ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations

► We see metabolic patterns in CSF of different genetic mutations known to cause ALS. ► Significant differences between ALS patients with different SOD1 gene mutations. ► Significant differences between patients with and without SOD 1 mutations. ► Metabolomics can contribute in deciphering the complex interactions behind ALS.