Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats

► CB1 antagonists are clinically effective antiobesity drugs, but induce severe anxiety. ► We tested if this profile can be improved by concurrent CB1 and mGluR5 antagonisms. ► Rimonabant and MTEP exerted synergistic effect in reducing food-intake in rats. ► Anxiogenic-like effect of rimonabant was abolished by MTEP in the adult rat USV test. ► Impaired fear-conditioning caused by MTEP was not ameliorated by rimonabant treatment.