کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10962971 | 1102662 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulated expression of virulence gene mviN provides protective immunity and colonization control of Salmonella in poultry
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Current live attenuated vaccines for control of Salmonella in poultry persist in the ceca and may persist in the environment. In this paper we report the construction and characterization of the vaccine efficacy of a Salmonella mutant strain with inducible mviN expression and rapid clearance from the host. The mutant was effective in oral immunization of the broiler chicken host against a virulent Salmonella oral challenge strain, having a mean 7Â ÃÂ 106Â CFU/g in the ceca of unvaccinated controls compared to a mean 2Â ÃÂ 103Â CFU/g in the ceca of vaccinated chickens at 4 weeks post-challenge (6 weeks of age). The mutant strain also demonstrated immunogenicity, reduced organ colonization, and rapid clearance in broiler chickens within 3 weeks of inoculation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 41, 5 October 2015, Pages 5365-5370
Journal: Vaccine - Volume 33, Issue 41, 5 October 2015, Pages 5365-5370
نویسندگان
Peter M. Rubinelli, Sang In Lee, Stephanie M. Roto, Si Hong Park, Steven C. Ricke,