کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10964773 | 1102726 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation
ترجمه فارسی عنوان
استفاده همزمان از نانوذرات غیر حامل باعث افزایش پاسخ ایمنی آنتی ژن بدون نیاز به پروتئین است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Nanotechnology promises a revolution in medicine including through new vaccine approaches. The use of nanoparticles in vaccination has, to date, focused on attaching antigen directly to or within nanoparticle structures to enhance antigen uptake by immune cells. Here we question whether antigen incorporation with the nanoparticle is actually necessary to boost vaccine effectiveness. We show that the immunogenicity of a sub-unit protein antigen was significantly boosted by formulation with silica nanoparticles even without specific conjugation of antigen to the nanoparticle. We further show that this effect was observed only for virus-sized nanoparticles (50Â nm) but not for larger (1000Â nm) particles, demonstrating a pronounced effect of nanoparticle size. This non-attachment approach has potential to radically simplify the development and application of nanoparticle-based formulations, leading to safer and simpler nanoparticle applications in vaccine development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 32, Issue 29, 17 June 2014, Pages 3664-3669
Journal: Vaccine - Volume 32, Issue 29, 17 June 2014, Pages 3664-3669
نویسندگان
Nani Wibowo, Yap P. Chuan, Arjun Seth, Yoann Cordoba, Linda H.L. Lua, Anton P.J. Middelberg,