Flagellin/TLR5 responses induce mucus hypersecretion by activating EGFR via an epithelial cell signaling cascades

► We show the role of flagellin/TLR5 responses in mucus hypersecretion. ► The study shows the interaction of TLR5 and EGFR in airway inflammatory diseases. ► It shows Duox2 is involved in P. aeruginosa-induced mucus hypersecretion. ► It brings new insights into the molecular pathogenesis of P. aeruginosa infections. ► It leads to therapeutic intervention for P. aeruginosa-induced mucin hypersecretion.