Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia in a challenge study with highly pathogenic PRRSV JX143

► Challenge of pigs with HP-PRRSV resulted in typical clinical signs of PHFD. ► Hyperpyrexia and mortality of challenged pigs completely prevented by vaccination. ► Vaccination with a MLV reduced the impact of clinical disease of challenged pigs.