کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10962463 | 1102637 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression
ترجمه فارسی عنوان
اثربخشی پروتکل های مختلف واکسن بیماری مارک برای پیشگیری از بیماری امروزی ناشی از بیماری ویروس مارک
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کلمات کلیدی
CEFILTVMDVILTCKCMarek’s disease - بیماری مارکImmune system - دستگاه ایمنی یا سیستم ایمنیImmunosuppression - سرکوب سیستم ایمنیchicken embryo fibroblasts - فیبروبلاست های جنینی مرغInfectious laryngotracheitis - لارنگوتراشیت عفونیCEO - مدیر عاملplaque forming units - واحدهای تشکیل پلاکVaccine - واکسنMarek’s disease virus - ویروس بیماری مارکInfectious laryngotracheitis virus - ویروس لارنگوتراشیت عفونیpfu - پفوControl - کنترل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Marek's disease virus (MDV) induces tumors and severe immunosuppression in chickens. MDV-induced immunosuppression (MDV-IS) is very complex and difficult to study. In particular, the late MDV-IS (late-MDV-IS) is of great concern since it can occur in the absence of lymphoid organ atrophy or gross tumors. We have recently developed a model to reproduce late-MDV-IS under laboratory conditions. This model measures MDV-IS indirectly by assessing the effect of MDV infection on the efficacy of infectious laryngotracheitis (ILT) vaccination; hence the name late-MDV-IS ILT model. In this study, we have used the late-MDV-IS ILT model to evaluate if MD vaccination can protect against late-MDV-IS. One experiment was conducted to determine whether serotype 1 MD vaccines (CVI988 and Md5ÎMEQ) could induce late-MDV-IS by themselves. Three additional experiments were conducted to evaluate efficacy of different MD vaccines (HVT, HVT+SB-1, CVI988, and Md5ÎMEQ) and different vaccine protocols (day-old vaccination, in ovo vaccination, and double vaccination) against late-MDV-IS. Our results show that none of the currently used vaccine protocols (HVT, HVT+SB-1, or CVI988 administered at day of age, in ovo, or in double vaccination protocols) protected against late-MDV-IS induced by vv+MDV strains 648A and 686. Experimental vaccine Md5ÎMEQ administered subcutaneously at one day of age was the only vaccine protocol that significantly reduced late-MDV-IS induced by vv+MDV strain 686. This study demonstrates that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index = 100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late-MDV-IS even in complete absence of tumors. Our results suggest that MDV-IS might not be related to the development of tumors and novel control methods are needed. Further evaluation of the experimental vaccine Md5ÎMEQ might shed light on protective mechanisms against late-MDV-IS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 35, 29 July 2016, Pages 4180-4187
Journal: Vaccine - Volume 34, Issue 35, 29 July 2016, Pages 4180-4187
نویسندگان
Nik M. Faiz, Aneg L. Cortes, James S. Guy, Jonathan E. Fogle, Isabel M. Gimeno,