Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

- FNIII 11-EDA and CpG synergize in vitro to enhance activation of dendritic cells.
- Immunization with both adjuvants induces a potent antigen-specific Th1 response in vivo.
- Co-adjuvanted OVA mediates regression of E.G7-OVA tumors through CTL response.
- Co-adjuvanted HBsAg induces seroconversion and clearance of circulating virus in HBV-Tg mice.