Cell to extracellular matrix interactions and their reciprocal nature in cancer

► Cell-ECM interactions govern fundamental cellular processes of cancer development. ► Many alterations in cell to ECM interactions occur during cancer progression. ► ECM alterations during cancer progression include ECM deposition and crosslinking. ► Altered intracellular events in cancer includes integrin and actomyosin regulation. ► Cell-ECM interactions are reciprocal in nature and include feed-forward loops.