action in neutrophils is to promote degranulation. In the present study, we examined the effect of LPA on PLD activity and degranulation by human neutrophils. The results show that exogenous LPA increased PA formation, PLD activity and degranulation by human neutrophils in a time and concentration dependent manner. These findings suggest that LPA released from activated platelets during blood clotting may participate in bacterial killing and wound healing process. On the other hand, augmented LPA production might be involved in inflammation, causing damage of the host tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 17, Issue 1, January 2005, Pages 77-82
Journal: Cellular Signalling - Volume 17, Issue 1, January 2005, Pages 77-82
نویسندگان
Jen-sie Tou, Jacquelyn S. Gill,