کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10903894 1086539 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases
چکیده انگلیسی
Kinesin superfamily proteins (KIFs) largely serve as molecular motors on the microtubule system and transport various cellular proteins, macromolecules, and organelles. These transports are fundamental to cellular logistics, and at times, they directly modulate signal transduction by altering the semantics of informational molecules. In this review, we will summarize recent approaches to the regulation of the transport destinations and to the physiological relevance of the role of these proteins in neuroscience, ciliary functions, and metabolic diseases. Understanding these burning questions will be essential in establishing a new paradigm of cellular functions and disease pathogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 334, Issue 1, 15 May 2015, Pages 16-25
نویسندگان
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